A5100618617- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Mobile Health and mHealth Applications
- Nutritional Studies and Diet
- Context-Aware Activity Recognition Systems
- Fatty Acid Research and Health
- Sleep and Wakefulness Research
- Radiomics and Machine Learning in Medical Imaging
- Sleep and related disorders
- Eating Disorders and Behaviors
- Amino Acid Enzymes and Metabolism
- Porphyrin Metabolism and Disorders
- Software Engineering Research
- Ovarian function and disorders
- Folate and B Vitamins Research
- Cutaneous Melanoma Detection and Management
- Indoor and Outdoor Localization Technologies
- Healthcare and Venom Research
- Digital Mental Health Interventions
- Traditional Chinese Medicine Studies
- Nitric Oxide and Endothelin Effects
- Infection Control in Healthcare
- Heart Rate Variability and Autonomic Control
- Interactive and Immersive Displays
- Mental Health Research Topics
University of Washington
2019-2024
City Of Hope National Medical Center
2021-2022
City of Hope
2022
Grinnell College
2020
Houston Fertility Institute
2020
Georgia Institute of Technology
2018
Harvard University
2016
Brigham and Women's Hospital
2016
University of Chicago
2014
University of Louisville
2004-2009
Sleep fragmentation (SF) is a common occurrence and constitutes major characteristic of obstructive sleep apnea (OSA). SF has been implicated in multiple OSA-related morbidities, but it unclear whether underlies any the cardiovascular morbidities OSA. We hypothesized that long-term exposures may lead to endothelial dysfunction altered vessel wall structure. Adult male C57BL/6J mice were fed normal chow exposed daylight or control (CTL) for 20 weeks. Telemetric blood pressure function...
Mental health issues, which can be difficult to diagnose, are a growing concern worldwide. For effective care and support, early detection of mood-related concerns is paramount importance. Typically, survey based instruments including Ecologically Momentary Assessments (EMA) Day Reconstruction Method (DRM) the method choice for assessing mood related health. While effective, these methods require some effort thus both compliance rates as well quality responses limited. As an alternative, We...
The intermittent hypoxia (IH) that characterizes sleep-disordered breathing impairs spatial learning and increases NADPH oxidase activity oxidative stress in rodents. We hypothesized green tea catechin polyphenols (GTPs) may attenuate IH-induced neurobehavioral deficits by reducing expression, lipid peroxidation, inflammation.To assess the effects of GTP administered drinking water on cognitive, inflammatory, responses to long-term (>14 d) IH during sleep male Sprague-Dawley rats.Cognitive...
Specific antimicrobial antibodies present in the sera of patients with inflammatory bowel disease (IBD) have been proven to be valuable serological biomarkers for diagnosis/prognosis disease. Herein we describe use a whole Escherichia coli proteome microarray as novel high throughput proteomics approach screen and identify new IBD. Each protein array, which contains 4,256 E. K12 proteins, was screened using individual serum from healthy controls (n = 39) clinically well characterized IBD (66...
Exposure to intermittent hypoxia, such as occurs in sleep-disordered breathing, is associated with oxidative stress, cognitive impairments, and increased neuronal apoptosis brain regions involved learning memory. Apolipoprotein E (ApoE) has been implicated neurodegenerative disorders, vitro studies suggest that one of the functions ApoE may be confer protection from oxidant stress-induced cell loss. Therefore, we hypothesized ApoE-deficient (ApoE−/−) mice would display impairments following...
Abstract Intermittent hypoxia (IH) during sleep, a hallmark of sleep apnea, is associated with neurobehavioral impairments, regional neurodegeneration and increased oxidative stress inflammation in rodents. Platelet‐activating factor (PAF) an important mediator both normal neural plasticity brain injury. We report that mice deficient the cell surface receptor for PAF ( PAFR –/–), bioactive inflammation, are protected from spatial reference learning deficits IH. Furthermore, –/– exhibit...
Large language models (LLMs) have shown remarkable abilities to generate code. However, their ability develop software for physical computing and embedded systems, which requires cross-domain hardware knowledge, has not been thoroughly studied. We observe through our experiments a 15-user pilot study that even when LLMs fail produce working code, they can helpful reasoning about design tasks, as well specific debugging suggestions both novice expert developers. These results highlight the...
Washing hands is one of the easiest yet most effective ways to prevent spreading illnesses and diseases. However, not adhering thorough handwashing routines a substantial problem worldwide. For example, in hospital operations lack hygiene leads healthcare associated infections. We present WristWash, wrist-worn sensing platform that integrates an inertial measurement unit Hidden Markov Model-based analysis method enables automated assessments according recommendations provided by World Health...
Background Eating behavior has a high impact on the well-being of an individual. Such involves not only when individual is eating, but also various contextual factors such as with whom and where eating what kind food eating. Despite relevance factors, most automated detection systems are designed to capture factors. Objective The aims this study were (1) design build smartwatch-based system that can detect meal episodes based dominant hand movements, (2) ecological momentary assessment (EMA)...
Deviant eating behavior such as skipping meals and consuming unhealthy has a significant association with mental well-being in college students. However, there is more to what an individual eats. While patterns form critical component of their well-being, insights assessments related the interplay remain under-explored theory practice. To bridge this gap, we use existing real-time detection system that captures context during examine how students’ associates particularly affect, anxiety,...
Human embryos are usually cultured to blastocyst stage by Day 5 or 6 after insemination. However, some grow slowly and reach at 7. Acceptable live birth rates have been reported transfer of 7 blastocysts resulted from fresh oocyte in vitro fertilization (IVF). It is unknown whether an extended embryo culture necessary for cryopreserved IVF obtain more transferrable blastocysts.In this study, 455 oocytes 57 cycles were warmed, inseminated, the resulting examine development culture. Fifty one...
INTRODUCTION: We compared critical flicker frequency (CFF) thresholds obtained using a novel portable device “Beacon” with from the commercially available Lafayette Flicker Fusion System (Lafayette-FFS) in patients cirrhosis. METHODS: One hundred fifty-three participants chronic liver disease underwent CFF testing Beacon and Lafayette-FFS method-of-limits and/or forced-choice protocol. RESULTS: demonstrated excellent test-retest reliability (intraclass correlation 0.91–0.97) good values...
Using multiple devices to exploit their strengths and mechanics for a task is referred as "migration." However, re-establishing context upon moving from one device another can be cumbersome. We propose opportunistic nudges way more seamlessly share content between personal devices. Opportunistic appear in the bezel when migration occurs interacted with quickly files applications. if user ignores them, they automatically disappear after some time. explore design space of through rapid...
We present AdHocProx, a system that uses device-relative, inside-out sensing to augment co-located collaboration across multiple devices, without recourse externally-anchored beacons – or even reliance on WiFi connectivity.
We propose Smart-Pikachu, a stuffed animal equipped with sensing and actuation to explore the use of large language models (LLM's) sensor data inputs. The augmentation pressure will allow for LLM interpret various interactions such as hugs handshakes user. Furthermore, capabilities extend our system's interactivity by providing physical feedback also incorporate text-to-speech output from add another mode interaction between system In this Student Innovation Challenge, we intend applications...
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism that binds flavin adenine dinucleotide (FAD) and uses NAD(P)H to catalyze the conversion of 5,10‐methylenetetrahydrofolate 5‐methyltetrahydrofolate by ping‐pong Bi‐Bi mechanism. The x‐ray crystal structure FAD ‐ bound E. coli has revealed hydrogen bonding network involves amino acid residues Ser26, His273, Glu28, structural water molecule, N10 folate. Based on previous studies confirmed importance Glu28...