A5048781587- Reproductive Physiology in Livestock
- Genetic and phenotypic traits in livestock
- Ruminant Nutrition and Digestive Physiology
- Immune Cell Function and Interaction
- Milk Quality and Mastitis in Dairy Cows
- Infant Nutrition and Health
- Animal Genetics and Reproduction
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Diet, Metabolism, and Disease
- Cancer Immunotherapy and Biomarkers
- Animal health and immunology
- Mesenchymal stem cell research
- Chronic Lymphocytic Leukemia Research
- Immune Response and Inflammation
- Cancer, Stress, Anesthesia, and Immune Response
- Heat shock proteins research
- Metabolomics and Mass Spectrometry Studies
- Autophagy in Disease and Therapy
- IL-33, ST2, and ILC Pathways
- Ferroptosis and cancer prognosis
- Adipose Tissue and Metabolism
- Meat and Animal Product Quality
- Polyamine Metabolism and Applications
Cornell University
2022-2024
University of Illinois Urbana-Champaign
2018-2023
Urbana University
2018-2019
Abstract Background We aimed to characterize the protective effects and molecular mechanisms of action a Saccharomyces cerevisiae fermentation product (NTK) in response mastitis challenge. Eighteen mid-lactation multiparous Holstein cows ( n = 9/group) were fed control diet (CON) or CON supplemented with 19 g/d NTK for 45 d (phase 1, P1) then infected right rear quarter 2500 CFU Streptococcus uberis 2, P2). After 36-h, mammary gland liver biopsies collected antibiotic treatment started until...
To reduce costs of rearing replacement heifers, researchers have focused on decreasing age at breeding and first calving. increase returns upon initiation lactation the focus has been increasing mammary development prior to onset lactation. Enhanced plane nutrition pre-weaning may benefit entire heifer operation by promoting gland greater future production.Twelve Holstein calves (< 1 week old) were reared 2 dietary treatments (n = 6/group) for 8 weeks: a control group fed restricted milk...
We investigated how prepartal body condition score (BCS) alters key hepatic enzymes associated with 1-carbon, carnitine, and glutathione metabolism the related biomarkers in liver tissue plasma of periparturient dairy cows. Twenty-six multiparous Holstein cows were retrospectively selected according to BCS at 4 wk prepartum divided into high (HighBCS, ≥ 3.50) normal (NormBCS, ≤ 3.25) groups (n = 13 each). Blood samples obtained −30, −10, 7, 15, 30 d relative calving. Liver biopsies performed...
Vitamin B12 plays a role in the remethylation of homocysteine to Met, which then serves as substrate for Met adenosyltransferase (MAT) synthesize S-adenosylmethionine (SAM). We investigated effects feeding two cobalt sources [Co-glucoheptonate (CoPro) or CoPectin, Zinpro Corp.], an experimental ruminally-available source folic acid (FOA), and rumen-protected (RPM) on performance hepatic one-carbon metabolism peripartal Holstein cows. From -30 30 d around calving, 72 multiparous cows were...
Peripartal cows mobilize not only body fat but also protein to satisfy their energy requirements. The objective of this study was determine the effect prepartum BCS on blood biomarkers related and nitrogen metabolism, mRNA abundance associated with AA metabolism insulin signaling in subcutaneous adipose tissue (SAT) peripartal cows. Twenty-two multiparous Holstein were retrospectively classified into a high (HBCS; n = 11, ≥ 3.5) or normal (NBCS; ≤ 3.17) group at d 28 before expected...
Abstract Background Diffuse large B cell lymphoma (DLBCL) is the most frequent subtype of non-Hodgkin lymphomas (B-NHLs). B-NHLs respond poorly to currently available immune checkpoint blockade (ICB) therapies, such as anti-PD-1 or anti-CTLA-4 + combination and reason for this unknown. New genetic classifications DLBCL have been recently proposed, providing rationale studying ICB resistance mechanisms according these novel molecular subtypes. Methods Genetic aberration involving Bcl2 EZH2...
Choline requirements for dairy cattle are unknown. However, enhanced postruminal supply of choline may increase flux through the methionine cycle to spare Met other functions such as protein synthesis and phosphatidylcholine (PC) during periods negative nutrient balance (NNB). The objective was investigate effects a feed restriction-induced NNB on hepatic abundance phosphorylation mTOR (mechanistic target rapamycin)-related signaling proteins, lipidome plasma AA. Ten primiparous...
Abstract Immune checkpoint proteins are key regulators of the immune system and drug targets cancer immunotherapy. molecules have been found on cell surface various tumor cells as activating or inhibitory receptors ligands. Recent studies shown these can undergo alternative splicing proteolytic cleavage leading to soluble isoforms. IFNγ is a pleiotropic multifunctional cytokine commonly released by cytotoxic cells. production be enhanced in response immunotherapy further modulates expression...
Introduction: Germinal center B-cell(GCB)-like diffuse large B-cell lymphomas and follicular resemble GCB cells, which are normally controlled by CD4+ T helper (Tfh) cells. Gain-of-function (GOF) mutations in the methyltransferase EZH2 (e.g., EZH2Y641F) contribute to these diseases downregulating antigen presentation molecules for T-cell recognition, including MHC-II. Cytolytic cells have a limited capacity enter GCs, facilitates outgrowth of sites. Conversely, immunosuppressive CD4+Foxp3+...