A5089549553- Multiple Sclerosis Research Studies
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Cerebrospinal fluid and hydrocephalus
- Extracellular vesicles in disease
- Spinal Dysraphism and Malformations
- Retinal and Optic Conditions
- Telemedicine and Telehealth Implementation
- Traumatic Brain Injury and Neurovascular Disturbances
- Functional Brain Connectivity Studies
- Glaucoma and retinal disorders
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Intensive Care Unit Cognitive Disorders
- Genetic Syndromes and Imprinting
- COVID-19 and Mental Health
- Fetal and Pediatric Neurological Disorders
- Genetics and Neurodevelopmental Disorders
- Epilepsy research and treatment
- Parathyroid Disorders and Treatments
- Amyotrophic Lateral Sclerosis Research
- Neurobiology of Language and Bilingualism
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2017-2024
Cambridge University Hospitals NHS Foundation Trust
2024
University of Cambridge
2024
University of Milan
2017-2023
Ospedale Maggiore
2022-2023
Ferrari (Italy)
2019-2022
Brighton and Sussex Medical School
2021
University of Sussex
2021
University of Florence
2017
San Raffaele University of Rome
2015-2017
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has dramatically stressed the health care system and provoked changes in population use of digital technologies. Digital divide is any uneven distribution Information Communications Technologies between people. Aims purpose this work was to describe a patients with dementia contacted by telemedicine during Italian lockdown for COVID-19 pandemic. Method One hundred eight cognitive impairment were video call perform...
Abstract Aquaporin-4 (AQP4) is a channel protein that plays fundamental role in glymphatic system, newly described pathway for fluid exchange the central nervous as well figure fascinating new theory pathophysiology of neurodegenerative diseases such Alzheimer’s disease (AD) and frontotemporal dementia (FTD). In this study, cerebrospinal (CSF) concentration AQP4, amyloid-β, total tau P-tau were determined 103 CSF samples from patients affected by dementias (AD FTD) or psychiatric 21...
Background: The importance of neurodegeneration in multiple sclerosis (MS) is increasingly well recognized. Objectives: To evaluate retinal pathology using optical coherence tomography (OCT) and to investigate possible associations between layers’ thickness specific patterns gray matter volume patients with a new diagnosis MS. Methods: A total 31 underwent OCT scans brain magnetic resonance imaging. In total, 30 controls the same procedure. association focal cortical measurements was...
In multiple sclerosis (MS), monoaminergic systems are altered as a result of both inflammation-dependent reduced synthesis and direct structural damage. Aberrant neurotransmission is increasingly considered major contributor to fatigue pathophysiology. this study, we aimed compare the integrity white matter fibre tracts projecting from brainstem nuclei in group patients with MS (n = 68) healthy controls 34), investigate its association fatigue. Fibre was assessed novel fixel-based analysis...
Abstract Fatigue is a highly prevalent and debilitating symptom in multiple sclerosis, but currently the available treatment options have limited efficacy. The development of innovative efficacious targeted treatments for fatigue sclerosis has been marred by knowledge underlying mechanisms. One hypotheses postulates that pathology might cause reduced monoaminergic release central nervous system with consequences on motivation, mood attention. Here, we applied recently developed...
Objective To assess the connection between amyloid pathology and white matter (WM) macrostructural microstructural damage in demented patients compared with controls. Methods Eighty-five participants were recruited: 65 newly diagnosed Alzheimer’s disease (AD), non-AD dementia or mild cognitive impairment 20 age-matched sex-matched healthy β-amyloid 1-42 (Aβ) levels determined cerebrospinal fluid (CSF) samples from all five Among patients, 42 had pathological CSF Aβ (Aβ(+)), while 23 normal...
Background: Long non-coding RNAs (lncRNAs) play crucial roles in gene regulation and are implicated neurodegenerative diseases, including frontotemporal dementia (FTD). However, their expression patterns potential as biomarkers genetic FTD involving Chromosome 9 Open Reading Frame (C9ORF72), Microtubule Associated Protein Tau (MAPT), Progranulin (GRN) genes not well understood. Objective: This study aimed to profile the levels of lncRNAs peripheral blood mononuclear cells collected within...
