A5101618774- Genetic Mapping and Diversity in Plants and Animals
- Crop Yield and Soil Fertility
- Agricultural Systems and Practices
- Genetics and Plant Breeding
- Aquaculture disease management and microbiota
- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
- RNA and protein synthesis mechanisms
- Chromosomal and Genetic Variations
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- Histone Deacetylase Inhibitors Research
- Energy, Environment, Economic Growth
- RNA modifications and cancer
- Aquaculture Nutrition and Growth
- RNA Interference and Gene Delivery
- Heme Oxygenase-1 and Carbon Monoxide
- Phytoestrogen effects and research
- Child Nutrition and Water Access
- Economic Growth and Development
- Extracellular vesicles in disease
- Bioactive Compounds and Antitumor Agents
- Multisensory perception and integration
Harbin Medical University
2025
Shanghai Ocean University
2022-2024
Ministry of Agriculture and Rural Affairs
2022-2024
Sichuan University
2024
State Key Laboratory of Oral Diseases
2024
Beijing Technology and Business University
2022-2024
First Hospital of China Medical University
2023
Jiangsu Normal University
2023
China Medical University
2022
East China University of Science and Technology
2017-2021
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Identifying genotype-phenotype links and causative genes from quantitative trait loci (QTL) is challenging for complex agronomically important traits. To accelerate maize gene discovery breeding, we present the Complete-diallel design plus Unbalanced Breeding-like Inter-Cross (CUBIC) population, consisting of 1404 individuals created by extensively inter-crossing 24 widely used Chinese founders.
Abstract Digital technology is an important tool to smooth the dual circulation. This paper empirically examines impact of digital on enterprise circulation and its mechanism based data enterprises in ZGC from 2013 2019. It shows that can significantly promote circulation, this conclusion still holds after a series robustness tests. Mechanisms analyzed found promotes by unclogging blockages production, distribution, consumption chain. Further research facilitates NSOEs more than SOEs....
Alternative splicing (AS) enhances transcriptome diversity and plays important roles in regulating plant processes. Although widespread natural variation AS has been observed plants, how is regulated contribute to phenotypic poorly understood. Here, we report a population-level assembly genome-wide association study identify quantitative trait loci (sQTLs) developing maize (Zea mays) kernels from 368 inbred lines. We detected 19,554 unique sQTLs for 6570 genes. Most showed small isoform...
Asthma is a chronic inflammatory disease featured by inflammation and remodeling of airway. Adipose-derived mesenchymal stem cell (ADSCs)-derived exosomal miRNAs have been suggested as promising therapeutic manners for diseases.ADSCs airway smooth muscle cells (ASMCs) were isolated from SD rats. Flow cytometry was conducted to detect the surface biomarkers cells. Exosomes extracted sequentially centrifuge method identified Western blotting nanoparticle tracking analysis (NTA). Uptake...
Arsenic trioxide (ATO), the active ingredient in Chinese arsenic, effectively inhibits hepatocellular carcinoma (HCC) cell growth, but its clinical application is limited by lack of a targeted delivery system. Phosphatidylinositol proteoglycan 3 (GPC3) specifically expressed HCC, and CPP44 cell-penetrating peptide that targets HCC cells. Here, we developed liposome incorporating ATO with dual surface modifications anti-GPC3 antibody CPP44. The system was firstly enriched localized at liver...
CRISPR-Local is a high-throughput local tool for designing single-guide RNAs (sgRNAs) in plants and other organisms that factors genetic variation optimized to generate genome-wide sgRNAs. outperforms sgRNA design tools the following respects: (i) sgRNAs suitable non-reference varieties; (ii) screening are capable of simultaneously targeting multiple genes; (iii) saving computational resources by avoiding repeated calculations from submissions (iv) running offline, with both command-line...
The TAT–DCF1 protein possesses great potential for the development of glioblastoma therapy through interaction with TAF6-related pathways.
Abstract Background and Objectives Histone deacetylase (HDAC) families regulate various physical processes the development of several diseases. The role HDACs in asthma progression worths further investigation. This study aims to evaluate effect a mouse model asthma. Methods HDAC8 selective inhibitor PCI-34051 was administered ovalbumin-sensitized challenged Airway responsiveness, serum cytokines, histological changes airway, expression levels α-SMA, β-actin, VEGFR, VEGF, GAPDH, HDAC8,...
Qingtian paddy field carp (PF-carp) is a local cultivated in the of Qingtian, Zhejiang. This rice-fish co-culture system has been recognized as one Globally Important Agriculture Heritage Systems (GIAHS). PF-carp acclimatized to high-temperature environment shallow fields after several centuries domestication. To reveal physiological and molecular regulatory mechanisms PF-carp, we chose use 28°C control group 34°C treatment group. We measured biochemical parameters their serum...
Bei den meisten Patienten mit Karpaltunnelsyndrom lässt sich keine Ursache für die Verengung unterhalb des Retinaculum flexorum diagnostizieren. Beim sekundären jedoch findet eine zugrunde liegende Ursache, ggf. ebenfalls behandelt werden muss. Eine taiwanesische Arbeitsgruppe hat nun untersucht, wie häufig sekundäre Karpaltunnelsyndrome durch Raumforderungen im Karpaltunnel verursacht werden.
Abstract Background Neural stem cell (NSC) differentiation is one of many multi-stage lineage systems that require multiple fate decisions. Recent single-cell transcriptome datasets became available at individual differentiation, however, a systematic and integrative analysis temporal points NSC lacking. Results Here we investigate five paths by analyzing comparing four different datasets. By constructing gene regulatory networks for each type, delineate their patterns via analyses...