A5084653086- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Digital Holography and Microscopy
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Fluorescence Microscopy Techniques
- Advanced X-ray Imaging Techniques
- Advanced Electron Microscopy Techniques and Applications
- Hearing Loss and Rehabilitation
Universitätsmedizin Göttingen
2020-2025
University of Göttingen
2025
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
2020
Multi-scale X-ray phase contrast tomography (XPCT) enables three-dimensional (3D), non-destructive imaging of intact small animal cochlea and apical cochlear turns. Here we report on post-mortem excised non-human primate rodent cochleae at different [Formula: see text]-CT nano-CT synchrotron instruments. We explore sample embeddings, stainings regimes. Under optimized conditions preparation, instrumentation, protocol, retrieval, high image quality detail level can be achieved in 3D...
The cochlea of our auditory system is an intricate structure deeply embedded in the temporal bone. Compared with other sensory organs such as eye, has remained poorly accessible for investigation, example, by imaging. This limitation also concerns further development technology restoring hearing case cochlear dysfunction, which requires quantitative information on spatial dimensions and sensorineural status cochlea. Here, we employed X-ray phase-contrast tomography light-sheet fluorescence...
Altersbedingter Hörverlust ist die häufigste Form der Schallempfindungsschwerhörigkeit. Studien letzten Jahre an Nagetieren zeigen, dass altersbedingter hauptsächlich mit Synaptopathie von Bandsynapsen, dem Verlust inneren und äußeren Haarzellen (IHC, OHC) Spiralganglionneuronen (SGN) zusammenhängt.
Age-related hearing loss is the most common form of sensorineural loss. Studies from last years in rodents show that age-related mainly associated with synaptopathy ribbon synapses, inner and outer hair cells (IHC, OHC) spiral ganglion neurons (SGN).
Altersbedingte Schwerhörigkeit ist die häufigste Form der Schallempfindungsschwerhörigkeit nach heutigem Forschungsstand hauptsächlich mit Synaptopathie von Bandsynapsen, dem Verlust inneren und äußeren Haarzellen (IHZ, OHZ) Spiralganglionneuronen (SGN) zusammenhängt.
Age-related hearing loss is the most common form of sensorineural loss. Studies from last years in rodents show that age-related mainly associated with synaptopathy ribbon synapses, inner and outer hair cells (IHC, OHC) spiral ganglion neurons (SGN).