A5081931507- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Tuberculosis Research and Epidemiology
- Synthesis and Biological Evaluation
- Quinazolinone synthesis and applications
- Synthesis and biological activity
- Fluorine in Organic Chemistry
- Crime Patterns and Interventions
- HIV/AIDS drug development and treatment
- Chronic Myeloid Leukemia Treatments
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- Biotechnology and Related Fields
- Eosinophilic Disorders and Syndromes
- Science and Education Research
- Policing Practices and Perceptions
- Pneumocystis jirovecii pneumonia detection and treatment
- Coenzyme Q10 studies and effects
- Violence, Education, and Gender Studies
- Mycobacterium research and diagnosis
- Synthesis of β-Lactam Compounds
- Crystallization and Solubility Studies
- Criminal Justice and Corrections Analysis
- Immune Response and Inflammation
Fundação Oswaldo Cruz
2014-2024
Universidade de São Paulo
2020
Universidade Federal do Rio de Janeiro
2012-2018
Universidade Federal Fluminense
2017
Centro Universitário da Cidade
2012
Abstract Background Current approaches of drug repurposing against COVID-19 have not proven overwhelmingly successful and the SARS-CoV-2 pandemic continues to cause major global mortality. nsp12, its RNA polymerase, shares homology in nucleotide uptake channel with HCV orthologue enzyme NS5B. Besides, NS5A has pleiotropic activities, such as binding, that are shared various proteins. Thus, anti-HCV NS5B inhibitors, like sofosbuvir daclatasvir, respectively, could be endowed anti-SARS-CoV-2...
Abstract Current approaches of drugs repurposing against 2019 coronavirus disease (COVID-19) have not proven overwhelmingly successful and the severe acute respiratory syndrome 2 (SARS-CoV-2) pandemic continues to cause major global mortality. Daclatasvir (DCV) sofosbuvir (SFV) are clinically approved hepatitis C virus (HCV), with satisfactory safety profile. DCV SFV target HCV enzymes NS5A NS5B, respectively. is endowed pleotropic activities, which overlap several proteins from SARS-CoV-2....
Searching for new substances with antileishmanial activity, we synthesized and evaluated a series of α,α-difluorohydrazide α,α-difluoramides against Leishmania amazonensis arginase (LaArg). Four derivatives showed activity LaArg Ki in the range 1.3–26 μM. The study kinetics inhibition that these might act via different inhibitory mechanisms or even by combination these. compounds were tested L. promastigotes best result was obtained to compound 4 (EC50 12.7 ± 0.3 μM). In addition, order...
Chagas disease is a tropical neglected that affects millions of people worldwide, still demanding more effective and safer therapy, especially in its chronic phase which lacks treatment promotes substantial parasitological cure. The technical note Romanha collaborators published 2010 aimed establish guideline with the set minimum criteria decision gates for development new agents against Trypanosoma cruzi focus on developing antichagasic drugs. In this sense, present review aims to update...
Tuberculosis (TB) is one of the top ten causes death worldwide, while Chagas disease (CD) parasitic that kills largest number people in Americas. TB leading cause for patients with AIDS; it 1.5 million and 10 new cases every year. The lack newly developed chemotherapeutic agents insufficient access to health care services a diagnosis increase incidence multidrug-resistant (MDRTB) cases. Although CD was identified 1909, chronic stages still adequate treatment.The purpose this work design...
Nuclear magnetic resonance is a technique that widely used for elucidating and characterizing organic substances.Organofluorine substances have applications in many areas from drugs to liquid crystals, but their NMR spectra are often challenging due fluoride coupling with other nuclei.For this reason, of class not commonly covered undergraduate graduate chemistry courses related fields.Thus, the aim work was presentation discussion 1 H, 13 C, 19 F eleven organofluorine which, case H C...
Chagas disease (CD), which is caused by Trypanosoma cruzi and was discovered more than 100 years ago, remains the leading cause of death from parasitic diseases in Americas. As a curative treatment only available for acute phase CD, search new therapeutic options urgent. In this study, nitroazole azole compounds were synthesized underwent molecular modeling, anti-T. evaluations nitroreductase enzymatic assays. The designed as possible inhibitors ergosterol biosynthesis and/or substrates...
