A5008333094- Cardiac Arrhythmias and Treatments
- Microbial Inactivation Methods
- Cardiac electrophysiology and arrhythmias
- Electrostatic Discharge in Electronics
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Mechanical Circulatory Support Devices
- Anatomy and Medical Technology
- Cardiac and Coronary Surgery Techniques
- Coronary Interventions and Diagnostics
- Peripheral Nerve Disorders
- Cardiac Structural Anomalies and Repair
- Microfluidic and Bio-sensing Technologies
- Soft Robotics and Applications
- Prostate Cancer Diagnosis and Treatment
- Insect and Pesticide Research
- Balance, Gait, and Falls Prevention
- Ultrasound and Hyperthermia Applications
- Cardiac Ischemia and Reperfusion
- Diabetic Foot Ulcer Assessment and Management
- Plasma Applications and Diagnostics
- Anesthesia and Neurotoxicity Research
- Surgical Simulation and Training
- Polymer Nanocomposite Synthesis and Irradiation
- Muscle and Compartmental Disorders
Boston Scientific (United States)
2024-2025
University of Minnesota
2019-2024
Medtronic (Ireland)
2021
Pulsed field ablation is an emerging modality for catheter-based cardiac ablation. The main mechanism of action irreversible electroporation (IRE), a threshold-based phenomenon in which cells die after exposure to intense pulsed electric fields. Lethal threshold IRE tissue property that determines treatment feasibility and enables the development new devices therapeutic applications, but it greatly dependent on number pulses their duration.In study, lesions were generated by applying porcine...
The goal of our study was to determine the importance electric field orientation in an anisotropic muscle tissue for extent irreversible electroporation damage by means experimentally validated mathematical model.Electrical pulses were delivered porcine skeletal vivo inserting needle electrodes so that applied direction either parallel or perpendicular fibres. Triphenyl tetrazolium chloride staining used shape lesions. Next, we a single cell model cell-level conductivity during...
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Abstract As electroporation therapies become more widely used in the cardiac ablation space, there is a critical need to study potential effects on surrounding tissues: collateral damage. Here we explored methods applying electroporative energies vascular smooth muscle: i.e., loss of function when exposed needed induce irreversibly therapy myocardium.
Abstract While thermal ablation to induce pulmonary vein isolation has proven be successful in treating atrial fibrillation, the applied modalities create possibilities for collateral damage surrounding extracardiac structures. Bronchi are considered as one tissue susceptible such damage. Here, relative impacts that focal cryoablation dosages have on bronchial tissues were investigated using an vitro isolated bath setup.
Abstract Epicardial ablations are being utilized as alternative techniques to the current endocardial procedures. An epicardial approach offers some advantages, especially when treating ventricular arrhythmias, e.g., those that have or transmural sites of origin. However potential collateral damage from these applied myocardial surface has not been fully explored. In order better visualize and understand such effects on acute coronary functioning, we employed intracoronary optical coherence...
Robot assisted surgery has been widely accepted by the medical community. Surgeons utilize robots in many different procedures worldwide. However, cardiothoracic surgeons do not regularly use robotic tools to aid them performing even simple, catheter based such as cardiac ablation or mapping. Some Monophasic Action Potentials (MAPs) and catheters require a specific window of force either effectively characterize scar tissue. This is challenging maintain through cycle, so application constant...
Abstract Electroanatomical mapping systems are being utilized clinically for locating arrhythmias within a given patient’s heart. Today, employed endocardial invasive and require extensive set-up time. Epicardial systems, like CardioInsight™ from Medtronic, non-invasive but co-registration of electrodes to the heart, e.g. via required Computed Tomography (CT) scan. This system has been used both in several laboratories situ. The difficulties with vitro uses that ex vivo perfused hearts lack...
Abstract Acute compartment syndrome is a serious condition that requires urgent surgical treatment. While the current emergency treatment straightforward — relieve intra-compartmental pressure via fasciotomy diagnosis often difficult one. A deep neural network presented here has been trained to detect whether isolated muscle bundles were exposed hypoxic conditions and became ischemic.
Abstract Implanting Left ventricular assist devices (LVADs) can be life saving therapies that improve expectancy for the patients receive it. The target patient population suffer from end-stage heart failure and are therefore susceptible to morbidities arising a less than ideal surgical implantation. Importantly, graft carries blood LVAD pump aorta needs sized accordingly so as not cause any compounding complications. current typical method, is perform visual estimation at time of This...
Abstract Computational models and three-dimensional prints were developed to aid in the pre-procedural planning of a LVAD exchange surgery. Clinical imaging was used model segment anatomy implanted device for computational implantation 3D printing. The physicians visualized space better understand device-tissue-interface current implant assess optimal location surgical entry. also contributed education team by providing hands-on tools planned steps involved procedure.
Abstract Irreversible electroporation has regained a new popularity as robust and effective ablation modality. One concern however that remains is the optimization of several parameters to further implement technology in medical therapies; one most important effects mitigation muscle stimulation. Here we present induced contractile force on swine skeletal after delivery irreversible therapies. We aim evaluate two differing waveforms, classic electroporation, IRE, with monophasic DC pulses...