A5004985863- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Vibrio bacteria research studies
- Bacteriophages and microbial interactions
- SARS-CoV-2 and COVID-19 Research
- 3D Printing in Biomedical Research
- Aquaculture disease management and microbiota
- Plant Virus Research Studies
- Animal Virus Infections Studies
- Tissue Engineering and Regenerative Medicine
- COVID-19 Clinical Research Studies
- Nerve injury and regeneration
- RNA and protein synthesis mechanisms
- vaccines and immunoinformatics approaches
- Neuroscience and Neuropharmacology Research
- Water Treatment and Disinfection
- Growth Hormone and Insulin-like Growth Factors
- Muscle Physiology and Disorders
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Developmental Biology and Gene Regulation
- Innovative Microfluidic and Catalytic Techniques Innovation
- Olfactory and Sensory Function Studies
- Ubiquitin and proteasome pathways
- Mosquito-borne diseases and control
BRAC University
2019-2024
Gazipur Agricultural University
2022
International Centre for Diarrhoeal Disease Research
2005-2021
Independent University
2019-2021
Kumamoto University
2007-2015
Genetic Resources Center
2009
Kumamoto Health Science University
2009
National Institute of Cholera and Enteric Diseases
2005
The relationship among ( i ) the local incidence of cholera, ii prevalence in aquatic environment Vibrio cholerae , and iii bacterial viruses that attack potentially virulent O1 O139 serogroup strains this organism (cholera phages) was studied Dhaka, Bangladesh. Over nearly a 3-year period, we found significantly more environmental water samples contained either phage or phage-susceptible V. strain than both P < 0.00001). number cholera patients varied seasonally during period frequently...
Axon guidance proteins are critical for the correct wiring of nervous system during development. Several axon cues and their family members have been well characterized. More unidentified assumed to participate in formation extremely complex system. We identified a secreted protein, draxin, that shares no homology with known cues. Draxin inhibited or repelled neurite outgrowth from dorsal spinal cord cortical explants vitro. Ectopically expressed draxin growth caused misrouting chick...
Abstract Predation by bacteriophages can significantly influence the population structure of bacterial communities. Vibrio cholerae causative agent cholera epidemics interacts with numerous phages in aquatic ecosystem, and intestine patients. Seasonal reportedly collapse due to predation pathogen phages. However, it is not clear how sufficient number bacteria survive seed environment subsequent epidemic season. We found that cell density-dependent gene expression termed “quorum sensing”...
Draxin, a recently identified axon guidance protein, is essential for the formation of forebrain commissures, and can mediate repulsion netrin-stimulated spinal commissural axons. Here, we report that draxin binds multiple netrin receptors: DCC (deleted in colorectal cancer), Neogenin, UNC5s (H1, H2, H3), DSCAM (Down's syndrome cell adhesion molecule). Since Dcc knockouts showed similar phenotype commissures formation, show here functional importance draxin/DCC interaction. Draxin interacts...
The emergence of Omicron (B.1.1.529), a new Variant Concern in the COVID-19 pandemic, while accompanied by ongoing Delta variant infection, has once again fueled fears infection wave and global health concern. In variant, receptor-binding domain (RBD) its spike glycoprotein is heavily mutated, feature critical for transmission rate virus interacting with hACE2. this study, we used combination conventional advanced neural network-based silico approaches to predict how these mutations would...
Abstract The thalamocortical tract carries sensory information to the neocortex. It has long been recognized that neocortical pioneer axons of subplate neurons are essential for development. Herein we report an axon guidance cue, draxin, is expressed in early-born neurons, including and necessary In draxin −/− mice, do not enter This phenotype sufficiently rescued by transgenic expression neurons. Genetic interaction data suggest acts through Deleted colorectal cancer (DCC) Neogenin (Neo1),...
The COVID19 pandemic caused by SARS-CoV-2 virus has severely affected most countries of the world including Bangladesh. We conducted comparative analysis publicly available whole-genome sequences 64 isolates in Bangladesh and 371 from another 27 to predict possible transmission routes genomic variations among viruses. Phylogenetic indicated that pathogen was imported multiple countries. viruses found southern district Chattogram were closely related strains Saudi Arabia whereas those Dhaka...
Respiratory syncytial virus (RSV) is a common respiratory pathogen that causes mild cold-like symptoms and severe lower tract infections, causing hospitalizations in children, the elderly immunocompromised individuals. Due to genetic variability, this life-threatening pneumonia bronchiolitis young infants. Thus, we examined 3600 whole genome sequences submitted GISAID by 31 December 2022 examine variability of RSV. While RSVA RSVB coexist throughout RSV seasons, more prevalent, fatal,...
