No research exists on how body mass index (BMI) changes with age over the full life span and social disparities therein. This study aims to fill gap using an innovative life-course design analytic methods model BMI trajectories from early adolescence old across 20th-century birth cohorts test sociodemographic variation in such trajectories. We conducted pooled integrative data analysis (IDA) combine four national population-based NIH longitudinal cohort studies that collectively cover...

Objectives: Cognitive aging is a lifelong process with implications for Alzheimer’s disease and dementia. This study aims to fill major gaps in research on the natural history of social disparities aging-related cognitive decline over life span. Methods: We conducted integrative data analysis four large U.S. population-based longitudinal studies individuals aged 12 105 followed two decades modeled age trajectories function multiple domains. Results: found evidence onset 4 th decade life,...

Organochlorine pesticides persist in the environment and body for extended periods. However, little is known about their long-term impact on cognition older adults if influence differs by race/ethnicity (hereinafter ethnicity) sex. We evaluated cognitive function organochlorine levels ethnicity sex 979 adults, age 60+ from National Health Nutrition Examination Surveys (2011-2014). utilized weighted linear generalized estimating equations to measure differences between seven log-transformed...

Traumatic brain injuries (TBIs) are associated with increased risk of dementia, but whether lifetime TBI influences cognitive trajectories in later life is less clear. Cognitive interventions after may improve and delay dementia. Because twins share many genes environmental factors, we capitalize on the twin study design to examine association between decline.

Percutaneous coronary intervention (PCI) is the first line of treatment for ST-elevated myocardial infarction (STEMI). This study evaluates role dementia in diagnostic cardiac catheterization (to receive PCI) STEMI patients ≥65 years old admitted to high annual volume PCI hospitals.Participants were registered Florida's comprehensive inpatient surveillance system 2006-2007 with principal diagnosis STEMI. Dementia was defined using ICD-9 codes presenile, senile, and Alzheimer's type...

ABSTRACT Background: Research shows that lipid levels may be associated with cognitive function, particularly among women. We aimed to examine total cholesterol (TC), low-density lipoprotein (LDL-C), triglycerides (TG), high-density (HDL), and HDL/LDL ratio in relation performance, measured six well-established domains a composite score (CCS). Methods: In this cross-sectional study, biomarkers neuropsychological assessment were available for 141 adults MMSE scores ≥ 24 (mean age = 69 years,...

Abstract Introduction The Alzheimer's Disease Prevention Registry (ADPR) of the Joseph and Kathleen Bryan Research Center at Duke University has been successful in achieving a racially diverse “research ready” cohort cognitively healthy volunteers. Methods ADPR is based on an infrastructure that includes: (1) administrative leadership team; (2) coordinating center; (3) IT management (4) community engagement (5) collaborations with study partners across disciplines. Results currently more...

Abstract Introduction This study leveraged the twin design, which controls for shared genetic and early life exposures, to investigate association between traumatic brain injury (TBI) dementia. Methods Members of National Academy Sciences–National Research Council's Twins Registry World War II male veterans were assigned a cognitive outcome based on multi‐step assessment protocol. History TBI was obtained via interviews. Results Among 8302 individuals, risk non‐Alzheimer's disease (non‐AD)...

Objective: We used the Physical Performance Across LifeSpan Study to investigate relationships of multiple indicators socioeconomic status (SES), both in early life and late life, with physical function. Method: examined associations between SES function measured by aerobic endurance, gait speed, lower body strength. Results: Higher participant education household income were associated increased In our age-stratified analysis, we observed widening disparities increasing age among those two...

Objective: To examine the relationship between total cholesterol (TC), triglycerides (TG), and high-density lipoprotein (HDL-C) with disability physical performance. Method: Wave 1 data were from Costa Rican Longevity Healthy Aging Study ( n = 2,827). Lipoprotein profiles measured using blood samples. Disability functioning activities of daily living/instrumental living (ADLs/IADLs) objective assessment Results: Lower HDL-C was associated greater ADL disability, lower TC longer time to...

Abstract The National Academy of Sciences-National Research Council (NAS-NRC) Twin Registry is one the oldest, national population-based twin registries in USA. It comprises 15,924 White male pairs born years 1917–1927 ( N = 31.848), both whom served armed forces, chiefly during World War II. This article updates activities this registry since most recent report and Human Genetics (Page, 2006). Records-based data include information from enlistment charts Veterans Administration linkages....

