A5006925208- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Neonatal Respiratory Health Research
- Reconstructive Surgery and Microvascular Techniques
- Cancer Cells and Metastasis
- Peroxisome Proliferator-Activated Receptors
- Renal and related cancers
- Venous Thromboembolism Diagnosis and Management
- Wound Healing and Treatments
- Cancer, Hypoxia, and Metabolism
- Nail Diseases and Treatments
- Immunotherapy and Immune Responses
- Lipid metabolism and biosynthesis
- Plant Molecular Biology Research
- Plant nutrient uptake and metabolism
- Cancer Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Spine and Intervertebral Disc Pathology
- Management of metastatic bone disease
- Muscle metabolism and nutrition
- Facial Trauma and Fracture Management
- Periodontal Regeneration and Treatments
- Advanced Data Storage Technologies
- Nerve Injury and Rehabilitation
- Ocular Oncology and Treatments
Sam Higginbottom Institute of Agriculture
2024
Institute of Post Graduate Medical Education and Research
2015-2023
Calcutta National Medical College and Hospital
2019
Kolkata Municipal Corporation
2019
Aravind Eye Hospital
2018
Novartis (Switzerland)
2015-2017
Novartis Institutes for BioMedical Research
2017
Medical University of Graz
2009-2015
Medical College and Hospital, Kolkata
2013
Jackson Memorial Hospital
1992-2011
Ablation of a gene controlling fat breakdown can protect mice from cancer-associated uncontrolled loss and muscle. 10.1126/science.1198973
Micro RNAs (miRNAs) play an important role during renal development and show a tissue-specific enrichment in the kidney. Nephroblastomas, embryonal neoplasms of childhood, are considered to develop from nephrogenic rests (NRs) resemble morphologically genetically developing We therefore investigated kidney-enriched miRNAs pathogenesis nephroblastomas. miR-192, miR-215 miR-194 had significantly lower expression nephroblastomas regardless subtype compared with mature kidney measured by...
Hepatic inflammation is a key feature of progressive liver disease. Alterations fatty acid (FA) metabolism and signaling may play an important role in the pathogenesis nonalcoholic disease (NAFLD) its progression to steatohepatitis (NASH). Moreover, FAs activate peroxisome proliferator-activated receptor α (PPARα) as transcriptional regulator hepatic FA inflammation. Since adipose triglyceride lipase (ATGL/PNPLA2) enzyme for intracellular hydrolysis stored triglycerides determines through...
According to the concept of lipotoxicity, ectopic accumulation lipids in non-adipose tissue induces pathological changes. The most prominent effects are seen fatty liver disease, lipid cardiomyopathy, non-insulin-dependent diabetes mellitus, insulin resistance and skeletal muscle myopathy. We used MCK(m)-hLPL mouse distinguished by cardiac muscle-specific human lipoprotein lipase (hLPL) overexpression investigate overload muscle. were intrigued find that induced proteasomal activity,...
ATP citrate lyase (ACL) plays a key role in regulating mitochondrial function, as well glucose and lipid metabolism skeletal muscle. We report here that ACL silencing impairs myoblast satellite cell (SC) differentiation, it is accompanied by decrease fast myosin heavy chain isoforms MYOD. Conversely, overexpression of enhances MYOD levels promotes myogenesis. Myogenesis dependent on transcriptional but also other mechanisms. show regulates the net amount acetyl groups available, leading to...
Cancer is often associated with cachexia, cardiovascular symptoms and autonomic dysregulation. We tested whether extracardiac cancer directly affects the innervation of left ventricular myocardium. Mice injected Lewis lung carcinoma cells (tumor group, TG) or PBS (control CG) were analyzed after 21 days. Cardiac function (echocardiography), serum levels TNF-α Il-6 (ELISA), structural alterations cardiomyocytes their (design-based stereology) innervation-related mRNA (quantitative RT-PCR)...
