A5064209716- Traditional and Medicinal Uses of Annonaceae
- Essential Oils and Antimicrobial Activity
- Antimicrobial Resistance in Staphylococcus
- Bioactive Compounds and Antitumor Agents
- Asymmetric Hydrogenation and Catalysis
- Insect and Pesticide Research
- Chemical synthesis and alkaloids
- Nanoplatforms for cancer theranostics
- Synthetic Organic Chemistry Methods
- Insect Pest Control Strategies
- Weed Control and Herbicide Applications
- Synthesis and Biological Evaluation
- Viral Infections and Immunology Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Biochemical and Molecular Research
- Antibiotic Resistance in Bacteria
- Piperaceae Chemical and Biological Studies
- Cancer Research and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Pesticide and Herbicide Environmental Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Vector-borne infectious diseases
- Trypanosoma species research and implications
- Synthesis and biological activity
- Microfluidic and Capillary Electrophoresis Applications
Universidade Estadual de Campinas (UNICAMP)
2020-2024
Universidade Federal de Alfenas
2017-2023
Natural and synthetic coumarins have been described as prototypes of new drug candidates against Chagas' disease. During a typical screening with compounds, we observed the potential nitrobenzoylcoumarin (1) trypanocidal Trypanosoma cruzi epimastigotas. Then, decided to prepare evaluate set analogues from 1 check major structural requirements for activity. The variations were conducted in six different sites on original compound best derivative (3) presented activity (IC50 28 ± 3 μM) similar...
An integrated batch and continuous flow process has been developed for the gram-scale synthesis of goniothalamin. The synthetic route hinges upon a telescoped Grignard addition followed by an acylation reaction capable delivering racemic goniothalamin precursor (16) (20.9 g prepared over 3 h), with productivity 7 g·h–1. asymmetric Brown allylation protocol was also evaluated under conditions. This approach employing (−)-Ipc2B(allyl) provided (S)-goniothalamin intermediate in 98% yield 91.5%...
Coumarins are widely distributed substances in plant species that promote phytotoxic effects, allowing them to be exploited as herbicides less harmful the environment, since many invasive have demonstrated resistance commercially available products. The derived coumarins used this study had not been tested models and their effect on plants was unknown. objective of evaluate action these bioassays with Lactuca sativa L., order select most responsive substance whose toxicity best elucidated by...
Coumarins are compounds with scientifically proven antibacterial properties, and modifications to the chemical structure known improve their effects. This information is even more relevant unbridled advances of antibiotic resistance, where Staphylococcus aureus its efflux pumps play a prominent role. The study's objective was evaluate potential synthetic coumarins different substitutions in C-3 position as possible inhibitors NorA MepA S. aureus. For this evaluation, following steps took...
A flow chemistry process for the generation and use of acylketene precursors through extrusion nitrogen gas is reported. Key to development a suitable continuous protocol balance reaction concentration against pressure in reactor. The resulting enables access intercepted scaffolds using volatile amine nucleophiles has been demonstrated on gram scale. Thermal gravimetric analysis was used guide temperature set point reactor coils variety acyl ketene precursors. simultaneous two reactive...
The problem of antibiotic resistance by bacteria threatens human health. Therefore, studies in this area seek alternatives to circumvent it. study with coumarins and eugenol has already proven that these classes compounds act against bacteria. In same aspect, exposure LED also shows a bactericidal effect. Seeking possible enhancement effect, the present work studied derived from association investigate Four were tested. For this, minimum inhibitory concentrations (MICs) modulation three...
Cancer cells rely on different mechanisms to maintain their dysregulated metabolism and high proliferation. Metabolic rewiring with an increased dependency glutamine, the most abundant amino acid in blood, is a common feature of several types cancers, including triple-negative breast cancer (TNBC). The enzyme glutaminase (GLS) converts glutamine glutamate, reaction that provides α-ketoglutarate for tricarboxylic/citric cycle (TCA) chromatin-modifying enzymes, thus impacting proliferation...