Abstract CRISPR-Cas (clustered regularly interspersed short palindromic repeats-CRISPR-associated proteins) are microbial nuclease systems involved in defense against phages. Bacteria also resist phages by hosting phage-inducible chromosomal islands (PICI) which prevent phage reproduction. Vibrio cholerae causes cholera epidemics, interacts with numerous the environment and patients. Although usually carried bacteria archea, recently V . specific ICP1 were found to host a system that...
In cholera-endemic areas, toxigenic Vibrio cholerae persist in the aquatic ecosystem mostly a biofilm-associated state which bacteria remain embedded an exopolysaccharide matrix. The cells often enter into dormant form referred to as conditionally viable environmental (CVEC), resist cultivation on routine bacteriological media. However, these can naturally resuscitate active planktonic through various mechanisms, multiply, and cause epidemics of cholera. This study was conducted possible...
KSF-1phi, a novel filamentous phage of Vibrio cholerae, supports morphogenesis the RS1 satellite by heterologous DNA packaging and facilitates horizontal gene transfer. We analyzed genomic sequence, morphology, receptor for KSF-1phi infection, as well its phylogenetic relationships with other vibriophages. While strains carrying mshA encoding mannose-sensitive hemagglutinin (MSHA) type IV pilus were susceptible to naturally occurring MSHA-negative an deletion mutant resistant. Furthermore,...
Soil salinity has emerged as a serious issue for food security due to global climate change. It is estimated that currently about 62 million hectares or 20 percent of the world’s irrigated land affected by salinity. Salinity problem in coastal areas Bangladesh. Isolation salt-tolerant plant growth-promoting bacteria (PGPB) and applying them bioinoculants crop plants are considered promising effective biotechnological approaches combat soil This study aimed screen PGPB from root, leaf,...
The neural crest is a multipotent population of migratory cells that arises in the central nervous system and subsequently migrates along defined stereotypic pathways. In present work, we analyzed role repulsive axon guidance protein, draxin, migration cells. Draxin expressed roof plate chick trunk spinal cord around early pathway modulates cell vitro by reducing polarization these When exposed to velocity migrating was reduced, changed direction so frequently net distance also reduced....
Generation of the appropriate types, numbers and distribution neurons during development nervous system requires careful coordination proliferation, differentiation, patterning. In this work, we analyzed roles a repulsive axon guidance protein, draxin, on chick spinal cord dI3 interneuron. draxin mRNA and/or protein were detected in roof plate at first then boundary region between ventricular mantle zones dorsal basement membrane cord. Overexpression caused decreased delayed migration...
Prevalence of toxigenic Vibrio cholerae O1 in aquatic reservoirs Bangladesh apparently increases coinciding with the occurrence seasonal cholera epidemics. In between epidemics, these bacteria persist water mostly as dormant cells, known viable but non-culturable cells (VBNC), or conditionally environmental (CVEC), that fail to grow routine culture. CVEC resuscitate active when enriched culture medium supplemented quorum sensing autoinducers CAI-1 AI-2 which are signal molecules regulate...
Background Toxigenic Vibrio cholerae resides in aquatic reservoirs of cholera-endemic areas mostly a dormant form known as conditionally viable environmental cells (CVEC) which the bacteria remain embedded an exopolysaccharide matrix, and fail to grow routine bacteriological culture. The CVEC can be resuscitated by supplementing culture media with either two autoinducers CAI-1 AI-2, are signal molecules controlling quorum sensing, regulatory network bacterial gene expression dependent on...
Abstract The emergence of Omicron (B.1.1.529), a new Variant Concern in the COVID-19 outbreak, while accompanied by ongoing Delta variant infection, has once again fueled fears infection wave and global health concern. In variant, receptor-binding domain (RBD) its spike glycoprotein is heavily mutated, feature critical for transmission rate virus interacting with hACE2. this study, we used combination conventional advanced neural network-based silico approaches to predict how these mutations...
Abstract The COVID19 pandemic caused by SARS-CoV-2 virus has severely affected most countries of the world including Bangladesh. We conducted comparative analysis publicly available whole-genome sequences 64 isolates in Bangladesh and 371 from another 27 to predict possible transmission routes genomic variations among viruses. Phylogenetic indicated that pathogen was imported multiple countries. viruses found southern district Chattogram were closely related strains Saudi Arabia whereas...
The highly pathogenic virus SARS-CoV-2 has shattered the healthcare system of world causing COVID-19 pandemic since first detected in Wuhan, China. Therefore, scrutinizing genome structure and tracing transmission gained enormous interest designing appropriate intervention strategies to control pandemic. In this report, we examined 4,622 sequences from Bangladesh found that they belonged thirty-five major PANGO lineages, while Delta alone accounted for 39%, 78% were just four primary...