A5003243952- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Diabetes Management and Research
- Advanced Breast Cancer Therapies
- Pancreatic function and diabetes
- Molecular Biology Techniques and Applications
- Hematopoietic Stem Cell Transplantation
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Electrolyte and hormonal disorders
- Hemoglobinopathies and Related Disorders
- CNS Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Mobile Health and mHealth Applications
- Cancer-related Molecular Pathways
- Cardiac tumors and thrombi
- Peptidase Inhibition and Analysis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Xenotransplantation and immune response
- PI3K/AKT/mTOR signaling in cancer
- Mesenchymal stem cell research
- Hormonal Regulation and Hypertension
- Cutaneous lymphoproliferative disorders research
- Nutrition and Health in Aging
- Diabetes Management and Education
Nagoya University
1998-2024
Aichi Cancer Center
2004-2014
Kyoto University
2008
Osaka University
2008
Microbial Chemistry Research Foundation
2008
Higashi Nagoya National Hospital
2004
National Cancer Center Hospital East
2004
Zenyaku Kogyo (Japan)
2004
Sapienza University of Rome
1999
Queen Mary Hospital
1999
Background In recent years, technologies promoting the digitization of self-monitoring blood glucose (SMBG) records including app-cloud cooperation systems have emerged. Studies combining these technological interventions with support from remote health care professionals reported improvements in glycemic control. Objective To assess use an system linked SMBG devices clinical settings, we evaluated its effects on outpatient management diabetes without professional support. Methods this...
The prognosis of patients with primary mediastinal large B-cell lymphoma has improved over recent years. However, the optimal treatment strategy including role radiotherapy remains unknown. We retrospectively analyzed clinical outcomes 345 newly diagnosed in Japan. With a median follow up 48 months, overall survival at four years for treated R-CHOP (n=187), CHOP (n=44), DA-EPOCH-R (n=9), 2nd- or 3rd-generation regimens, and chemotherapy followed by autologous stem cell transplantation were...
Background Classical Hodgkin's lymphoma is characterized by Hodgkin and Reed Sternberg cells, which are of B-cell origin in many cases. We recently highlighted the adverse prognostic significance cytotoxic molecule expression patients with classical lymphoma. However, clinical characteristics molecule-positive remain controversial.Design Methods investigated clinicopathological profiles 32 lymphoma, comprising 23 nodular sclerosis 9 mixed cellularity, compared these those 55 nodal peripheral...
We have previously found that the angiotensin-converting enzyme (ACE) carries GPI-anchored protein releasing activity (GPIase) as well dipeptidase activity. Testicular ACE (tACE), male germinal specific isozyme, plays a crucial role in fertilization. The amino-terminal region of this isozyme is different from somatic (sACE) and contains potential O-linked glycosylation sites. By multiple mutagenesis after an silico prediction, amino acid residues acquiring O-glycans were assigned. Both...
Hyponatremia leads to severe central nervous system disorders and requires immediate treatment in some cases. However, a rapid increase serum sodium (s-Na) concentration could cause osmotic demyelination syndrome. To achieve safety hyponatremia treatment, we develop prediction model of s-Na using machine learning. Among the 341 47 patients admitted two tertiary hospitals for (s-Na <130 mEq/L), those who were general unit with urine <20 mEq/L or treated desmopressin excluded. Ultimately, 74...
AimsIn our previously reported randomized controlled trial in patients with noninsulin-treated type 2 diabetes, the use of flash glucose monitoring (FGM) improved glycated hemoglobin (HbA1c), and improvement was sustained after cessation monitoring. In this post-hoc analysis, we examined data from to identify factors that influenced FGM efficacy.MethodsWe analyzed for 48 49 participants group who completed clarify changes various parameters related HbA1c FGM.ResultsAnalyses during 12-week...
Objective: Resting energy expenditure (REE) decreases if there is reduced intake and body weight (BW). The decrease in REE could make it difficult for patients with obesity to maintain decreased BW. This study aimed investigate the correlation among changes REE, intake, BW during loss process obesity. Materials methods: We conducted a retrospective cohort of hospitalized treatment Japan. Patients received fully controlled [...]
<sec> <title>BACKGROUND</title> In recent years, technologies promoting the digitization of self-monitoring blood glucose (SMBG) records including app-cloud cooperation systems have emerged. Studies combining these technological interventions with support from remote health care professionals reported improvements in glycemic control. </sec> <title>OBJECTIVE</title> To assess use an system linked SMBG devices clinical settings, we evaluated its effects on outpatient management diabetes...
6704 Background: Optimal combination schedule of R-CHOP for untreated FL is still uncertain. Quantitative evaluation MRD may suggest a correlation between the treatment and its outcome. Methods: We conducted randomized phase II study comparing 6 cycles (concurrent; Arm C) CHOP followed by weekly doses rituximab (sequential; S) previously untreated, advanced-stage indolent B-cell lymphoma, mainly consisting FL. DNA bone marrow (BM) peripheral blood (PB) were obtained before (baseline), after...