A5027705934- RNA modifications and cancer
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Cancer-related molecular mechanisms research
Nanjing Medical University
2022-2025
Northwest A&F University
2024
Despite continuous expansion of the RNA binding protein (RBP) world, there is a lack systematic understanding RBPs in mammalian testis, which harbors one most complex tissue transcriptomes. We adapted interactome capture to mouse male germ cells, building an RBP atlas characterized by multiple layers dynamics along spermatogenesis. Trapping RNA-cross-linked peptides showed that glutamic acid-arginine (ER) patch, residue-coevolved polyampholytic element present coiled coils, enhances its host...
Meiosis entry during spermatogenesis requires reprogramming from mitotic to meiotic gene expression profiles. Transcriptional regulation has been extensively studied in meiosis entry, but gain of function for master transcription factors is insufficient down-regulate genes. RNA helicase YTHDC2 and its partner MEIOC emerge as essential posttranscriptional regulators entry. However, it unclear what governs the binding specificity YTHDC2/MEIOC. Here, we identified protein RBM46 a component...