A5076784715- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Gut microbiota and health
- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
- Myasthenia Gravis and Thymoma
- Gastroesophageal reflux and treatments
- Porphyrin Metabolism and Disorders
- Molecular Sensors and Ion Detection
- Appendicitis Diagnosis and Management
- Chemical Reactions and Isotopes
- Psychoanalysis and Psychopathology Research
- PI3K/AKT/mTOR signaling in cancer
- Sexual function and dysfunction studies
- Hemodynamic Monitoring and Therapy
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Psychotherapy Techniques and Applications
- Intraperitoneal and Appendiceal Malignancies
- Analytical Chemistry and Chromatography
- Immune cells in cancer
- Reliability and Agreement in Measurement
- Helicobacter pylori-related gastroenterology studies
- Bladder and Urothelial Cancer Treatments
- Immunotherapy and Immune Responses
The University of Tokyo
2024
Asahi General Hospital
2023
Keio University
1997-2021
Sendai Kousei Hospital
2012
Social Insurance Yokohama Central Hospital
2008
Kyoto University
1998
Tokyo National Hospital
1998
A strong association between inactive aldehyde dehydrogenase-2 (ALDH2) and risk of esophageal cancer has been demonstrated in East Asian drinkers. An alcohol flushing questionnaire asking about past current tendency for facial to occur after drinking a glass (≈180 mL) beer predicts the presence ALDH2 among Japanese aged 40 years or older with sensitivity specificity approximately 90%. We invented health-risk appraisal (HRA) model that makes it possible identify men who are at high based on...
Endotoxin is postulated to be an important aggravating factor for alcoholic liver disease. We have previously reported that rats fed ethanol are more vulnerable endotoxin‐induced damage, and hepatic microcirculatory disturbance plays role this damage by observation with intravital microscopy. In study, we investigated the of adhesion molecules in chronic ethanol‐fed rats. Male Wistar were pair‐fed liquid diet (ethanol group) or isocaloric control (control 6 weeks. Leukocyte adherence...
Abstract Centenarians, or individuals who have lived more than a century, represent the ultimate model of successful longevity associated with decreased susceptibility to ageing-associated illness and chronic inflammation. The gut microbiota is considered be critical determinant human health longevity. Here we show that centenarians (average 107 yo) distinct microbiome enriched in microbes capable generating unique secondary bile acids, including iso-, 3-oxo-, isoallo-lithocholic acid (LCA),...
Abstract Objective To establish an automatic method to quantify thymic involution and hyperplasia based on plain chest computed tomography (CT). Methods We defined the region for quantification (TRQ) as target region. manually segmented TRQ in 135 CT studies, followed by construction of segmentation neural network (NN) models data. developed estimator volume (ETV), a measure tissue TRQ. The Hounsfield unit (HU) value were measured, ETV was calculated each study from 853 healthy subjects....
症例は 55 歳，男性．主訴は右下腹部痛および発熱． 2007 年 11 月某日より右下腹部痛が出現，3 日後より症状の増悪および発熱が認められたため当院を受診した．既往歴は 45 歳時に急性虫垂炎 (保存的加療で軽快)．来院時，体温 37.7°C， Mc Burney 圧痛点を中心に Blumberg 徴候と筋性防御を認めた．腹部 CT 検査で腫大した虫垂と周囲脂肪織の濃度上昇を認めたため，急性虫垂炎の診断で虫垂切除術を施行した．病理組織学的に虫垂中央部に仮性憩室が存在し，同部位に穿孔を認めた．術後経過は良好で合併症なく退院となった．虫垂憩室症は解剖学的特徴から炎症をきたすと膿瘍形成や穿孔を生じやすく，穿孔率も高いため，早期にドレナージを考慮した虫垂切除を施行する必要がある．