A5049599727- Digital Holography and Microscopy
- Pancreatic and Hepatic Oncology Research
- Hearing Loss and Rehabilitation
- Advanced Fluorescence Microscopy Techniques
- Epigenetics and DNA Methylation
- Renal and related cancers
Universitätsmedizin Göttingen
2021
The cochlea of our auditory system is an intricate structure deeply embedded in the temporal bone. Compared with other sensory organs such as eye, has remained poorly accessible for investigation, example, by imaging. This limitation also concerns further development technology restoring hearing case cochlear dysfunction, which requires quantitative information on spatial dimensions and sensorineural status cochlea. Here, we employed X-ray phase-contrast tomography light-sheet fluorescence...
To improve the treatment of pancreatic ductal adenocarcinoma (PDAC), a promising strategy consists personalized chemotherapy based on gene expression profiles. Investigating panel PDAC-derived human cell lines, we found that their sensitivities towards cisplatin fall in two distinct classes. The platinum-sensitive class is characterized by GATA6, miRNA-200a, and miRNA-200b, which might be developable as predictive biomarkers. In case resistant PDAC cells, identified synergism with HSP90...