A5004151812- Chronic Kidney Disease and Diabetes
- Retinal Diseases and Treatments
- Diabetes Management and Research
- Diabetes and associated disorders
- Renal Diseases and Glomerulopathies
- Thyroid Cancer Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Pituitary Gland Disorders and Treatments
- Nutrition and Health in Aging
- GDF15 and Related Biomarkers
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutritional Studies and Diet
- Inhalation and Respiratory Drug Delivery
- Adipose Tissue and Metabolism
- Asthma and respiratory diseases
- Cardiovascular Function and Risk Factors
- Growth Hormone and Insulin-like Growth Factors
- Cultural Competency in Health Care
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Thyroid Disorders and Treatments
- Retinopathy of Prematurity Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
Joslin Diabetes Center
2019-2025
Harvard University
2019-2025
Philippine General Hospital
2013-2022
University of the Philippines Manila
2016-2021
Columbus Center
2021
Yahoo (United Kingdom)
2016-2017
Diabetes Australia
2017
Royal College of Physicians
2016
BACKGROUND. In the Joslin Medalist Study (Medalists), we determined whether significant associations exist between β cell function and pathology clinical characteristics.
Diabetic nephropathy (DN) arises from systemic and local changes in glucose metabolism hemodynamics. We have reported that many glycolytic mitochondrial enzymes, such as pyruvate kinase M2 (PKM2), were elevated renal glomeruli of DN-protected patients with type 1 2 diabetes. Here, mice PKM2 overexpression specifically podocytes (PPKM2Tg) generated to uncover the protective function PPKM2Tg a potential therapeutic target prevented albumin/creatinine ratio (ACR), mesangial expansion, basement...
Insulin resistance (IR) can increase atherosclerotic and cardiovascular risk by inducing endothelial dysfunction, decreasing nitric oxide (NO) production, accelerating arterial inflammation. The aim is to determine the mechanism which insulin action NO production in cells improve systemic bioenergetics decrease atherosclerosis via differentiation of perivascular progenitor (PPCs) into brown adipocytes (BAT).Studies used various transgenic deletion mutant ApoE-/- mice receptors, eNOS...
BACKGROUND. We aimed to characterize factors associated with the under-studied complication of cognitive decline in aging people long-duration type 1 diabetes (T1D).
<p dir="ltr">Anti-vascular endothelial growth factor (anti-VEGF) therapies are effective treatment of severe diabetic retinopathy (DR) and macular edema, but a significant subset people showed inadequate response to anti-VEGF intervention. Since elevation or overexpressing retinol binding protein 3 (RBP3) decreased risks for retinal pathologies progression DR, we compared the therapeutic profile RBP3 normalize dysfunctions induced by diabetes. Intravitreous injection recombinant human...
<p dir="ltr">Anti-vascular endothelial growth factor (anti-VEGF) therapies are effective treatment of severe diabetic retinopathy (DR) and macular edema, but a significant subset people showed inadequate response to anti-VEGF intervention. Since elevation or overexpressing retinol binding protein 3 (RBP3) decreased risks for retinal pathologies progression DR, we compared the therapeutic profile RBP3 normalize dysfunctions induced by diabetes. Intravitreous injection recombinant human...
Anti-vascular endothelial growth factor (anti-VEGF) therapies are effective treatment of severe diabetic retinopathy (DR) and macular edema, but a significant subset people showed inadequate response to anti-VEGF intervention. Since elevation or overexpressing retinol binding protein 3 (RBP3) decreased risks for retinal pathologies progression DR, we compared the therapeutic profile RBP3 normalize dysfunctions induced by diabetes. Intravitreous injection recombinant human (rhRBP3) antibodies...
Cognitive dysfunction is a growing and understudied public health issue in the aging type 1 diabetic population difficult time-consuming to diagnose. Studies long duration diabetes have reported presence of proliferative retinopathy was associated with cognitive dysfunction.
Background: No previous studies have been published on poorly differentiated thyroid carcinoma (PDTC) in Southeast Asia.Methods: We included all adult PDTC patients diagnosed using the Turin criteria at Philippine General Hospital from 2006 to 2015.The data collected demographics, clinical presentation, histopathology, treatment, and outcomes.Tests of association were employed compare these with foreign PDTC, as well local (WDTC) anaplastic (ATC).Results: Eighteen cases identified.The median...
