Quincy Nlandu
A5063478479- Renal and related cancers
- Single-cell and spatial transcriptomics
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Renal cell carcinoma treatment
- Tissue Engineering and Regenerative Medicine
- Pluripotent Stem Cells Research
- COVID-19 and healthcare impacts
Netherlands School of Public Administration
2024
Radboud University Nijmegen
2021-2022
Radboud University Medical Center
2021-2022
Radboud Institute for Molecular Life Sciences
2021-2022
Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether this a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney cells associated with increased tubule-interstitial fibrosis in patient autopsy samples. To study effects virus on independent systemic infected human-induced pluripotent stem-cell-derived organoids SARS-CoV-2. Single-cell RNA sequencing indicated injury dedifferentiation activation profibrotic signaling...
Nephrotic syndrome (NS) is characterized by severe proteinuria as a consequence of kidney glomerular injury due to podocyte damage. In vitro models mimicking in vivo characteristics are prerequisite resolve NS pathogenesis. The detailed characterization organoid podocytes resulting from hybrid culture protocol showed population that resembles adult and was superior compared with 2D counterparts, based on single-cell RNA sequencing, super-resolution imaging electron microscopy. this study,...
Kidney organoids are an innovative tool in transplantation research. The aim of the present study was to investigate whether kidney susceptible for allo-immune attack and they can be used as a model allo-immunity transplantation. Human induced pluripotent stem cell-derived were co-cultured with human peripheral blood mononuclear cells (PBMC), which resulted invasion allogeneic T-cells around nephron structures macrophages stromal cell compartment organoids. This process associated induction...
Abstract Nephrotic syndrome (NS) is characterized by severe proteinuria as a consequence of kidney glomerular injury due to podocyte damage. In vitro models mimicking in vivo characteristics are prerequisite resolve NS pathogenesis. Here, we report human induced pluripotent stem cell derived organoids containing population that heads towards adult podocytes and were superior compared 2D counterparts, based on scRNA sequencing, super-resolution imaging electron microscopy. this study, these...