Abstract Carcinogenesis involves the chemical and structural alteration of biomolecules in cells. Aberrant methylation DNA is a well-known carcinogenic mechanism common modification DNA. Terahertz waves can directly observe changes because characteristic energies lie same frequency region. In addition, terahertz energy levels are not high enough to damage by ionization. Here, we present molecular resonance fingerprints cancer Methylated cytidine, nucleoside, has that give rise Molecular...

We report that single-stranded deoxyribonucleic acids (ssDNAs) at very low concentrations can be detected using graphene-combined nano-slot-based terahertz (THz) resonance. A combination of the resonant structure and tuned electro-optical properties graphene provide unprecedentedly sensitive biomolecule sensing even energy THz photons, overcoming huge scale difference 10,000:1 between wavelength size ssDNAs. Ultrahigh sensitivity is obtained by significant increase in absorption...

Discrimination and quantification of trace amounts steroid hormones in biological specimens are needed to elucidate their changing expression because functions responsible for the development prevention endocrine disorders. Although mass-spectrometry-based assays most commonly recommended, a new type highly sensitive selective detection methods clinical practices is needed. Here, we introduce label-free terahertz molecule sensor capable sensing identifying progesterone 17α-OH-progesterone...

Terahertz (THz) technology has become more widespread due to its diverse range of potential applications, particularly when combined with various functional metamaterials using cutting-edge nanotechnology techniques. In this report, we introduce a highly improved THz imaging by comparing complementary intuitively based on Babinet's principle. The reflectance spectra for the exhibit significant and distinct association polarization angle. Four different angles metamaterial pattern geometries...

The development of effective assay techniques for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently received research attention due to its rapid worldwide spread and considerable risk human health. receptor-binding domain (RBD) the spike (S) protein in SARS-CoV-2, a key component viral entry that unique sequence compared other structural proteins, been considered an important diagnostic target. In this respect, low-frequency vibrational modes have advantage providing...

Abstract Bioelectrodes have been developed to efficiently mediate electrical signals of biological systems as stimulators and recording devices. Recently, conductive hydrogels garnered great attention emerging materials for bioelectrode applications because they can permit intimate/conformal contact with living tissues tissue‐like softness. However, administration control over the in vivo lifetime bioelectrodes remain challenges. Here, injectable (ICHs) tunable degradability implantable are...

A flexible diagnostic platform is realized and its performance demonstrated for early detection of avian influenza virus (AIV) subtype H1N1 DNA sequences. The key component the high‐performance biosensors based on high output currents low power dissipation Si nanowire field effect transistors (SiNW‐FETs) fabricated 100 μm thick polyimide foils. devices a polymeric support are about ten times lighter compared to their rigid counterparts wafers can be prepared large areas. While latter...

Capacitive deionization (CDI) is a promising technique that can be applied to the removal ions of radioactive liquid waste. Carbon-based electrodes, which are mainly used in CDI systems, show limited characteristics due their inferior selectivity and adsorption performance target components present feed water. Prussian blue analogues (PBAs) proposed as an electrode material operates by reversible redox reaction, provides strategy efficiently remove cesium (Cs) from aqueous solutions owing...

Terahertz (THz) imaging is a nondestructive, label-free, rapid technique which gives the possibility of real-time tracing drugs within skin. We evaluated feasibility THz dynamic for visualizing serial changes in distribution and penetration topical agent, dimethyl sulfoxide (DMSO) containing ketoprofen, using excised mouse skins. was performed 6 h after drug application to skin compared with results obtained Franz cell diffusion test, standard vitro absorption test. reflection showed that...

Abstract Probing the kinetic evolution of nanoparticle (NP) growth in liquids is essential for understanding complex nano‐phases and their corresponding functions. Terahertz (THz) sensing, an emerging technology next‐generation laser photonics, has been developed with unique photonic features, including label‐free, non‐destructive, molecular‐specific spectral characteristics. Recently, metasurface‐based sensing platforms have helped trace biomolecules by overcoming low THz absorption...

In this paper, a new fast terahertz reflection tomography is proposed using block-based compressed sensing. Since measuring the time-domain signal on two-dimensional grid requires excessive time, reducing measurement time highly demanding in tomography. The technique directly reduces number of sampling points spatial domain without modulation or transformation signal. Compressed sensing suggests reconstruction, which substantially computational degrading image quality. An overlap-average...

We introduce a robust control method of terahertz (THz) transmission by tuning filling factors Au nanoparticles (AuNPs) inside nano slot antennas. AuNPs in sub-100 nm diameters were spread over the antennas, followed sweeping them into slots. can be efficiently localized and inserted slots where THz fields are greatly enhanced, "squeegee" made polydimethylsiloxane (PDMS). The results further dramatic reduction suppressing fundamental resonance mode slot, as compared to typical random...

We investigate spectral responses of two different terahertz (THz) metamaterials double split ring resonator (DSRR) and the nano slot (NSR) for molecule sensing in low concentration. Two resonant frequencies DSRR can be controlled by polarization angle incident THz beam. For comparison optical characteristics, NSRs were made as showing same DSRR's multimode. The monosaccharide molecules glucose galactose detected these types matching various NSR shows higher sensitivity very concentration...

This study presents a new design method for zoom lens, in which real lens groups are designed successively to combine form modules system. The and aberrations applied the initial four-group inner-focus An with focal length range of 4.2 39.9 mm is derived by assigning first-order quantities third-order each module along constraints required optimum solutions. After obtaining system, successively, not separately, get Compared separately groups, this approach can give better starting save time....

Vapor sensors, aka electronic noses, are becoming an increasingly popular analytical tool for detection and identification of small molecules in the gas phase. In this paper, we present results a series experiments demonstrating real-time vapor phase cocaine molecules. A distinctive response or signature was observed under laboratory conditions which vapors were presented using INEL generator "field" facilitated by Georgia Bureau Investigation (GBI) Crime Lab. For these experiments, sensor...

Terahertz waves have gained attention owing to their potential for various bio-applications, including broadband spectroscopy, imaging, and sensing. For development of practical applications in clinical fields, highly sensitive molecular detection is essential. Notably, the sensitivity optical sensing can be enhanced by utilizing localized electromagnetic metallic resonators. In this study, we theoretically design terahertz (THz) metamaterial sensors based on Fano resonance, enabling...

A novel micromachining process based on the UV-LIGA and (110) silicon anisotropic etching to fabricate a high-aspect-ratio comb actuator was developed. The electrodes were fabricated by spring structures using process. structure designed considering etch-rate-ratio between (111) planes lateral etch rate of line-type structure. 400 μm thick 18 wide separated 7 height–gap ratio approximately 57. In addition, number, width, height length resonant frequency frequency-matching sensing driving...