Fluconazole is an azolic second-generation antifungal drug and part of the National List Essential Drugs (RENAME) Brazilian Ministry Health.It considered as first choice for treatment some opportunistic fungal infections also applied in AIDS program prophylactic therapy to avoid these infections.Due importance fluconazole Health System (SUS), it strategic domain its obtaining process.Thus, improvements synthesis this substance are special interest.In work, many changes were proposed carried...
The enzyme tyrosine kinase BCR-Abl-1 is the main molecular target in treatment of chronic myeloid leukemia and can be competitively inhibited by inhibitors such as imatinib. New potential competitive were synthesized using (phenylamino)pyrimidine-pyridine (PAPP) group a pharmacophoric fragment, these compounds biologically evaluated. synthesis twelve new was performed three steps assisted microwave irradiation 1,3-dipolar cycloaddition to obtain 1,2,3-triazole derivatives substituted on...
Chagas disease is a neglected tropical parasitic caused by the protozoan Trypanosoma cruzi. Worldwide, an estimated 8 million people are infected with T. cruzi, causing more than 10,000 deaths per year. Currently, only two drugs, nifurtimox and benznidazole (BNZ), approved for its treatment. However, both ineffective during chronic phase, show toxicity, produce serious side effects. This work aimed to obtain evaluate novel 2-nitroimidazole-N-acylhydrazone derivatives analogous BNZ. The...
A doenca de Chagas e uma tropical negligenciada que afeta mais 10 milhoes pessoas em todo mundo ameaca outras 25 vivem areas risco. E ste trabalho descreve como os inibidores da enzima 14alfa-desmetilase (CYP51) foram explorados com base na estrategia “piggyback approach”, termo ingles a nova aplicacao para um farmaco ou prototipo originalmente desenvolvido outra patologia, onde, neste caso, investigados contra o Trypanosoma cruzi . Desta forma, mostrado classe dos azois atua inibicao deste...
There are only two drugs for the treatment of Chagas disease, namely, nifurtimox and benznidazole, that can cause several adverse effects. Despite effectiveness these in disease's acute phase, they not recognized as curative chronic establishing need more effective all stages disease. Cruzain is an enzyme plays a vital role life cycle etiologic agent, protozoan Trypanosoma cruzi, being relevant therapeutic target planning new drugs. Using molecular docking dynamics simulations, we have...
Tuberculosis is a serious public health problem, especially in underdeveloped or developing countries. The first line antiTB treatment was developed more than 40 years ago, and this, addition to the development of strains Mycobacterium tuberculosis resistant multiple drugs co-infection with AIDS virus, has worsened situation this disease worldwide. urgent need for new active against multidrug-resistant capable concurrently use led efforts by pharmaceutical industries governmental...
Chagas disease is a neglected tropical that affects more than 10 million people worldwide and threatens other 25 who live in areas of risk.In this work, it described how inhibitors the enzyme 14α-demethylase (CYP51) were explored based piggyback approach, which strategy used to find new applications for known drugs or leads, case, against Trypanosoma cruzi.It shown azole class acts inhibition target, key process ergosterol biosynthesis, major sterol parasite.Their synthetic routes are detail...
Tuberculosis is a serious public health problem, especially in underdeveloped or developing countries.The first line anti-TB treatment was developed more than 40 years ago.In addition to the development of strains Mycobacterium tuberculosis resistant multiple drugs and co-infection with AIDS virus, has worsened situation this disease worldwide.The urgent need for new therapeutic options active against multidrug-resistant concurrently capable be used led industries, governments...
The Nuclear Magnetic Resonance (NMR) is a technique that has many applications in chemistry, biochemistry and medical sciences.Within the NMR spectra allow elucidation characterization from small molecules of synthetic or natural origin, to macromolecules their interactions with ligands.However, cases, edition restricted proprietary software workstations are part system, being performed by operator equipment, which undoubtedly can delay performance new analyzes, as well generate lacks some...