A5085607799- Genomics, phytochemicals, and oxidative stress
- NF-κB Signaling Pathways
- RNA regulation and disease
- MicroRNA in disease regulation
- RNA modifications and cancer
- Orthopedic Surgery and Rehabilitation
- Cancer-related molecular mechanisms research
- Hip and Femur Fractures
- Acupuncture Treatment Research Studies
- interferon and immune responses
- Traditional Chinese Medicine Studies
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- RNA Research and Splicing
- Mast cells and histamine
- Pharmacological Effects of Natural Compounds
- Single-cell and spatial transcriptomics
- Diabetic Foot Ulcer Assessment and Management
- Bone Tumor Diagnosis and Treatments
- Influenza Virus Research Studies
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Sarcoma Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
Hubei University of Chinese Medicine
2024-2025
Southern Medical University
2014-2025
Shaoguan University
2017-2025
Guangdong Medical College
2025
Shantou University Medical College
2023
Shantou University
2023
Yue Bei People's Hospital
2023
National Institutes of Health
2022
Shaoguan Railway Hospital
2017-2022
National Institute on Deafness and Other Communication Disorders
2022
Bone metastasis is closely related to tumor death in prostate cancer (PC). Long noncoding RNA small nucleolar host gene 3 (SNHG3) has been implicated the initiation and progression of multiple human cancers. Nevertheless, biological function SNHG3 PC not elucidated. Our results indicated that was upregulated bone metastasis-positive tissues compared metastasis-negative adjacent normal tissues. High expression indicates advanced clinicopathological features predicts poor prognosis patients...
Background Respiratory tract infections (RTIs) are a heavy burden on society. However, due to the complex etiology of RTIs, clinical diagnosis, treatment, and prevention these remain challenging, especially in developing countries. Methods To determine epidemiological characteristics 18 respiratory pathogens, we analyzed 12,502 patients with acute (ARIs) by performing polymerase chain reaction (PCR) patient pharyngeal swabs. Results Samples positive for at least 1 pathogen were obtained from...
Abstract There are three subtypes of undifferentiated human conventional osteosarcoma (HCOS): osteoblastic (OOS), chondroblastic (COS), and fibroblastic (FOS). HCOS also exhibits heterogeneous pathological maldifferentiation in individual patients. Currently, the mechanism regulating differentiation remains unclear, therapies ineffective. Osteopontin (OPN) osteocalcin (OCN) markers osteoblast maturation, their expression is inhibited HCOS. A previous study found that PLK2 TAp73...
TNFα is a key mediator of immune and radiotherapy-induced cytotoxicity, but many cancers, including head neck squamous cell carcinomas (HNSCC), display TNF resistance due to activation the canonical IKK-NF-κB/RELA pro-survival pathway. However, toxicities associated with direct targeting pathway point need identify mechanism(s) contributing synthetic lethal targets overcome such in cancer cells. Here, RNAi screening for modulators TNFα-NF-κB reporter activity survival unexpectedly implicated...
Osteosarcoma(OS) remains a major health concern in childhood and adolescence, although cisplatin is one of the gold standard chemotherapeutic drugs treatment OS, chemoresistant to common. Phosphoinositide 3-kinase (PI3K)-Akt-mammalian target rapamycin inhibitor (mTOR) pathway autophagy regulates chemosensitivity incancer cells. In this study, we hypothesized that NVP-BEZ235, dual PI3K/mTOR, could synergize sensitivity OS. vitro, NVP-BEZ235 plus cisplatinexerted synergistic effect on cell...
TAp73, a member of the p53 tumor suppressor family, is frequently overexpressed in malignant tumors humans. TAp73 abundance and phosphorylation modification result variations transcriptional activity. In previous study, we found that antitumor function was reactivated by dephosphorylation head neck squamous cell carcinomas. Polo-like kinase 2 (PLK2) displayed close relationship with family affecting fate cells. Herein, investigate hypothesis PLK2 phosphorylates inhibits function.Head...
