A5050223003- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Berberine and alkaloids research
- Sirtuins and Resveratrol in Medicine
- Lanthanide and Transition Metal Complexes
- Traditional and Medicinal Uses of Annonaceae
- Advanced MRI Techniques and Applications
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Spectroscopy Techniques in Biomedical and Chemical Research
- MRI in cancer diagnosis
- Barrier Structure and Function Studies
- Tea Polyphenols and Effects
- Plant chemical constituents analysis
- Cancer, Hypoxia, and Metabolism
- Chronic Lymphocytic Leukemia Research
- Genomics, phytochemicals, and oxidative stress
- Digital Imaging for Blood Diseases
- Seaweed-derived Bioactive Compounds
- Phytochemistry and biological activities of Ficus species
- Cholinesterase and Neurodegenerative Diseases
- RNA modifications and cancer
- Invertebrate Immune Response Mechanisms
- Amyotrophic Lateral Sclerosis Research
- Fungal Plant Pathogen Control
University of Turku
2025
Medical University of Lublin
2018-2025
Methodist Hospital
2023-2024
Houston Methodist
2023-2024
Weatherford College
2022
Molecular Oncology (United States)
2022
National Academy of Medicine
2022
Wojskowy Instytut Medycyny Lotniczej
2022
Sirtuin 7 (SIRT7), a member of the sirtuin family NAD+-dependent deacetylases, plays vital role in cancer, exhibiting context-dependent functions across various malignancies. Our study investigates SIRT7 depletion head and neck squamous cell carcinoma (HNSCC) progression. In vitro 3D organotypic models demonstrated that knock-out attenuates cancer viability, proliferation, motility as well induces downregulation migration- epithelial-mesenchymal transition (EMT)-related gene expression....
Magnoflorine (MGN) is a quaternary aporphine alkaloid that exhibits numerous therapeutic properties, including neuropsychopharmacological, anti-anxiety, immunomodulatory, anti-inflammatory, antioxidant, or antifungal activities. The aim of the present study was an investigation influence MGN on viability, proliferation, induction apoptosis, and cell cycle arrest in NCI-H1299 lung, MDA-MB-468 breast, T98G glioma, TE671 rhabdomyosarcoma cancer cells. isolated from roots Berberis cretica L. by...
Magnoflorine is an aporphine alkaloid present in plant species belonging to the Berberidaceae, Magnoliaceae, Menispermaceae, or Papaveraceae botanical families. The interest of magnoflorine has increased recently due its multiplicity pharmacological properties. aim this study was analysis combined anti-proliferative effect and cisplatin assessment drug–drug interaction between these agents using isobolographic method MDA-MB-468 human breast, NCIH1299 lung, TE671 rhabdomyosarcoma, T98G...
The aim of this study was to investigate the influence Notch1 activity level on pharmacological interaction between cisplatin (CDDP) and two histone deacetylase inhibitors (HDIs)-valproic acid (VPA) vorinostat (SAHA) in triple negative breast cancer (TNBC) cells. Stable (BC) cell lines with increased decreased were generated using a transfection method. type CDDP HDIs determined by isobolographic analysis proliferation MDA-MB-231 cells differential levels vitro. combination CDDP/SAHA...
Histone deacetylase inhibitors (HDIs) are a group of compounds that exhibit anticancer activity, but their significance and usefulness in breast cancer (BC) treatment still controversial. The ability cells to invade migrate is augmented by the acquisition mesenchymal phenotype - process known as epithelial-to-mesenchymal transition (EMT). Changes expression level different cadherins, so-called cadherin switches, have been used monitor EMT development tumor progression, particular migration...
Osthole is a simple coumarin that has been found to have anticancer, anti-inflammatory, antiviral, anticoagulant, anticonvulsant and antiallergic activities. The aim of this study was analyze the combined anti-proliferative effect cisplatin (CDDP) osthole on rhabdomyosarcoma cell line, assess pharmacology drug-drug interaction between these drugs using isobolographic analysis.The anticancer actions in combination with CDDP were evaluated tetrazolium dye-based MTT proliferation assay.Osthole...
Breast cancer (BC) is the leading cause of death in women all over world. Currently, combined chemotherapy with two or more agents considered a promising anti-cancer tool to achieve better therapeutic response and reduce therapy-related side effects. In our study, we demonstrated an antagonistic effect cytostatic agent-cisplatin (CDDP) histone deacetylase inhibitor: cambinol (CAM) for breast cell lines different phenotypes: estrogen receptor positive (MCF7, T47D) triple negative (MDA-MB-231,...
Histone deacetylase inhibitors (HDIs) are promising anti-cancer agents that inhibit proliferation of many types cancer cells including breast carcinoma (BC) cells. In the present study, we investigated influence Notch1 activity level on pharmacological interaction between cisplatin (CDDP) and two HDIs, valproic acid (VPA) suberoylanilide hydroxamic (SAHA, vorinostat), in luminal-like BC The type drug–drug CDDP HDIs was determined by isobolographic analysis. MCF7 were genetically modified to...
The sirtuin family comprises seven NAD+-dependent histone deacetylases named SIRT1 to SIRT7. least investigated SIRT7 is currently considered as a promising therapeutic target for cardiovascular diseases, diabetes and different types of cancer. So far, its structure was not experimentally resolved, except fragment N-terminus. aim this study create in silico model containing core together with N-terminus, which known affect the enzyme's catalytic activity find pockets that could be targeted...
Abstract Circulating endothelial cell progenitors originating from the bone marrow are considered to be a powerful tool in repair of endothelium damage. Due their unique properties, now broadly investigated assess clinical significance diseases e.g., associated with brain dysfunction. However, distinction terms expression specific markers remains ambiguous. Additionally, progenitor cells may change repertoire depending on microenvironment tissue which they currently located. Here, we applied...
The failures of anti-β-amyloid immunotherapies suggested that the very low fraction injected antibodies reaching brain parenchyma due to filtering effect BBB may be a reason for lack therapeutic effect. However, there is no treatment, as yet, amyotrophic lateral sclerosis (ALS) despite substantial evidence existing involvement TDP-43 protein in evolution ALS. To circumvent this effect, we have developed novel approach facilitate penetration antibody fragments (Fabs) into parenchyma....
<title>Abstract</title> Sirtuin 7 (SIRT7), a member of the sirtuin family NAD+-dependent deacetylases, plays vital role in cancer, exhibiting context-dependent functions across various malignancies. Our study investigates SIRT7 depletion head and neck squamous cell carcinoma (HNSCC) progression. <italic>In vitro</italic> 3D organotypic models demonstrated that knock-out attenuates cancer viability, proliferation, motility as well induces downregulation migration- epithelial-mesenchymal...