A5031272341- Cardiac Arrest and Resuscitation
- Cardiac Ischemia and Reperfusion
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Anesthesia and Neurotoxicity Research
- Mechanical Circulatory Support Devices
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Imaging and Diagnostics
- Pharmaceutical Practices and Patient Outcomes
- Medication Adherence and Compliance
- Sarcoidosis and Beryllium Toxicity Research
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parathyroid Disorders and Treatments
- Microfluidic and Capillary Electrophoresis Applications
- Experimental Learning in Engineering
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lipoproteins and Cardiovascular Health
- Neurological disorders and treatments
- Cardiac tumors and thrombi
- Heart Rate Variability and Autonomic Control
United Heart and Vascular Clinic
2024
Minneapolis Heart Institute Foundation
2023
Allina Health
2022
University Hospitals of Cleveland
2021
Case Western Reserve University
2021
University School
2021
University of Minnesota Medical Center
2018-2020
University of Minnesota
2014-2018
Veterans Health Administration
2018
Stuart Olson (Canada)
2015
Irrigation Characteristics and Ablation Lesions Background The delivery of radiofrequency (RF) energy through irrigated ablation catheters may be affected by irrigant osmolarity catheter position. We sought to characterize lesion formation characteristics using different irrigants in both open closed catheter. Methods An ex vivo model consisting viable bovine myocardium a submersible load cell was assembled circulating saline bath at 37 °C. externally were positioned with 10 g force...
Sarcoidosis is a multisystem granulomatous disease that can affect the heart. Early identification of cardiac sarcoidosis (CS) critical because sudden death be initial presentation. We sought to evaluate potential role ECG for involvement in cohort patients with biopsy-proven pulmonary sarcoidosis.Our consisted referred who demonstrated symptoms consistent involvement. The characteristics collected were PR, QRS duration, QT interval, rate, bundle branch block (BBB), fragmented (fQRS)....
Background Patients with pulmonary hypertension caused by chronic lung disease (Group 3 PH ) have disproportionate right ventricle ( RV dysfunction, but the correlates and clinical implications of dysfunction in Group are not well defined. Methods Results We performed a cohort study 147 patients evaluated at University Minnesota. systolic function was quantified using ventricular fractional area change RVFAC + dP /dt max /instantaneous pressure. Tau diastolic stiffness characterized...
Poloxamer 188 (P188) is a nonionic triblock copolymer believed to prevent cellular injury after ischemia and reperfusion.This study compared intracoronary infusion of P188 immediately reperfusion with delayed through peripheral intravenous catheter in porcine model ST segment elevation myocardial infarction (STEMI). Cellular mitochondrial were assessed.STEMI was induced 55 pigs using 45 minutes endovascular coronary artery occlusion. Pigs then randomized four groups: control, immediate (IC)...
xtracorporeal membrane oxygenation (ECMO) is used in cardiopulmonary resuscitation (CPR) of refractory cardiac arrest. We a 2×2 study design to compare ECMO versus CPR and epinephrine placebo porcine model ischemic ventricular fibrillation (VF). Pigs underwent 5 minutes untreated VF, 10 CPR, were randomized receive for another 35 minutes. Animals further LAD reperfusion at minute 45 with ongoing veno-arterial cannulation subsequent reperfusion. Four-hour survival was improved while showed no effect.
Medical records that do not accurately reflect the patient's current medication list are an open invitation to errors and may compromise patient safety.This cross-sectional study compares primary care provider (PCP) lists pharmacy claims for 100 patients seen in 8 practices examines association of congruence with demographic, clinical, practice characteristics. Medication was measured as agreement entire PCP chart, including list, visit notes, correspondence sections.Congruence between chart...
We evaluated the feasibility of optimising coronary perfusion pressure (CPP) during cardiopulmonary resuscitation (CPR) with a closed-loop, machine-controlled CPR system (MC-CPR) that sends real-time haemodynamic feedback to set machine learning and control algorithms which determine compression/decompression characteristics over time.American Heart Association guidelines (AHA-CPR) standard mechanical devices employ "one-size-fits-all" approach fails adjust compressions time or individualise...