Abstract Background Dysregulation of some metabolic factors increases the risk dementia. It remains unclear if overall dysregulation, or only certain components, contribute to cognitive aging and these associations are sex specific. Methods Data from 2006–2016 waves Health Retirement Study (HRS) was used analyze 7 103 participants aged 65 older at baseline (58% women). We created a metabolic-dysregulation score (MDRS) composed blood pressure/hypertension status, glycosylated hemoglobin...

Abstract Objective: This study examined the cross-sectional association between phytoestrogens and speed of processing. We hypothesized that higher levels would be related to better cognitive performance among older women. Methods: Participants were from National Health Nutrition Examination Survey consisted 200 women (M = 74.4 y). Stepwise regressions indicators processing, measured by Digit Symbol Substitution Test. Isoflavones, lignans, individual added regression after including...

Abstract Alzheimer’s disease disproportionally impacts the Hispanic/Latino(a)x (hereafter Latino) community. Ensuring Latino representation in brain health research is essential for understanding how disorders affect this diverse population. However, recruiting Latinos into studies presents multifaceted challenges, including structural inequities, cultural beliefs, values (i.e. faith and family beliefs), immigration status. Within North Carolina Registry Brain Health (NC Registry), we have...

Abstract Objective This study explores the link between cardiometabolic biomarkers and neurocognition in older American Indians, focusing on diet quality as measured by Healthy Eating Index (HEI). Methods Participants provided biological specimens completed health, diet, exposome questionnaires a mobile clinic. Cardiometabolic (lipids, glucose) were with Cholestech LDX Analyzer log-transformed. Neurocognition was assessed using Montreal Cognitive Assessment (MoCA). OLS regressions, adjusted...

Abstract Objective This collaborative pilot project assessed the feasibility of enrolling 50 older adults from underrepresented populations in Robeson County, North Carolina (NC), considered a racially diverse and socioeconomically disadvantaged area. Methods The study protocol, adapted Alzheimer’s Gut Microbiome Project, was modified to fit local cultural contexts with input community academic partners. Lumbee Tribe NC, headquartered its Tribal IRB endorsed community-informed recruitment...

Abstract Background Neurocognitive health is influenced by multiple modifiable and non‐modifiable lifestyle factors. Machine learning tools offer a promising approach to better understand complex models of cognitive function. We used extreme gradient boosting (XG Boost), an algorithm decision‐tree modeling, analyze the association between 15 late‐life demographic factors with episodic memory performance. Method Our dataset consisted 2247 participants from KHANDLE STAR cohorts. Participants...

Objective: Social support may protect against Alzheimer’s disease and related dementias (ADRD), potentially through emotional or instrumental elements. Black Hispanic/Latinx older adults bear a disproportionate burden of ADRD. However, independent effects on cognition, primary indicator ADRD risk, are largely understudied in these groups. Guided by the differential vulnerability hypothesis – theoretical framework which posits that systemic racism disadvantages individuals’ health we...

Abstract Background Prior studies have shown that volunteering in late life is associated with better physical health, social activity, and cognition, but the bulk of evidence limited to non‐Latino White or Asian populations. The purpose this analysis was determine whether differences domain‐specific cognition cognitive change a diverse cohort. Method Kaiser Healthy Aging Diverse Life Experiences Study (KHANDLE) African Americans (STAR) are harmonized cohort long‐term Permanente members ages...

Abstract Background Traumatic brain injury (TBI) is associated with increased risk of dementia, but whether TBI influences cognitive trajectories in later life less clear. Identifying those at high‐risk decline creates intervention opportunities to delay dementia. Since twins share many genes and environmental factors, we capitalize on the twin‐study design investigate association between lifetime decline. Method Participants (n = 8,662) members National Academy Sciences‐National Research...

Abstract Background Diverse racial/ethnic representation in scientific studies is crucial for generalizability of results and development potentially effective treatments. Racially diverse registries with research ready individuals have the potential to fill this gap. However, despite having signed up as part a registry being invited participate clinical trials, many do not participate. To better understand participation, NC Registry Brain Health surveyed its members identify characteristics...