A5007812292- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Boron Compounds in Chemistry
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Radiomics and Machine Learning in Medical Imaging
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Ear and Head Tumors
- Nanoplatforms for cancer theranostics
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Soft tissue tumor case studies
- Lung Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Neuroendocrine Tumor Research Advances
- Cancer Research and Treatments
- Sarcoma Diagnosis and Treatment
- Ocular Oncology and Treatments
- Genetic factors in colorectal cancer
National Institutes for Quantum Science and Technology
2019-2024
Chiba Hospital
2023
The University of Tokyo
2010-2022
University of Tokyo Hospital
2017
The role of artificial intelligence in the diagnosis Helicobacter pylori gastritis based on endoscopic images has not been evaluated. We constructed a convolutional neural network (CNN), and evaluated its ability to diagnose H. infection.A 22-layer, deep CNN was pre-trained fine-tuned dataset 32,208 either positive or negative for (first CNN). Another trained using classified according 8 anatomical locations (secondary A separate test data set (11,481 from 397 patients) by CNN, 23...
The use of convolutional neural networks (CNNs) has dramatically advanced our ability to recognize images with machine learning methods. We aimed construct a CNN that could the anatomical location esophagogastroduodenoscopy (EGD) in an appropriate manner. A CNN-based diagnostic program was constructed based on GoogLeNet architecture, and trained 27,335 EGD were categorized into four major locations (larynx, esophagus, stomach duodenum) three subsequent sub-classifications for (upper, middle,...
Background and aim: We recently reported the role of artificial intelligence in diagnosis Helicobacter pylori (H. pylori) gastritis on basis endoscopic images. However, that study included only H. pylori-positive -negative patients, excluding patients after pylori-eradication. In this study, we constructed a convolutional neural network (CNN) evaluated its ability to ascertain all infection statuses.Methods: A deep CNN was pre-trained fine-tuned dataset 98,564 images from 5236 (742...
High linear energy transfer (LET) radiation carbon-ion radiotherapy (C-ion RT) is one of the most promising modalities for treating unresectable primary pancreatic cancers. However, how LET contributes to a therapeutic effect not clear. To assess whether there an enhanced high on tumour control, we aimed determine impact dose-averaged local control (LC) tumours.A retrospective analysis 18 patients with carcinomas treated definitive C-ion RT concurrent chemotherapy in 2013 was conducted. The...
This feasibility study confirmed the initial safety and efficacy of a novel carbon-ion radiotherapy (CIRT) using linear energy transfer (LET) painting for head neck cancer. is first step toward establishing CIRT with LET in clinical practice making it standard future.
This study aimed to assess the safety and efficacy of carbon-ion radiotherapy (CIRT) for salvage previously X-ray-irradiated (XRT) locally recurrent rectal cancer (LRRC).Between September 2005 December 2017, 77 patients with LRRC were treated CIRT re-irradiation. All had received prior XRT a median dose 50.0 Gy (range 20-74 Gy), principally neoadjuvant or adjuvant recurrence prophylaxis in 34 43 patients. The total 70.4 (RBE) (gray relative biologic effectiveness) was administered 16 fixed...
No standard treatment paradigm exists for previously irradiated locally recurrent rectal cancer (PILRRC). Carbon-ion radiotherapy (CIRT) may improve oncologic outcomes and reduce toxicity compared with combined modality therapy (CMT). Eighty-five patients treated at Institution A CIRT alone (70.4 Gy/16 fx) eighty-six B CMT (30 Gy/15 fx chemoradiation, resection, intraoperative electron (IOERT)) between 2006 2019 were retrospectively compared. Overall survival (OS), pelvic re-recurrence (PR),...
Carbon ion radiotherapy (CIRT) has garnered interest for the treatment of locoregional rectal cancer recurrence. No study compared CIRT and X-ray (XRT) reirradiation (reRT) in such cases. We analyzed clinical outcomes as local control, overall survival, late toxicity rate between XRT, treating Patients with who received reRT to pelvis by or XRT from March 2005 July 2019 were included. The schedule was 70.4 Gy (relative biological effectiveness) 16 fractions. For group, median dose 50 (range...
