A5076943767- Multiple Sclerosis Research Studies
- Functional Brain Connectivity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Mental Health Research Topics
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Parkinson's Disease Mechanisms and Treatments
- Photoreceptor and optogenetics research
- Cerebral Palsy and Movement Disorders
- Dementia and Cognitive Impairment Research
- MicroRNA in disease regulation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neural dynamics and brain function
- Hearing, Cochlea, Tinnitus, Genetics
- Diversity and Impact of Dance
- Circular RNAs in diseases
- Long-Term Effects of COVID-19
- Advanced Neuroimaging Techniques and Applications
- Neurological disorders and treatments
- Autoimmune and Inflammatory Disorders Research
- Extracellular vesicles in disease
- Advanced Fluorescence Microscopy Techniques
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
Amsterdam Neuroscience
2019-2023
Amsterdam UMC Location Vrije Universiteit Amsterdam
2014-2023
Vrije Universiteit Amsterdam
2014-2023
Amsterdam University Medical Centers
2019-2023
University College London
2021
Center for Neurosciences
2019-2020
Kessler Foundation
2016
Stichting ParkinsonFonds
2014
To characterize functional network changes related to conversion cognitive impairment in a large sample of patients with multiple sclerosis (MS) over period 5 years.Two hundred twenty-seven MS and 59 healthy controls the Amsterdam cohort underwent neuropsychological testing resting-state fMRI at 2 time points (time interval 4.9 ± 0.9 years). At both baseline follow-up, were categorized as cognitively preserved (CP; n = 123), mildly impaired (MCI; z < -1.5 on ≥2 tests, 32), or (CI; -2 72),...
Background: Synaptic and neuronal loss contribute to network dysfunction disability in multiple sclerosis (MS). However, it is unknown whether excitatory or inhibitory synapses neurons are more vulnerable how their losses impact functioning. Objective: To quantify investigate synaptic affects functioning through computational modeling. Methods: Using immunofluorescent staining confocal microscopy, densities of glutamatergic GABAergic were compared between post-mortem MS non-neurological...
Cognitive impairment in people with MS (PwMS) has primarily been investigated using conventional imaging markers or fluid biomarkers of neurodegeneration separately. However, the single use these do only partially explain large heterogeneity found PwMS.To investigate multimodal (bio)markers: i.e., serum and cerebrospinal (CSF) levels neurofilament light chain (NfL) glial fibrillary acidic protein (GFAP) predicting cognitive functioning PwMS.Eighty-two PwMS (56 females, disease duration = 14...
Cognitive deficits strongly affect the quality of life patients with multiple sclerosis (MS). However, no cognitive MS biomarkers are currently available. Extracellular vesicles (EVs) contain markers parental cells and able to pass from brain into blood, representing a source disease biomarkers. The aim this study was investigate whether small non-coding microRNAs (miRNAs) targeting synaptic genes packaged in plasma EVs may reflect patients. Total were precipitated by Exoquick twenty-six...
Abstract Cognitive impairment occurs in 40–65% of persons with multiple sclerosis and may be related to alterations glutamatergic GABAergic neurotransmission. Therefore, the aim this study was determine how changes relate cognitive functioning vivo. Sixty (mean age 45.5 ± 9.6 years, 48 females, 51 relapsing-remitting sclerosis) 22 age-matched healthy controls (45.6 22.0 17 females) underwent neuropsychological testing MRI. Persons were classified as cognitively impaired when scoring at least...
Background: Suboptimal performance during neuropsychological assessment renders cognitive test results invalid. However, suboptimal has rarely been investigated in multiple sclerosis (MS). Objectives: To investigate potential underlying mechanisms of MS. Methods: Performance validity testing, assessments, neuroimaging, and questionnaires were analyzed 99 MS outpatients with complaints. Based on testing patients classified as valid or invalid performers, based cognitively impaired preserved....
Despite advances in pharmacologic management, deficits gait and gait-related activities remain persistent Parkinson disease (PD), resulting reduced safety ADL independence. Alternative rehabilitative allied health approaches to the management of these problems, such as physical therapy or exercise training, are, therefore, important. We summarize literature on neuroprotective neurorestorative effects exercise. Next, we discuss data importance training with external rhythmic cues literature,...
Background: Cognitive training elicits mild-to-moderate improvements in cognitive functioning people with multiple sclerosis (PwMS), although response heterogeneity limits overall effectiveness. Objective: To identify patient characteristics associated and non-response to training. Methods: Eighty-two PwMS were randomized into a 7-week attention ( n = 58, age 48.4 ± 10.2 years) or waiting-list control group 24, 48.5 9.4 years). Structural functional magnetic resonance imaging (MRI) was...
Background/objective: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated of a running intervention and functional connectivity pwMS. Methods/results: Memory resting-state magnetic resonance imaging (fMRI) data were collected ( n = 15) waitlist group 14). Visuospatial improvement was correlated to increased between hippocampus default-mode network (DMN) only. Conclusion: As...