A5049600260- Immune cells in cancer
- Protease and Inhibitor Mechanisms
- Vasculitis and related conditions
- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
- Peptidase Inhibition and Analysis
- COVID-19 and healthcare impacts
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Congenital Diaphragmatic Hernia Studies
- Long-Term Effects of COVID-19
- Immune Cell Function and Interaction
- Tracheal and airway disorders
- Gut microbiota and health
- Hematological disorders and diagnostics
- Mass Spectrometry Techniques and Applications
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Mast cells and histamine
- Eosinophilic Disorders and Syndromes
- Immune responses and vaccinations
- Cardiac Fibrosis and Remodeling
- HIV Research and Treatment
- Advanced Proteomics Techniques and Applications
- Pulmonary Hypertension Research and Treatments
Trinity College Dublin
2018-2024
Royal College of Surgeons in Ireland
2023-2024
St. James's Hospital
2021-2022
University College Dublin
2002-2016
Immunosuppressive treatment in patients with rheumatic diseases can maintain disease remission but also increase risk of infection. Their response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is frequently blunted. In this study we evaluated the effect immunosuppression exposure on humoral and T cell immune responses SARS-CoV-2 infection two distinct cohorts patients; one during 3 months later convalescence, another prior vaccination, follow up sampling 6 weeks...
Background: The current coronavirus disease 2019 (COVID-19) pandemic began in Ireland with the first confirmed positive case March 2020. In early stages of clinicians and researchers two affiliated Dublin hospitals identified need for a COVID-19 biobanking initiative to support enhance research into disease. Through large scale analysis clinical, regional, genetic characteristics patients, biobanks have helped identify, so protect, at risk patient groups STTAR Bioresource has been created...
Clinical and experimental data suggest that pathogenesis in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is driven by ANCA-mediated activation of neutrophils monocytes. While the role has been extensively investigated, function monocytes remains relatively understudied. We have previously demonstrated stimulation with anti-myeloperoxidase (MPO), but not anti-proteinase-3 (PR3), antibodies results production pro-inflammatory cytokine IL-1β. Changes cellular metabolism,...
Introduction Immunometabolism examines the links between immune cell function and metabolism. Dysregulation of metabolism is now an established feature innate activation. Advances in liquid chromatography mass spectrometry (LC-MS) technologies have allowed discovery unique insights into cellular metabolomics. Here we studied compared different sample preparation techniques data normalisation methods described literature when applied to metabolomic profiling human monocytes. Methods Primary...
Bronchoalveolar lavage (BAL) is essential in determining the efficacy of novel therapies alpha-1 antitrypsin deficiency (AATD). These require initial proof-of-concept demonstration that treatment administration increases (AAT) levels and/or anti-neutrophil elastase inhibitory capacity (ANEC) lung. Early-phase studies often encounter high interindividual variability BAL results, primarily stemming from inherent dilution characteristics returned fluid. A protocol minimises this needed for...
<b>Aims:</b> The aim of this study is to develop a bronchoalveolar lavage (BAL) method that represents the alveoli, rather than larger airways, and addresses variable BAL return observed in COPD alpha-1 antitrypsin deficiency (AATD). <b>Methods:</b> Patients referred through Irish Centre for Genetic Lung Disease were evaluated. This included healthy emphysematous patients with severe AATD (ZZ), mild (MZ), controls normal levels AAT (MM). 70 underwent time-matched phlebotomy BAL. A 6th 8th...
<b>Background:</b> From March 2006 to October 2010, 140 patients with alpha-1 antitrypsin (AAT) deficiency who received either intravenous AAT augmentation or placebo in the RAPID study were included an open-label extension trial (RAPID-OLE). was shown significantly slow rate of computed tomography (CT) lung density loss; no differences noted spirometry, diffusion capacity (DLCO), quality life (QoL). Patients Irish RAPID-OLE cohort continued for ensuing 12 years. <b>Aims and objectives:</b>...
interleukin [IL]-1b, IL-6 and tumor necrosis factor [TNF]-a.Correlations between various inflammatory indexes validated higher chemokines were also analyzed to explore their relations.Results: The patients healthy controls in chemokine array or ELISA assay age gender-matched respectively (Female: Male, 5:0 vs 5:0, 29.20AE9.07vs 29.6AE8.32years; Female: 16:4 16:4; 37.6AE10.72vs 34.33AE14.44years).For array, the pixel density represented corresponding level.When comparing those TA heathy...
<ns4:p>The ongoing coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome 2 (SARS-CoV-2). Current advisory guidelines for high-risk groups—including people with autoimmune taking immunosuppressive therapies—are to take increased precautions and avoid any unnecessary contacts. The aim of the DeCOmPRESS study define course immune profile COVID-19 in immunosuppressed patients. We will clinically phenotype patients ANCA-associated vasculitis (AAV) who develop...