A5085783814- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Neuroendocrine Tumor Research Advances
- Diabetes Management and Research
- Pancreatic and Hepatic Oncology Research
- Diabetes and associated disorders
- Neuroblastoma Research and Treatments
- Peroxisome Proliferator-Activated Receptors
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Diet, Metabolism, and Disease
- Natural Antidiabetic Agents Studies
- Adrenal Hormones and Disorders
- Helicobacter pylori-related gastroenterology studies
- Cardiovascular Function and Risk Factors
- Genetics and Neurodevelopmental Disorders
- Ion Channels and Receptors
- Hormonal Regulation and Hypertension
- Gastroesophageal reflux and treatments
- Endoplasmic Reticulum Stress and Disease
- Angiogenesis and VEGF in Cancer
- Hedgehog Signaling Pathway Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Gastrointestinal motility and disorders
Kansai Electric Power (Japan)
2017-2024
Kyoto University
2015-2022
Kansai Electric Power Hospital
2017-2018
Nagase ChemteX (Japan)
2018
Kitano Hospital
2012-2013
Diabetes Australia
2013
Procyanidins, the main ingredient of apple polyphenols, are known to possess antioxidative and anti-inflammatory effects associated closely with pathophysiology insulin resistance type 2 diabetes. We investigated orally administered procyanidins (APCs) on glucose metabolism using diabetic ob/ob mice. found no difference in body weight or composition between mice treated APCs untreated A 4 week oral administration containing water [0.5% (w/v)] ameliorated tolerance, resistance, hepatic...
Abstract The long-chain fatty acid receptor GPR40 plays an important role in potentiation of glucose-induced insulin secretion (GIIS) from pancreatic β-cells. Previous studies demonstrated that activation enhances Ca 2+ release the endoplasmic reticulum (ER) by activating inositol 1,4,5-triphosphate (IP3) receptors. However, it remains unknown how ER via IP3 is linked to GIIS potentiation. Recently, stromal interaction molecule (STIM) 1 was identified as a key regulator store-operated entry...
Imeglimin is a new oral anti-diabetic drug with similar structure to that of metformin; however, unlike metformin, clinical trials indicate imeglimin elicits its glucose-lowering effect mainly by enhancement insulin secretion. The comparative effects the two drugs on incretin secretion remains be elucidated.
Abstract Aims/Introduction The glucose‐lowering effects of the glucagon‐like peptide‐1 receptor agonist, liraglutide, have been shown to rely on remaining β‐cell function. However, possible associations function with liraglutide in combination basal insulin remain unknown and warrant investigation. Materials Methods This was a single‐center, retrospective, observational study carried out private hospital Osaka, Japan. Type 2 diabetes patients who received prescription change from therapy,...
Heterogeneity of gene expression and rarity replication hamper molecular analysis β-cell mass restoration in adult pancreas. Here, we show transcriptional dynamics process by single-cell RNA sequencing murine pancreas with or without partial pancreatectomy. We observed heterogeneity Ins1-expressing β-cells identified the one cluster as replicating high cell proliferation markers Pcna Mki67. also recapitulated cycle transition accompanied switching cyclins E2F transcription factors. Both...
Since infection with Helicobacter pylori has been suggested to play a pathogenic role in diabetes mellitus, we investigated whether eradication therapy for H. might affect glycemic control Japanese subjects type 2 diabetes. A total of 72 (55 males, 17 females; aged 63.7 years) who received were included. The change their blood glycosylated hemoglobin (A1C) levels 3 months before (-3 m) the eradication, as well (3 and 6 (6 after evaluated. Their A1C did not show any significant {6.9 [0.1]%...
Src, a non-receptor tyrosine kinase, regulates wide range of cellular functions, and hyperactivity Src is involved in impaired glucose metabolism pancreatic β-cells. However, the physiological role normal, unstressed β-cells remains unclear. In present study, we investigated insulin secretion metabolism.Src was downregulated using small interfering ribonucleic acid INS-1 cells, glucose-induced secretion, adenosine triphosphate content, intracellular calcium concentration, utilization...
