A5027376492- Autoimmune and Inflammatory Disorders Research
- Orthopedic Infections and Treatments
- Infectious Diseases and Tuberculosis
- Immunodeficiency and Autoimmune Disorders
- Streptococcal Infections and Treatments
- Hematological disorders and diagnostics
- Adolescent and Pediatric Healthcare
- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Child and Adolescent Health
- Musculoskeletal Disorders and Rehabilitation
- Osteomyelitis and Bone Disorders Research
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Viral Infections and Immunology Research
- Innovations in Medical Education
- Pericarditis and Cardiac Tamponade
- Therapeutic Uses of Natural Elements
- Infective Endocarditis Diagnosis and Management
- Blood groups and transfusion
- Inflammatory Myopathies and Dermatomyositis
- IgG4-Related and Inflammatory Diseases
- Pomegranate: compositions and health benefits
- SARS-CoV-2 and COVID-19 Research
- Alkaline Phosphatase Research Studies
Hospital Universitario La Paz
2016-2025
Hospital Ruber Internacional
2024
Universidad Complutense de Madrid
2020-2022
Hospital Materno-Infantil
2016-2021
Hospital Universitario del Sureste
2021
Weatherford College
2021
Hospital La Paz Institute for Health Research
2020
Hospital Universitario Severo Ochoa
2016
Hospital Virgen del Camino
2016
Acute osteoarticular infection (OAI) is a potentially severe disease. The aim of this study was to evaluate the etiology, clinical characteristics and therapeutic approach OAI in children Spain.Medical records from <14 years with 25 hospitals between 2008 2012 were reviewed. Confirmed osteomyelitis (OM) septic arthritis (SA) required positive bacterial isolate; otherwise, they considered probable. Probable SA <40,000 cells/mm joint fluid not included.A total 641 evaluated. Two hundred...
Anti-melanoma differentiation-associated gene 5 juvenile dermatomyositis (anti-MDA5 JDM) is associated with high risk of developing rapidly progressive interstitial lung disease (RP-ILD). Here we report an 11-year-old girl anti-MDA5 JDM and RP-ILD which led to a fatal outcome, further aggravated by SARS-CoV-2 infection. She was referred our hospital after being diagnosed respiratory failure due RP-ILD. On admission, fibrobronchoscopy bronchoalveolar lavage (BAL) revealed Pneumocystis...
Bone and joint infections (BJIs) in children adolescents have traditionally required intravenous (IV) antibiotic treatment hospitalization, which implications for the patients, their families, health resources antimicrobial stewardship.1 Historically, has involved extended IV therapy of 1–6 weeks, primarily based on expert opinions retrospective studies.2,3 However, many settings, recommended changed during 2010s to a short individualized phase 2–4 days, followed by oral antibiotics 1–2...
To standardly assess and describe nailfold videocapillaroscopy (NVC) assessment in children adolescents with juvenile rheumatic musculoskeletal diseases (jRMD) vs healthy controls (HCs).In consecutive jRMD matched HCs from 13 centres worldwide, 16 NVC images per patient were acquired locally read centrally international consensus standard evaluation of the EULAR Study Group on Microcirculation Rheumatic Diseases. A total 95 patients JIA, 22 JDM, 20 childhood-onset SLE (cSLE), SSc (jSSc), 21...
Osteoarticular infections (OAIs) are typically treated initially with intravenous antibiotics. The objective of this study was to evaluate whether an exclusive oral treatment in selected children may be appropriate.The Spanish Network Infections is a nationwide multicenter registry comprising 37 hospitals Spain. prospectively includes clinical characteristics and outcome OAI. One the from RioPed offers meeting certain criteria. Patients were classified into 2 groups. Group 1: management...
Abstract Aim The traditional approach for acute paediatric osteoarticular infections (OAI) has comprised initial intravenous antibiotics followed by prompt oral antibiotics. We assessed how providing just compared to the two‐step approach. Methods This prospective study was performed at Hospital La Paz, Madrid, Spain, from September 2015 2016. 25 outpatients, with good general health and a mean age of months who received antibiotics, 228 hospitalised children similar other hospitals in...
Juvenile idiopathic arthritis (JIA) is a complex rheumatic disease with both autoimmune and autoinflammatory components. Recently, familial cases of systemic-onset JIA have been attributed to mutations in LACC1/FAMIN. We describe three affected siblings from Moroccan consanguineous family an early-onset chronic, symmetric erosive previously diagnosed as rheumatoid factor (RF)-negative polyarticular JIA. Autozygosity mapping identified four homozygous regions shared by all patients, located...
Abstract Background Data about safety and efficacy of the mRNA SARS-CoV-2 vaccine in adolescents with rheumatic diseases (RD) is scarce whether these patients generate a sufficient immune response to remains an outstanding question. Objective To evaluate humoral cellular immunity BNT162b2 12 18 years RD immunosuppressive treatment compared healthy control group. Methods Adolescents from followed at Hospital La Paz Madrid ( n = 40) receiving vaccination were assessed 3 weeks after complete...
To evaluate the efficacy of colchicine therapy in pediatric patients with PFAPA syndrome who present an incomplete response to standard treatment or frequent episodes (an interval less than 14 days between two disease flares).A multicenter cohort study children diagnosed and treated was performed three separate hospitals located Spain. The clinical laboratory data were reviewed by accessing their medical records. Response evaluated after 12 months for frequency, duration, intensity...
We identified a consanguineous Moroccan family with three affected siblings diagnosed rheumatoid factor-negative polyarticular juvenile idiopathic arthritis. They all suffered from an early-onset (2-4 years-old) chronic and symmetric polyarthritis affecting both large small joints. The joint involvement was markedly erosive in two siblings, the older sister requiring hip prosthetic replacement at age of 18 years. None patients had fever, skin rash, uveitis or other extra-articular...
Children with juvenile idiopathic arthritis (JIA) might be at a higher risk of infection. Our objectives are to describe and compare infection rates in patients JIA vs. healthy patients.A prospective, multicenter observational study was performed Spain from January 2017 June 2019. Patients 7 participating hospitals children without (siblings JIA, non-JIA primary health centers) were followed up quarterly questionnaires record episodes. Tuberculosis, herpes zoster, infections requiring...
OPINION article Front. Pediatr., 11 November 2022Sec. Pediatric Infectious Diseases https://doi.org/10.3389/fped.2022.1017035
This study aims to evaluate the impact of PCR multiplex panel (BioFire JI
La espondilodiscitis pediátrica (EDP) es una afección poco común, para la cual no existen guías clínicas internacionales específicas. No se han establecido factores relacionados con las complicaciones. Nuestro objetivo fue describir características y epidemiológicas de EDP, analizar los asociados al desarrollo complicaciones evaluar el cumplimiento recomendaciones del Documento consenso nacional (DCN) español abordaje diagnóstico terapéutico infecciones osteoarticulares agudas. Estudio...
Pediatric spondylodiscitis (PSD) is an uncommon condition, for which there are no specific international clinical guidelines. Factors related to complications have not been stablished. Our aim was describe and epidemiological characteristics of PSD, analyze factors associated with evaluate adherence the recommendations Spanish National Consensus Document (NCD) diagnostic therapeutic approach acute osteoarticular infections.