Background: Determining risk factors for diabetes insipidus (DI) after pituitary surgery is important in improving patient care.Our objective to determine the associated with DI surgery.Methods: We reviewed records of patients who underwent from 2011 2015 at Philippine General Hospital.Patients preoperative were excluded.Multiple logistic regression analysis was performed and a predictive model generated.The discrimination abilities individual variables assessed using receiving operator...
Type 1 diabetes (T1D) is associated with an increased risk of hip fracture beyond what can be explained by reduced bone mineral density, possibly due to changes in material from accumulation advanced glycation end-products (AGEs) and altered matrix composition, though data human cortical T1D are limited. The objective this study was evaluate behavior examining specimens cadaveric femora older adults long-duration (≥50 yr; n = 20) age- sex-matched nondiabetic controls (n 14). Cortical...
To develop and validate a self-reported sunlight exposure questionnaire (SEQ) for urban adult Filipinos.The study included adults (19-76 years old) in Metro Manila, Philippines, well-versed the Filipino (Tagalog) language had resided Manila at least 1 year. Exclusion criteria pregnancy, active skin disorders, immunocompromised states. An expert panel created Likert-scale format based on conceptual framework 4 existing instruments. The proceeded phases: item development, translation...
Tuberculous (TB) lymphadenitis can mimic cervical node metastasis from papillary thyroid carcinoma (PTC) since the distribution and appearance of affected lymph nodes are similar. We present case an asymptomatic 50-year-old Filipino who sought consult for a gradually enlarging anterior neck mass single palpable node. Preoperative workup suggested malignancy with nodal metastasis. He underwent total thyroidectomy dissection where histopathology confirmed follicular variant- (FV-) PTC. Lymph...
Haemophagocytic lymphohistiocytosis (HLH) is a rare syndrome of pathological immune activation characterised by extreme inflammation. We present case young Filipino man consulting for non-specific symptoms fever, body malaise and weight loss. Prominent physical examination findings included gross pallor, cachexia hepatosplenomegaly. Laboratory results revealed pancytopaenia, while bone marrow haemophagocytosis. Further workup HLH showed hypertriglyceridaemia, hypofibrinogenaemia...
Psychiatric disturbances can manifest after levothyroxine (LT4) treatment for severe hypothyroidism. We present the case of a young Filipino man with Hashimoto's thyroiditis and high-grade heart block, who was given full replacement LT4 dose on admission. Twenty-four hours this dose, he developed manic symptoms, which were addressed sedatives neuroleptics gradual restoration euthymia following day. A comprehensive workup did not reveal any findings suggestive another aetiology either mania...
To determine the association of different levels sunlight exposure, measured using Filipino exposure questionnaire (SEQ) with 25-hydroxyvitamin D (25-OHD) among working urban adult Filipinos.Seventy-five participants, living and in Metro Manila, for at least 1 year, were grouped according to their perceived pattern: low (mostly indoor work); moderate (both outdoor high work). After completion self-administered SEQ, they underwent serum 25-OHD level determination. Strength correlation between...
Pericardial effusion is a rare complication of Graves’ disease. A pregnant Filipino woman with diffuse goiter and hyperthyroid symptoms was initially treated as case She readmitted for exertional dyspnea, orthopnea, bipedal edema; an echocardiogram revealed massive pericardial effusion. Workup other causes the unremarkable. The resolved after pericardiostomy anti-thyroid medications. This highlights clinician’s role in determining association between two disease entities.
Culturally tailored interventions may reduce disparities in diabetes care. We conducted a nationally representative assessment of self-reported cultural competency measures care among patients with the United States.The 2017 National Health Interview Survey was queried for adults diabetes. Sample weight-adjusted multivariable logistic regressions defined adjusted odds ratios and 95% confidence intervals positive response to each while controlling relevant sociodemographic variables.2,448...
Abstract Disclosure: M. Yu: None. S. Jangolla: N. Ziemniak: E. Viebranz: T. Chokshi: K. Park: I. Wu: H. Shah: G.L. King: Cardiovascular disease (CVD) is a major cause of mortality in people with Type 1 diabetes (T1D), especially those nephropathy (DN). However, long-duration T1D, substantial proportion individuals without DN still exhibit excessive CVD risks. The Joslin 50-Year “Medalist” Study (n=1043), composed T1D≥50 years, are ideal for studying renoprotected T1D cohort, as only 13% have...