A5020844750- Retinal Diseases and Treatments
- Diabetes Management and Research
- Retinal Imaging and Analysis
- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Frailty in Older Adults
- Diabetes and associated disorders
- Amino Acid Enzymes and Metabolism
- Cardiovascular Disease and Adiposity
- Pancreatic function and diabetes
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Paraoxonase enzyme and polymorphisms
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Health and Disease Prevention
- Intensive Care Unit Cognitive Disorders
- Colorectal Cancer Screening and Detection
- Nutritional Studies and Diet
- GDF15 and Related Biomarkers
- Geriatric Care and Nursing Homes
- ATP Synthase and ATPases Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hormonal Regulation and Hypertension
- Patient-Provider Communication in Healthcare
- Blood Pressure and Hypertension Studies
Beth Israel Deaconess Medical Center
2023-2025
Harvard University
2023-2025
Joslin Diabetes Center
2019-2021
University of Pennsylvania Health System
2013
BACKGROUND. In the Joslin Medalist Study (Medalists), we determined whether significant associations exist between β cell function and pathology clinical characteristics.
A subset of people with long-standing type 1 diabetes (T1D) appears to be protected from microvascular and macrovascular complications. Previous studies have focused on improved abilities respond glucose its downstream effects as protective mechanisms. It is unclear whether lipoproteins play a role in the vascular health these people. We therefore determined HDL particle concentration, size, function, and/or protein composition associate protection complications.We studied two independent...
Cognitive dysfunction is a growing and understudied public health issue in the aging type 1 diabetic population difficult time-consuming to diagnose. Studies long duration diabetes have reported presence of proliferative retinopathy was associated with cognitive dysfunction.
Guidelines recommend shared decision making (SDM) for mammography screening women ≥ 75 and not with < 10-year life expectancy. High-quality SDM requires consideration of women's breast cancer (BC) risk, expectancy, values but is hard to implement because no models simultaneously estimate older individualized BC risk
Social determinants of health (SDOH) have been associated with numerous medical conditions, including postoperative delirium—a common, morbid, and costly geriatric syndrome characterized by an acute confusional state.1 Individual-level SDOH (e.g., lower income) neighborhood-level greater area deprivation index [ADI]) delirium incidence severity2, 3; however, the underlying biological mechanisms linking these factors remain unclear. Based on our conceptual model (see Figure 1), we hypothesize...
To support mammography screening decision making, we developed a competing-risk model to estimate 5-year breast cancer risk and 10-year nonbreast death for women aged 55 years older using Nurses' Health Study data examined performance in the Black Women's (BWHS). Here, examine predicting outcomes BWHS, Initiative-Extension (WHI-ES), Multiethnic Cohort (MEC) compare existing prediction models.
Abstract Background: Esophageal Adenocarcinoma (EAC) continues to rise in incidence, with prognosis remaining poor despite advances multimodality therapy. Several novel target agents are now being explored as an option for treating EAC. One potential is heat shock protein 90 (Hsp90), a chaperone that involved many diverse biological processes including cell signaling, proliferation, and survival. Many of the client proteins known oncoproteins allow Hsp90 stabilize cancer growth by supporting...
Cognitive impairment, micro and macrovascular complications contribute to the high morbidity mortality of type 1 diabetes (T1D) in an aging population. The dietary inflammatory index (DII), a validated measure potential nutrients, has not been evaluated for its relationship T1D. To this end, semiquantitative food frequency questionnaires were administered at baseline 591 individuals Joslin 50-year Medalist Study (“Medalists”), well-characterized cohort having ≥50 years DII score was derived...
Background: When treating older women with breast cancer, life expectancy is an important consideration. ASCO recommends calculating 10-year mortality probabilities to inform treatment decisions. One useful tool the Schonberg index, which predicts risk-based all-cause mortality. We investigated use of this index in aged ≥65 years cancer Women’s Health Initiative (WHI). Methods: calculated risk scores for 2,549 WHI participants (“cases”) and age-matched cancer–free (“controls”) using scoring....
Mitochondrial abnormalities induced by diabetes have been postulated to cause several complications including nephropathy. Elevated expressions of enzymes for glycolysis and mitochondrial functions in the glomeruli associated with protection against development diabetic nephropathy chronic duration. Activation a glycolytic enzyme, pyruvate kinase M2 (PKM2), small molecule selective activator (TEPP-46) or its targeted overexpression podocytes mice reversed glomerular dysfunction pathology...
The Joslin Medalist Study, which characterizes people with type 1 diabetes duration of 50 years or more, reported that the levels Retinol Binding Protein 3 (RBP3) are increased in retina and vitreous Medalists who protected from development severe diabetic retinopathy (DR). This protective capacity RBP3 is potentially mediated by its ability to delay uptake glucose into cells retinal vasculature neural hyperglycemia. study correlated relationship between DR severity layer thickness serum a...
In the Joslin Medalist Study (“Medalists”), which enrolled people with ≥50 years of type 1 diabetes (T1D), factors have been shown to individually protect against vascular complications, such as proliferative retinopathy (PDR), and possibly, cardiovascular disease (CVD). However, shared protective these outcomes not demonstrated. Recently, Medalists underwent cardiac computed tomography (CT; n=67) magnetic resonance imaging (CMR; n=54) for assessment coronary artery calcification (CAC)...
The risk of cognitive dysfunction in aging populations with type 1 diabetes (T1D) may be similar to that people 2 diabetes, but it has not been well-characterized clinically. In the Joslin Medalist Study, a cohort ≥ 50 years T1D, was previously shown correlate cardiovascular disease (CVD) and proliferative diabetic retinopathy (PDR). subset (n=129), we extended these findings by assessing relationships changes other complications vascular abnormalities retina, developmental extension central...
Cardiovascular disease (CVD) is a major cause of mortality in long-duration type 1 diabetes (T1D) despite the absence nephropathy (DN). However, its mechanisms are incompletely understood. Joslin 50-Year “Medalists”, with T1D≥50 years, ideal for studying CVD renoprotected T1D cohort, as only 13% have DN, yet 40% CVD. A Medalist subset underwent coronary artery calcification scans (CAC; n=75) and cardiac magnetic resonance (CMR; n=60) left ventricular (LV) mass volumes. In exploratory...