Perianal hidradenitis suppurativa (PHS) is a chronic recurrent inflammatory disease of the apocrine glands present in skin and soft tissue adjacent to anus. It often misdiagnosed or treatment delayed, resulting formation an abscess or, worst case, leading sepsis. difficult treat perianal lesions merged with fistulae completely due its high recurrence rate. Therefore, we should diagnose it correctly appropriate methods.We report two cases PHS anal that were examined preoperatively using...
Patients who receive carbon-ion radiotherapy (C-ion RT) for primary pancreatic cancer may experience locoregional recurrence; however, the treatment options such patients are limited. We aimed to investigate feasibility and efficacy of re-irradiation with experienced recurrence after initial C-ion RT.Twenty-one recurrent underwent repeat RT between December 2010 November 2016 at our institute were retrospectively evaluated. The sites post-initial failure in-field central in 16 (76.2%)...
Accurate diagnosis of colorectal premalignant polyps, including adenomas, is vital in clinical practice.To investigate the diagnostic yields novel findings brown slits for adenomas.Patients who underwent colonoscopy at Toyoshima Endoscopy Clinic were enrolled. Polyps sized ≥ 5 mm suspected adenomas or clinically significant serrated polyps included study. We defined surface structures which curves inside and along tubular glands identified using a combination new X1 system (Olympus...
Abstract Background Locally recurrent rectal cancer (LRRC) involving the upper sacrum is typically incurable, and palliative treatment only option for most patients, resulting in a poor prognosis reduced quality of life. Carbon ion radiotherapy (CIRT) has emerged as promising modality treating LRRC. This report presents case LRRC with sacral involvement that was managed via multidisciplinary therapy incorporating CIRT. Case presentation A 55-year-old male diagnosed an anastomotic recurrence...
Background: The expression of doublecortin-like kinase 1 (DCLK1) has been investigated in cancer; however not precancerous adenomatous polyps. Materials and Methods: Immunohistological DCLK1 was evaluated various grades adenomas, cancerous polyps, hyperplastic polyps resected human tissue specimens. Results: Ninety-two specimens were positive for 134 negative. Cancerous showed a high positivity rate compared to adenomas (68.4% vs. 36.8%; p<0.01). significantly different among the three...
We report our experience involving a case of relatively rare anorectal malignant melanoma with skipped lesion.The patient was 72-year-old man who had visited local clinic complaining mass in the anal region, whereupon he referred to hospital on suspicion melanoma. Close examination revealed 25-mm black type 1 tumor one-third size circumference canal and located externally it. performed transanal resection confirmed diagnosis Notably, multiple macular lesions spaced away from main lesion were...
Background: Adjuvant chemotherapy (AC) is known to be beneficial for stage III colorectal cancer (CRC). In contrast, only a few studies have reported the survival benefits of AC IV CRC after curative surgery. Methods: We identified 155 patients with various organ metastases who underwent surgery in our hospital between 2003 and 2017. Clinicopathological parameters postoperative were reviewed. Multivariate analyses performed identify prognostic factors. Moreover, effects on recurrence-free...
Secondary metastasis to regional lymph nodes for adjacent bowel invaded by colorectal cancers (CRCs) has not been extensively reviewed. We herein present three such cases. The first case is a cancer involving the cecum and sigmoid colon, its primary site could be determined even pathological evaluation. Nodal involvement was revealed both in mesocolon of sigmoid. second third cases are colon invading jejunum an ascending jejunum, respectively. These patients harbored secondary metastases...
Chordoma is a rare, locally invasive neoplasm of the axial skeleton. Complete resection often difficult, especially for upper-cervical (C1-2) spine. We evaluated efficacy and safety carbon-ion radiotherapy (CIRT) unresectable C1-2 chordoma.Patients with chordoma treated definitive CIRT (60.8 Gy [RBE] in 16 fractions) were retrospectively analyzed. OS, LC, PFS, toxicity.Nineteen eligible patients all completed planned course CIRT. With median follow-up 68 months (range: 29-144), OS was 126...
The neoadjuvant therapy for locally advanced rectal cancer has been changed from radiotherapy (RT) to chemoradiotherapy (CRT). This study is aimed at evaluating the benefit of CRT in patients with stage II or III lower cancer, regard impact on recurrence.A total 474 clinical who received either preoperative RT (n = 221) 253) followed by mesorectal excision were identified our institutional database. Propensity score analysis was performed mitigate selection biases.Among patients, group...