A5077229664- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Angiogenesis and VEGF in Cancer
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Sulfur Compounds in Biology
- Glycosylation and Glycoproteins Research
- Cardiac Structural Anomalies and Repair
- Galectins and Cancer Biology
- Barrier Structure and Function Studies
- Neonatal Respiratory Health Research
- High Altitude and Hypoxia
- TGF-β signaling in diseases
- Kruppel-like factors research
- Metabolism and Genetic Disorders
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Biomedical Ethics and Regulation
- Endoplasmic Reticulum Stress and Disease
- Hippo pathway signaling and YAP/TAZ
- Microbial Metabolic Engineering and Bioproduction
- Cellular Mechanics and Interactions
- Probiotics and Fermented Foods
- Liver physiology and pathology
TrueBinding (United States)
2022
Synlogic (United States)
2021
Boston University
2016-2020
Yale University
2013-2018
Harvard University
2017
Ospedale Policlinico San Martino
2012-2013
University of Genoa
2011-2013
An engineered microenvironment supports expansion of adult human liver tissue after implantation in a mouse model injury.
Significance Organ homeostasis requires integrity of blood vessels; alterations or disruption the vascular barrier between and tissue contribute to numerous diseases. Endothelial cells mural are two key cell types, which play significant roles for maintenance function. Here, we present a 3D bicellular model mimic this function study role in inflammation. Importantly, by using identified RhoA, Rac1, N -cadherin as important regulators mural–endothelial cell-mediated Given recognized...
In phenylketonuria (PKU) patients, a genetic defect in the enzyme phenylalanine hydroxylase (PAH) leads to elevated systemic (Phe), which can result severe neurological impairment. As treatment for PKU, Escherichia coli Nissle (EcN) strain SYNB1618 was developed under Synlogic's Synthetic Biotic™ platform degrade Phe from within gastrointestinal (GI) tract. This clinical-stage engineered expresses Phe-metabolizing ammonia lyase (PAL), catalyzing deamination of non-toxic product...
Skin flaps are routinely used in surgery for the functional and cosmetic repair of wounds or disfiguring scars. The recent concept therapeutic angiogenesis has emerged as an attractive approach to overcome problem blood supply deficiency, often resulting flap grafting failure. In present study, we embedded a gelatin membrane with amniotic fluid stem cells (AFSC) derived conditioned media (ACM) topically deliver angiogenic growth factors cytokines into rat model ischemic full-thickness skin...
Angiogenic sprouting is a critical process involved in vascular network formation within tissues. During sprouting, tip cells and ensuing stalk migrate collectively into the extracellular matrix while preserving cell–cell junctions, forming patent structures that support blood flow. Although several signaling pathways have been identified as controlling it remains unclear to what extent this mechanoregulated. To address question, we investigated role of cellular contractility sprout...
HPV (Human papillomavirus) affects 600,000 people worldwide each year. Almost all cervical cancers are associated with a past infection. In particular, the positivity to high-risk type HPV16 is detected in most of invasive cancers. FDA has approved prophylactic vaccines that protect against new infections, but do not induce immunity those patients established infections or neoplasms. To date, no therapeutic vaccine targeting HPV16-associated lesions been authorized. We have developed an...
Objective: Angiogenesis is crucial to maintain tissue homeostasis under nutrient and oxygen deprivation (ischemia). Although considerable evidence supports that angiogenesis regulated by hypoxia-HIF1α induction of vascular endothelial growth factor (VEGF), the role in poorly defined. Approach Results: We report form dietary sulfur amino acid restriction (Methionine/cysteine Restriction; MR) promotes VEGF expression functional new capillaries skeletal muscle mice (Fig.1 A, B). This occurred...
Abstract Characterized by rapid growth and diffusely infiltrative spread, glioblastoma (GBM) is the most common malignant primary brain cancer with a very poor prognosis standard of care that hasn’t been improved in over 15 years. The need for new therapies can directly or indirectly target heterogeneous tumor cell populations to inhibit migration addition proliferation highlighted recent efforts develop targeted treat vast majority GBM patients whose tumors impede gross-total resection...
Abstract About 43,600 women in the U.S. are expected to die 2021 from breast cancer. Triple negative cancer (TNBC), which accounts for approximately 15% of all cancers, is diagnosed by exclusion expression and/or amplification three biomarkers (estrogen receptor [ER], progesterone [PR], and human epidermal growth factor 2 [HER2]).Characterized a high risk relapse (one half patients with early stages experience recurrence), short overall survival progression-free (life expectancy few months...