The present study was designed to assess possible relationships between deterioration of the glycated hemoglobin (HbA1c)-lowering effects in dipeptidyl peptidase-4 inhibitor (DPP4i) monotherapy and macronutrient intake among individuals with type 2 diabetes. Type diabetes patients who began continued DPP4i without any prescription change for 1 year were retrospectively stratified into two groups: (i) maintained their HbA1c levels during 0.5- 1-year period after initiation (group A, ΔHbA1c...
Pancreatic neuroendocrine tumors (PanNET) were classified into grades (G) 1 to 3 by the World Health Organization in 2017, but precise mechanisms of PanNET initiation and progression have remained unclear. In this study, we used a genetically engineered mouse model investigate formation. Although pancreas-specific deletion Rb gene (Pdx1-Cre;Rbf/f ) mice did not affect pancreatic exocrine cells, α-cell/β-cell ratio islet cells was decreased at 8 months age. During long-term observation (18-20...
Pancreatic β-cell proliferation has been gaining much attention as a therapeutic target for the prevention and treatment of diabetes. In order to evaluate potential mitogens, accurate reliable methods detection quantification rate are indispensable. this study, we developed novel tool that specifically labels replicating β-cells mVenus+ cells by using RIP-Cre; R26Fucci2aR mice expressing fluorescent ubiquitination-based cell cycle indicator Fucci2a in β-cells. response stimuli, such insulin...
Our previous study demonstrated that sphingosine kinase 1-interacting protein (SKIP, or Sphkap) is expressed in pancreatic β-cells, and depletion of SKIP enhances glucose-stimulated insulin secretion. We find here also intestinal K- L-cells secretion gastric inhibitory polypeptide (GIP) glucagon-like peptide-1 (GLP-1) as well are significantly increased, blood glucose levels decreased SKIP-deficient (SKIP-/-) mice compared with those wild-type mice. Plasma triglyceride (Tg), LDL cholesterol,...
Abstract Tissue optical clearing permits detailed evaluation of organ three-dimensional (3-D) structure as well that individual cells by tissue staining and autofluorescence. In this study, we evaluated intestinal morphology, epithelial (IECs), enteroendocrine cells, such incretin-producing in reporter mice 3-D imaging. imaging using enabled us to evaluate both morphologies cell numbers, villus length crypt depth the same samples. disease mouse model lipopolysaccharide (LPS)-injected mice,...
Background: Imeglimin has related structure to metformin, but several studies have revealed dissimilarities of glucose-lowering mechanisms between the two drugs. Some clinical trials suggest unlike imeglimin exhibits hypoglycemic effect by enhancing insulin secretion rather than improving resistance. In addition, nothing is known regarding difference on incretin Therefore, we investigate effects and in comparison with metformin patients type 2 diabetes. Method: This was a single center,...
The clinical significance of enterococci in intra-abdominal infections, particularly those caused by multiple organisms, remains unclear. There are no definitive guidelines regarding the use empiric therapy with antimicrobial agents targeting enterococci. In this study, we evaluated impact initial administration anti-enterococcal on treatment infections patients cancer whom were isolated from ascitic fluid cultures. This retrospective study was conducted at Shizuoka Cancer Center between...
Acromegaly is characterized by autonomous excessive growth hormone (GH) secretion, generally due to GH-producing pituitary adenoma, and associated with various systemic comorbidities including diabetes mellitus. Polycystic kidney disease (PKD) the of numerous cysts in kidneys that deteriorate renal function. While possible effects GH exposure have been a current issue experimental medicine, only five cases coexisting acromegaly PKD reported previously, little known regarding influence on...
Summary Maturity-onset diabetes of the young (MODY) is a form monogenic mellitus characterised by early onset and dominant inheritance. Delayed diagnosis or misdiagnosis as type 1 2 common. Definitive genetic essential for appropriate treatment patients with MODY. The hepatocyte nuclear factor 1-beta (HNF1B) gene responsible MODY 5 (MODY5), which has distinctive clinical features including renal disease. MODY5 should always be considered clinicians in anomalies. We report case 30-year-old...