A patient with Sturge-Weber-Dimitri disease presented intractable seizures and progressive intellectual deterioration. There was no facial nevus or focal neurologic abnormality. CT disclosed bilateral calcification in a parieto-occipital gyral pattern. Histopathology of the brain revealed extensive vessel wall cortices.
Obesity is associated with an increased risk for malignant lymphoma development. We used Bcr/Abl transformed B cells to determine the impact of aggressive formation on systemic lipid mobilization and turnover. In wild-type mice, tumor size significantly correlated depletion white adipose tissues (WAT), resulting in serum free fatty acid (FFA) concentrations which promote B-cell proliferation vitro. Moreover, development induced hepatic accumulation due enhanced (FA) uptake impaired FA...
Lipolysis is the biochemical pathway responsible for catabolism of cellular triacylglycerol (TG). Lipolytic TG breakdown a central metabolic process leading to generation free fatty acids (FA) and glycerol, thereby regulating lipid, as well energy homeostasis. The precise tuning lipolysis imperative prevent lipotoxicity, obesity, diabetes other related disorders. Here, we present our finding that miR-124a attenuates RNA protein expression major hydrolase, adipose triglyceride lipase...
Summary In previous experiments, we observed signs of cardiac failure in mice overexpressing lipoprotein lipase (LPL) under the control a muscle specific promotor and peroxisome proliferators activated receptor alpha (PPARα) knockout LPL same promotor. our current investigations, focussed on morphological consequences changes mRNA protein expression hearts from these animals. was analysed by differential display analysis Northern blot as well cDNA microarray followed pathway analysis....
Between 1971 and 1977, 40 patients with orbital hypertelorism were operated on by the craniofacial team in Toronto. Results have improved as a result of this experience. Tomography two planes has revealed four types medial wall deformity. Cephalographs proved inadequate to understand three-dimensional problem. Mobilization orbits their correct realignment, removal precise amount interorbital bone, are only preliminary steps producing good results. Different techniques for reattachment...
The viability of the rabbit epigastric flap was investigated after a period cold ischemia 3, 4, or 5 days. Groups flaps were either perfused with Ross's solution before (early perfusion), (late not at all (control). Significantly more necrosis formed exploration 7 days revascularization in early perfusion group than control (p < 0.01). Late significantly detrimental to survival as compared storage alone (0.1 p 0.5). It is concluded that ultimate fate ischemic flap, whereas late offers no...
The biocompatibility of silicone is once again the focus increased interest. Long considered inert, has now been reported to be responsible for macrophage inhibition in rats and possibly cause adjuvant disease humans, related compound silica elicited an antibody response mice. present study evaluates lymphocytic as expressed by demonstration immunologic memory, or changes specific lymphocyte subpopulations. Thirty-six female Lewis (250 gm body weight) were used test animals. Group 1 (n = 12)...
The transcription factor HOXB4 not only plays a role during nephrogenesis, but displays also oncogenic characteristics in different malignant neoplasms. An in‐silico analysis revealed as new target of microRNA‐23a (miR‐23a). Nephroblastomas are embryonal renal neoplasms childhood resembling developing kidney morphologically and genetically. In our study we verified miR‐23a furthermore examined the expression nephroblastomas. We investigated binding to 3'UTR by luciferase assay. Effects on...
We have reported a case of severe frostbite due to direct exposure liquid Freon gas (monochlorodifluoromethane), fluorinated hydrocarbon widely used as refrigerants, propellants, and industrial solvents. The patient was treated for third- fourth-degree the hand. severity injury apparently result through-and-through from (boiling point -40.5 degrees C) possible systemic vasoconstrictive effect on arterial smooth muscle inhalation gas.
Summary A new model of microvascular thrombosis is presented, with the evaluation single-dose heparin in prevention thrombosis. The technique, which involves arterial crushing and an arteriotomy intimal abrasion, was performed on superficial femoral artery rat. applied to a series 30 consecutive rat arteries. 100 percent rate seen immediately at 24 hours 10 nonheparinized animals. An operator control group vessels without abrasion had patency hours. Ten following were all patent initially, 7...