A5042322926- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Myofascial pain diagnosis and treatment
- Hops Chemistry and Applications
- Epigenetics and DNA Methylation
- Fungal Plant Pathogen Control
- Chromatography in Natural Products
- Musculoskeletal pain and rehabilitation
- PI3K/AKT/mTOR signaling in cancer
- Plant chemical constituents analysis
- Berberine and alkaloids research
- Natural product bioactivities and synthesis
- Uterine Myomas and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Bioactive Compounds and Antitumor Agents
- Infant Development and Preterm Care
- Seaweed-derived Bioactive Compounds
- Synthesis of Organic Compounds
- Humic Substances and Bio-Organic Studies
- Phytochemical Studies and Bioactivities
- Spine and Intervertebral Disc Pathology
- Cholinesterase and Neurodegenerative Diseases
- Genomics, phytochemicals, and oxidative stress
- Insect Utilization and Effects
- Alzheimer's disease research and treatments
Medical University of Lublin
2009-2023
Uniwersytecki Szpital Dziecięcy
2020
University of Wrocław
2006
Histone deacetylase inhibitors (HDIs) are promising anticancer drugs, which inhibit proliferation of a wide variety cancer cells including breast carcinoma cells. In the present study, we investigated influence valproic acid (VPA) and suberoylanilide hydroxamic (SAHA, vorinostat), alone or in combination with cisplatin (CDDP) on proliferation, induction apoptosis cell cycle progression MCF7, T47D MDA-MB-231 human lines. The type interaction between HDIs CDDP was determined by an...
Objective: Laryngeal squamous cell carcinoma is one of the most common malignant tumors in head and neck region. Due to poor response chemotherapeutics patients low survival rate, successful treatment larynx cancer still remains a challenge. Therefore, identification novel options needed. We investigated anticancer effects suberoylanilide hydroxamic acid (SAHA), histone deacetylase inhibitor, on two different laryngeal lines RK33 RK45. also studied antiproliferative action SAHA combination...
Magnoflorine (MGN) is a quaternary aporphine alkaloid that exhibits numerous therapeutic properties, including neuropsychopharmacological, anti-anxiety, immunomodulatory, anti-inflammatory, antioxidant, or antifungal activities. The aim of the present study was an investigation influence MGN on viability, proliferation, induction apoptosis, and cell cycle arrest in NCI-H1299 lung, MDA-MB-468 breast, T98G glioma, TE671 rhabdomyosarcoma cancer cells. isolated from roots Berberis cretica L. by...
It is known that earthworm coelomic fluid ( CF ) can affect not only cancer but also normal cells. The study demonstrated the of Dendrobaena veneta exhibited cytotoxicity against A549 lung cells did toward bronchial epithelial cell line BEAS ‐2B. selective effect on tumor was achieved after a short‐term heat pre‐treatment at 70 °C. cytotoxic time‐ and concentration‐dependent. noticeably decreased viability affected morphology Scanning electron microscopy revealed different degree destruction...
Naturally occurring coumarins are bioactive compounds widely used in Asian traditional medicine. They have been shown to inhibit proliferation, induce apoptosis, and/or enhance the cytotoxicity of currently drugs against a variety cancer cell types. The aim our study was examine antiproliferative activity different linear furanocoumarins on human rhabdomyosarcoma, lung, and larynx lines, dissolve their cellular mechanism action. were isolated from fruits Angelica archangelica L. or Pastinaca...
The vertical orientation of the body in upright standing position is maintained by keeping body's centre gravity (COG) upright, above base support, a dynamic interplay visual, vestibular, and somatosensory control systems. objectives this study were: to compare postural strategy between people with without low back pain (LBP), estimate influence stretching therapy on strategy, discover relationship restriction spine mobility occurrence some ergonomic factors.The consisted 32 patients LBP 25...
Background/Aim: Glioma is the most malignant tumour of human brain still lacking effective treatment modalities. Betulin, a pentacyclic triterpene abundantly found in birch bark, has been shown to demonstrate interesting anti-cancer activity towards many cancer cells. We determined effects acetylenic synthetic betulin derivatives (ASBDs) as anti-tumour agents on glioma cells vitro. Materials and Methods: T98G C6 cell viability proliferation were by MTT...
Background: Uterine sarcomas and carcinosarcoma are associated with unfavorable prognosis. The regimens that used in chemotherapy high incidence of side effects usually do not significantly increase patients’ survival rates. In this study we investigated the activity interactions between gemcitabine fucoidan, natural compound known for its anti-tumor properties, human cell models. Methods: SK-UT-1, SK-UT1-B (carcinosarcoma), MES-SA (leiomyosarcoma), ESS-1 (endometrial stromal sarcoma) lines...
Introduction: mTOR inhibitors are anticancer agents affecting mTOR/AKT/PI3K pathway that is one of the most important in human cancer cells.Hyperactivation and overexpression this members frequently reported uterine sarcoma carcinosarcoma.Present study aimed to assess activity two (rapamycin -RAP sapanisertib -MLN) as a single agent combined with gemcitabine (GEM, substances commonly used systemic treatment) carcinosarcoma vitro models.Material methods: SK-UT-1 SK-UT1-B (uterine...
Breast cancer (BC) is the leading cause of death in women all over world. Currently, combined chemotherapy with two or more agents considered a promising anti-cancer tool to achieve better therapeutic response and reduce therapy-related side effects. In our study, we demonstrated an antagonistic effect cytostatic agent-cisplatin (CDDP) histone deacetylase inhibitor: cambinol (CAM) for breast cell lines different phenotypes: estrogen receptor positive (MCF7, T47D) triple negative (MDA-MB-231,...
Gastric cancer is the most common and remains leading cause of death worldwide. In this study, anticancer action magnoflorine isolated via counter-current chromatography from methanolic extract Berberis vulgaris root against gastric in models primary ACC-201 AGS metastatic MKN-74 NCI-N87 cell lines was analyzed. Cell viability proliferation were tested through use MTT BrdU tests, respectively. cycle progression apoptosis evaluated using flow cytometry. The interaction docetaxel has been...
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Neuroblastoma (NB) and rhabdomyosarcoma (RMS), the most common pediatric extracranial solid tumors, still represent an important clinical challenge since no effective treatment is available for metastatic recurrent disease. Hence, there urgent need development of new chemotherapeutics to improve outcome patients. Betulin (Bet), a triterpenoid from bark birches, demonstrated interesting anti-cancer potential. The modification natural phytochemicals with evidenced anti-tumor activity,...