Pasan Witharana

ORCID: 0000-0001-9891-2486
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About
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Research Areas
  • Cardiac Health and Mental Health
  • Lung Cancer Diagnosis and Treatment
  • Gastric Cancer Management and Outcomes
  • Lung Cancer Treatments and Mutations
  • Radiomics and Machine Learning in Medical Imaging
  • Artificial Intelligence in Healthcare and Education
  • Aortic Disease and Treatment Approaches
  • Intensive Care Unit Cognitive Disorders
  • Esophageal Cancer Research and Treatment
  • Cardiac Arrest and Resuscitation
  • Healthcare Systems and Public Health
  • Hip and Femur Fractures
  • Frailty in Older Adults
  • Myasthenia Gravis and Thymoma
  • Trauma Management and Diagnosis
  • Mechanical Circulatory Support Devices
  • Heart Rate Variability and Autonomic Control
  • Lung Cancer Research Studies
  • Cardiac Valve Diseases and Treatments
  • Meningioma and schwannoma management
  • Stroke Rehabilitation and Recovery
  • Cancer Immunotherapy and Biomarkers
  • Mobile Health and mHealth Applications
  • Cardiac Structural Anomalies and Repair
  • Telemedicine and Telehealth Implementation

Northern General Hospital
2021-2025

Imperial College London
2022-2025

South Tees Hospitals NHS Foundation Trust
2023-2024

James Cook University Hospital
2023

Despite surgical resection, the prognosis for patients with non-small cell lung cancer (NSCLC) remains unsatisfactory. The objective of this study was to investigate impact serum carcinoembryonic antigen (CEA) levels on recurrence in NSCLC before and after resection. In addition, invasive adenocarcinoma (IAC), which constitutes majority cases, we further explored effect pathological subtype recurrence. A total 349 were included study. correlation between clinicopathological factors...

10.21037/tlcr-24-776 article EN Translational Lung Cancer Research 2025-02-01

Introduction Cardiac rehabilitation (CR) delivered by specialists in a healthcare setting is effective improving functional capacity and reducing readmission rates after cardiac surgery. It also associated with reduction mortality recurrent myocardial infarction. This trial assesses the feasibility of home-based CR programme using mobile application (app). Methods The Rehabilitation through Exercise prescription for patients an Artificial intelligence web-based Programme (RECAP) randomised...

10.1136/bmjopen-2023-079404 article EN cc-by-nc BMJ Open 2024-04-01

Introduction Prehabilitation prior to surgery has been shown reduce postoperative complications, length of hospital stay and improve quality life after cancer limb reconstruction surgery. However, there are minimal data on the impact prehabilitation in patients undergoing cardiac surgery, despite fact these generally older have more comorbidities frailty. This trial will assess feasibility a intervention consisting exercise inspiratory muscle training preoperative functional capacity adult...

10.1136/bmjopen-2022-065992 article EN cc-by-nc BMJ Open 2023-01-01

Summary The purpose of this study was to understand the views and experiences patients enrolled staff involved in prehabilitation elective undergoing cardiac surgery trial. This sub‐study informed by normalisation process theory, a framework for evaluating complex interventions, used consecutive sampling recruit assigned both intervention control groups. Patients all delivering trial were invited participate focus groups, which recorded, transcribed verbatim subjected reflexive thematic...

10.1111/anae.16082 article EN cc-by Anaesthesia 2023-07-04

The current standard for the surgical management of lung cancer involves anatomic resection combined with systemic lymph node dissection/sampling. purpose this study was to investigate patterns pathological nodes in invasive non-small cell (NSCLC), explore occurrence metastasis (LNM), and provide recommendations optimal resection/sampling operation.

10.21037/tlcr-24-450 article EN Translational Lung Cancer Research 2024-11-01

Background: The detection of pulmonary nodules significantly impacts the lives and mental health patients. Although 2020 National Comprehensive Cancer Network (NCCN) guidelines recommend scheduled surveillance for ≤8 mm, patients often opt to have their surgically removed. Methods: A cross-sectional questionnaire was administered with small who presented a local grade 3 hospital decided receive surgery versus prescribed monitoring. included four aspects: (I) patient characteristics; (II)...

10.21037/jtd-23-1701 article EN Journal of Thoracic Disease 2023-12-01

Background: Traumatic tracheal rupture is a severe closed chest injury that often causes major respiratory and circulatory disturbances requiring emergency surgery. We have found veno-venous extracorporeal membrane oxygenation (VV-ECMO) employs lung-protective ventilation strategies to facilitate lung rest, aiming minimize the risk of ventilator-induced injury, while ensuring adequate oxygenation. Case Description: presented 3 critically ill patients who with traumatic bronchial between 2019...

10.21037/jtd-23-1783 article EN Journal of Thoracic Disease 2023-12-01

Abstract Background: The detection of pulmonary nodules has a great impact on people's lives and mental health. 2018 NCCN guidelines recommend follow-up treatment for ≤8mm, but many patients with small choose surgery. We wanted to explore why these had surgery what caused their anxiety. Methods: cross-sectionally surveyed who decided undergo in local grade 3 hospital, using questionnaire. Results: 338 responded, only 234 were included the final analysis. 68.81% reported clinically...

10.21203/rs.3.rs-1611698/v1 preprint EN cc-by Research Square (Research Square) 2022-05-19

Intramural Hematoma (IMH) forms part of the acute aortic syndrome, dissection, and penetrating ulcer. It is a life-threatening disease that warrants prompt diagnosis management. Like dissections, it classified using Stanford classification system as type A (proximal to origin left subclavian artery) B (distal artery). Patients with IMH generally managed surgically, uncomplicated medically. The right artery arises typically from brachiocephalic trunk. Aberrant arteries (ARSA) are rare derive...

10.1016/j.radcr.2022.05.004 article EN cc-by-nc-nd Radiology Case Reports 2022-05-29

Abstract Introduction An aortic dissection occurs when there is a tear in the intimal and medial layer of aorta, leading to false lumen within media. Type B dissections (TBAD), according Stanford Classification are where entry located distally from left subclavian artery. Resolution (TBAD) by medical therapy very rare event. Case Presentation 58-year-old gentleman presented with sudden onset central chest pain. A CTPA was organised following high d-dimer. This showed TBAD extending origin...

10.1093/bjs/znab259.245 article EN British journal of surgery 2021-09-01
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