Introduction In recent decades, single-cell sequencing technology has developed rapidly and used widely in various fields of life sciences, especially for the detection immune cells. A bibliometric analysis research work on cells published during 2011-2021 period should provide new insight use sequencing. Methods We screened 1,460 publications according to publication date, article type, language, country. Reults The United States first largest number articles, while China’s started...
Osteosarcoma (OS) universally exhibits heterogeneity and cisplatin (CDDP) resistance. Although the Wee1/CDC2 nuclear factor кB (NF-κB) pathways were reported to show abnormal activation in some tumor cells with CDDP resistance, whether there is any concrete connection currently unclear. We explored it human OS cells.Multiple cell lines exposed a Wee1 inhibitor (AZD1775) assess half-maximal inhibitory concentration values. Western blot, coimmunoprecipitation, confocal immunofluorescence,...
Circular RNAs (circRNAs) are a type of non-coding generated from back splicing to enhance or inhibit the progression multiple human cancers including osteosarcoma (OS). Although circ_0102049 has been found be highly expressed in OS cell lines, role and specific mechanism remains unclear. Here, we that silence could significantly exacerbate tumorigenesis vivo through sponging microRNA-520g-3p. Polo-like kinase 2 (PLK2) was predicted target miR-520g-3p, luciferase reporter assay revealed...
The reconstruction of complex hand injury such as multifinger soft tissue defect remains a challenging problem. Two cases repair with exposed bones using the free chimeric flaps based on dorsalis pedis vessels are presented. male patients, 46 years old and 36 old, suffered from thermocompression to dorsum fingers resulting in defects multiple fingers. flap was designed applied cover defects. donor sites were covered by skin grafts. postoperative courses uneventful. Both patients followed up...
<title>Abstract</title> <bold>Purpose </bold>We aimed to explore the surgical techniques employed in robot-assisted "Four-guide pin" cannulated screw internal fixation for calcaneal fractures and evaluate its clinical efficacy compared traditional treatments. <bold>Methods </bold>Retrospective analysis was conducted on data of 57 patients with treated from January 2021 December 2023. The were divided into three groups: group A (25 patients, 26 feet) underwent open reduction (ORIF), B (18 19...
To observe the effect of electroacupuncture (EA) on central nervous inflammatory response in obese rats, so as to explore its mechanisms underlying improvement obesity.
Abstract Background: TAp73, as a member of the p53 tumor suppressor family, is frequently overexpressed in malignant tumors humans. The abundance TAp73 expression and phosphorylation modification regulate its transcriptional activity. In previous study, we found that anti-tumor function was reactivated by protein dephosphorylation. Polo-like kinase 2 (PLK2) previously phosphorylated transcriptionally regulated p53, these interactions affected fate cells. However whether PLK2 interacts with...
Objective To observe the clinical efficacy of platelet rich plasma (PRP) injection in treatment chronic meniscus injury. Methods From January 2016 to October 2017, a total 35 patients with injury, which courses were more than 6 months, treated PRP Shaoguan Hospital Affiliated Southern Medical University. Their knee joints immobilized for three weeks after first and followed up six months. Lysholm score, visual analogue pain score (VAS), rotation test (McMurray test), Stoller injury...
Supplementary Data from Inhibiting WEE1 and IKK-RELA Crosstalk Overcomes TNFα Resistance in Head Neck Cancers
Supplementary Figure from Inhibiting WEE1 and IKK-RELA Crosstalk Overcomes TNFα Resistance in Head Neck Cancers
<div>Abstract<p>TNFα is a key mediator of immune and radiotherapy-induced cytotoxicity, but many cancers, including head neck squamous cell carcinomas (HNSCC), display TNF resistance due to activation the canonical IKK–NF-κB/RELA pro-survival pathway. However, toxicities associated with direct targeting pathway point need identify mechanism(s) contributing TNFα synthetic lethal targets overcome such in cancer cells. Here, RNAi screening for modulators TNFα–NF-κB reporter activity...