Background: Prior investigations have demonstrated increased injury risk on artificial turf at the collegiate and professional levels. However, no prior study has examined this among high school athletics beyond football. The purpose of was to compare incidences versus natural playing surfaces athletes. Methods: Data collected from 26 schools analyzed grass based sport. Analyses were also performed incidence by location (upper extremity, lower torso), sport, level competitive play (freshman,...
Objective : Therapeutic Hypothermia (TH) is thought to improve neurologically intact survival when applied after Return of Spontaneous Circulation (ROSC) achieved in patients who suffer a cardiac arrest.Intra-CPR cooling may accelerate the time reach TH and thus enhance its neurological benefit.Sodium Nitroprusside Enhanced Cardiopulmonary Resuscitation (SNPeCPR) has been shown intra-CPR compared standard CPR.The aim this study assess which method therapeutic hypothermia most efficient...
Isolated heart preparations have the advantage of being void confounding humoral and neuronal input when studying its response to drugs or other interventions. Dynamic changes in left ventricular pressure (LVP) derivatives, coronary flow perfusion pressure, electrocardiogram (ECG), variables can be assessed over time. However, a reliable data acquisition system (DAS) is critical successfully conduct meaningful experiment. Plug‐and‐play DAS often disadvantage limited flexibility because...
Case: Mr M. presented to the emergency room with two months of progressive shortness breath and was found be in atrial flutter 2:1 conduction at a rate 140 bpm. His medical history significant for tobacco use, etoh abuse, hypertension. Key objective findings included tachycardia, hypoxia an elevated JVP, bibasilar crackles, summation gallop, lower extremity edema. work up echocardiogram that illustrated globally depressed EF (15-20%) large “worm like” mass free floating extended into RV....
Introduction: Functional testing of isolated mitochondria is a powerful in vitro tool for determining mitochondrial health following an ischemic stress. Successful preservation intact requires efficient harvest technique under cold conditions. As heart and brain are vital to the success cardiopulmonary resuscitation (CPR), we sought determine consequence co-isolation these organs on cardiac function porcine model arrest. Methods: After 15 min ventricular fibrillation, 36 animals were...
Introduction: Mitochondrial dysfunction is a hallmark of prolonged ischemia, however it’s onset during cardiac arrest (CA) and reperfusion with cardiopulmonary resuscitation (CPR) has yet to be elucidated. In porcine model CA, ischemic postconditioning (IPC) CPR increased neurologically intact survival. We hypothesized that injury, as evidenced by mitochondrial dysfunction, develops rescued IPC. investigated the effect CPR, IPC on function viability. Methods: After 15 min ventricular...
Introduction: Pharmacologic postconditioning with the inhaled anesthetic sevoflurane (SEVO) during cardiopulmonary resuscitation (CPR) has been shown to improve outcomes in a porcine model of prolonged cardiac arrest. Hypothesis: We hypothesized that SEVO works part by improving coronary perfusion pressure (CPP) CPR. Methods: Following 15 min untreated ventricular fibrillation (VF), 16 pigs received mechanical CPR for 4 without (CON) or low- (2 Vol%) high-dose (4 3 min. CPP was measured as...
Introduction Postconditioning during cardiopulmonary resuscitation (CPR) is an effective intervention to improve neurological function and survival in a porcine model of prolonged cardiac arrest (CA). We tested if ischemic (IPoC) anesthetic postconditioning (APoC) decrease reactive oxygen species (ROS) production the brain upon reperfusion with CPR. Methods After 15 min untreated ventricular fibrillation, 10 pigs were randomized receive active compression/decompression CPR IPoC (three 20‐sec...
Introduction: With the shift towards conduction system pacing (CSP), a technique that preserves ventricular synchrony unlike standard right (RVP), use of smaller diameter fixed-helix Medtronic 3830 4Fr Select Secure lead and its’ special delivery catheter has dramatically increased. The near long-term performance in large real-world setting remains poorly characterized. Thus, we evaluated our experience with comparison to 6Fr stylet-driven active fixation CapSureFix Novus 5076 used for...