Abstract Background According to the 2018 NIA-AA research framework, Alzheimer’s disease (AD) is not defined by clinical consequences of disease, but its underlying pathology, measured biomarkers. Evidence both amyloid-β (Aβ) and phosphorylated tau protein (p-tau) deposition—assessed interchangeably with amyloid-positron emission tomography (PET) and/or cerebrospinal fluid (CSF) analysis—is needed diagnose AD in a living person. Our aim was test new framework large cohort cognitively...
Cognitive deficits strongly affect the quality of life patients with multiple sclerosis (MS). However, no cognitive MS biomarkers are currently available. Extracellular vesicles (EVs) contain markers parental cells and able to pass from brain into blood, representing a source disease biomarkers. The aim this study was investigate whether small non-coding microRNAs (miRNAs) targeting synaptic genes packaged in plasma EVs may reflect patients. Total were precipitated by Exoquick twenty-six...
Aquaporin4 (AQP4) is a water channel protein located at astrocyte foot processes that plays role in glymphatic system, highly organized fluid transport pathway which seems to be involved Alzheimer's disease (AD) and normal pressure hydrocephalus (NPH) pathophysiology. Cerebrospinal (C SF) AQP4 levels were determined 11 patients with AD, 10 NPH, 9 controls. We found significantly reduced AD patients, trend reduction NPH correlation between amyloid-β CSF levels. This study indicates the...
Nasu-Hakola disease (NHD), also known as polycystic lipomembranous osteodysplasia and sclerosing leukoencephalopathy, is an autosomal recessive disorder characterized by dementia multifocal bone cysts. NHD associated with the loss-of-function mutation of triggering receptor expressed on myeloid cells-2 gene ( TREM2 ), leading to aberrant form TREM2.1
Background: The importance of predicting disease progression in multiple sclerosis (MS) has increasingly been recognized, and hence reliable biomarkers are needed. Objectives: To investigate the prognostic role cerebrospinal fluid (CSF) amyloid beta 1–42 (Aβ) levels by determination a cut-off value to classify patients slow fast progressors. evaluate possible association with white matter (WM) grey (GM) damage at early stages. Methods: Sixty were recruited followed up for 3–5 years. Patients...
Posterior Cortical Atrophy (PCA) is an atypical presentation of Alzheimer disease (AD) characterized by atrophy posterior brain regions. This pattern usually evaluated with Koedam visual rating scale, a score developed to enable assessment parietal on magnetic resonance imaging (MRI). However, scale complex assess and its utility in the differential diagnosis between PCA typical AD has not been demonstrated yet. The aim this study therefore spot simple reliable MRI element able differentiate...
Abstract Purpose Positron emission tomography (PET) with amyloid tracers (amy-PET) allows the quantification of pathological deposition in brain tissues, including white matter (WM). Here, we evaluate amy-PET uptake WM lesions (WML) and normal-appearing (NAWM) patients Alzheimer’s disease (AD) non-AD type dementia. Methods Thirty-three cognitively impaired subjects underwent magnetic resonance imaging (MRI), Aβ 1-42 (Aβ) determination cerebrospinal fluid (CSF) amy-PET. Twenty-three...
Background Perivascular spaces (PVS) are fluid-filled compartments that dilate in response to many different conditions. A high burden of enlarged PVS (EPVS) the centrum semiovale (CSO) has been linked neurodegeneration. Moreover, an increase cerebrospinal fluid (CSF) levels aquaporin-4 (AQP4), a water channel expressed on PVS-bounding astrocytes, described patients with neurodegenerative dementia. Our aim was investigate relationship between diseases and two putative glymphatic system...
Abstract Introduction Differential diagnosis among subjects with Primary Progressive Aphasia (PPA) can be challenging. Structural MRI support the clinical profile. Visual rating scales are a simple and reliable tool to assess brain atrophy in setting. The aims of study were establish what extent visual could useful differential PPA, compare diagnostic impressions derived from routine interpretations those obtained using scale correlate results voxel-based morphometry (VBM) analysis. Method...
Abstract The glymphatic system (GS) is a whole‐brain perivascular network, consisting of three compartments: the periarterial and perivenous spaces interposed brain parenchyma. GS dysfunction has been implicated in neurodegenerative diseases, particularly Alzheimer's disease (AD). So far, comprehensive research on humans limited by absence easily accessible biomarkers. Recently, promising non‐invasive methods based magnetic resonance imaging (MRI) along with aquaporin‐4 (AQP4) quantification...