A5035826389- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Hepatitis C virus research
- Biotechnology and Related Fields
- Mosquito-borne diseases and control
- Extracellular vesicles in disease
- Chromosomal and Genetic Variations
- Genetics, Bioinformatics, and Biomedical Research
- Science and Education Research
- Bacillus and Francisella bacterial research
- Viral Infections and Outbreaks Research
- Urban and Rural Development Challenges
- Poxvirus research and outbreaks
- Viral Infections and Immunology Research
- Computational Drug Discovery Methods
- Immune responses and vaccinations
- Synthesis and biological activity
- Healthcare Regulation
- Cytomegalovirus and herpesvirus research
- Transgenic Plants and Applications
- Pharmacological Receptor Mechanisms and Effects
- Viral Infections and Vectors
- Nutrition, Genetics, and Disease
- COVID-19 epidemiological studies
Fundação Oswaldo Cruz
2020-2025
Faculdades Oswaldo Cruz
2022
Universidade Federal do Rio de Janeiro
2021
MGI
2021
Abstract Background Current approaches of drug repurposing against COVID-19 have not proven overwhelmingly successful and the SARS-CoV-2 pandemic continues to cause major global mortality. nsp12, its RNA polymerase, shares homology in nucleotide uptake channel with HCV orthologue enzyme NS5B. Besides, NS5A has pleiotropic activities, such as binding, that are shared various proteins. Thus, anti-HCV NS5B inhibitors, like sofosbuvir daclatasvir, respectively, could be endowed anti-SARS-CoV-2...
Critically ill 2019 coronavirus disease (COVID-19) patients under invasive mechanical ventilation (IMV) are 10 to 40 times more likely die than the general population. Although progression from mild severe COVID-19 has been associated with hypoxia, uncontrolled inflammation, and coagulopathy, mechanisms involved in severity poorly understood.The virome of tracheal aspirates (TA) 25 IMV was assessed through unbiased RNA sequencing (RNA-seq), correlation analyses were conducted using available...
Abstract Current approaches of drugs repurposing against 2019 coronavirus disease (COVID-19) have not proven overwhelmingly successful and the severe acute respiratory syndrome 2 (SARS-CoV-2) pandemic continues to cause major global mortality. Daclatasvir (DCV) sofosbuvir (SFV) are clinically approved hepatitis C virus (HCV), with satisfactory safety profile. DCV SFV target HCV enzymes NS5A NS5B, respectively. is endowed pleotropic activities, which overlap several proteins from SARS-CoV-2....
Because of growing inequalities, more than one-third the worldwide population is expected to live in slums by 2050. Although slum dwellers are at increased risk infectious diseases, this may have been overlooked with respect sustainability virus evolution. In study, we aimed analyze genetic diversity and evolution SARS-CoV-2 Complexo de Favelas da Maré slum, Rio Janeiro, Brazil, assess its impact on global spread virus. We found that harbored multiple strains SARS-CoV-2, amplification...
Ilhéus Virus (ILHV) was first detected in 1944 Ilhéus, state of Bahia, northeast Brazil. During cellular infection, orthoflaviviruses induce changes related both to the replication process, formation complexes, and structures resulting from damage. Although more detailed data are available literature for other orthoflaviviruses, relationship between ILHV, these structures, its cycle, remains unknown. One main objectives this study is characterize primary ultrastructural green monkey kidney...
Abstract The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced episodes disease (COVID-19) March and late May 2020. In the first episode, manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. second episode associated different SARS-CoV-2 strains, higher viral loads, clinical...
Despite the development of specific therapies against severe acute respiratory coronavirus 2 (SARS-CoV-2), continuous investigation mechanism action clinically approved drugs could provide new information on druggable steps virus–host interaction. For example, chloroquine (CQ)/hydroxychloroquine (HCQ) lacks in vitro activity SARS-CoV-2 TMPRSS2-expressing cells, such as human pneumocyte cell line Calu-3, and likewise, failed to show clinical benefit Solidarity Recovery trials. Another...
According to the last 2023 Monkeypox (Mpox) Outbreak Global Map from Centres for Disease Control and Prevention (CDC), more than 100 countries with no Mpox infection report cases. Brazil stands out in this group is second country highest number of cases outbreak.To contribute knowledge virus effects a cellular model, which important diagnosis infections not yet included provider´s differential developing viral inhibition strategies.We describe isolation protocol human clinical sample patient...
The global coronavirus disease 2019 (COVID-19) pandemic, caused by the highly infectious severe acute respiratory syndrome 2 (SARS-CoV-2), had resulted in significant mortality worldwide. In 2020, World Health Organization started solidarity clinical trial to assess efficacy of four proposed therapeutic strategies, including chloroquine (CQ), a 4-aminoquinoline molecule. However, CQ lacks benefit and, therefore, failed show vitro anti-SARS-CoV-2 activity TMPRSS2-expressing cells, such as...
Coronavirus disease 2019 (COVID-19) still causes death in elderly and immunocompromised individuals, for whom the sustainability of vaccine response may be limited. Antiviral treatments, such as remdesivir or molnupiravir, have demonstrated limited clinical efficacy. Nirmatrelvir, an acute respiratory syndrome coronavirus 2 (SARS-CoV-2) major protease inhibitor, is clinically effective but has been associated with viral rebound antiviral resistance. It thus necessary to study novel...
Background: The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remains poorly understood. We added to the registered case reports of in USA, Belgium/Netherlands, Ecuador and Hong Kong, a small cluster individuals with two episodes 2019 disease (COVID-19). Virus genomic analysis host immune response were used characterize this group. Methods: Four from Rio de Janeiro, Brazil, clinical manifestations COVID-19 on March again late May 2020 studied....
Abstract Repositioning of clinical approved drugs could represent the fastest way to identify therapeutic options during public health emergencies, majority explored for repurposing as antivirals 2019 coronavirus disease (COVID-19) have failed demonstrate benefit. Without specific antivirals, severe acute respiratory syndrome 2 (SARS-CoV-2) pandemic continues cause major global mortality. Antimalarial drugs, such chloroquine (CQ)/hydroxychloroquine (HCQ) and mefloquine emerged potential...
No final do ano de 2019, um vírus desconhecido se espalhou repentinamente no mundo, causando uma síndrome respiratória aguda grave [1]. A severidade da doença e a forma rápida transmissão ligou o alerta em todo mundo como emergência saúde pública, resultado, milhões pessoas estavam sendo acometidas rapidamente milhares mortes ocorrendo diariamente [2]. Dessa forma, as principais questões precisavam ser respondidas, como: agente etiológico causador doença, formas transmissão, características...
Muitas vezes quando falamos sobre a história da genética ou computação, negligenciamos o contexto histórico em que os principais eventos ocorreram, concentramos apenas nas evoluções científicas e no progresso ocorreram até momento presente. Raramente lemos influência conjuntura política nesses avanços. Essa abordagem pode nos levar acreditar as ciências naturais matemáticas são objetivas, imparciais desconectadas economia. Neste artigo, nosso objetivo é realizar uma revisão de alguns...
Você já parou para pensar na quantidade de microrganismos existentes no mundo? E nosso corpo? Claro, que como sempre, não estamos sozinhos mundo e nem próprio corpo. Atualmente, sabe-se mais 1000 espécies habitam corpo, fazendo parte do microbioma [1]. O termo microbioma, cunhado pelo vencedor prêmio Nobel, Joshua Lederberg, pode ser descrito como: “Um sistema ecológico comensais, simbióticos também patogênicos residem corpo humano” [2]. Possuir um é algo exclusivo humano, podemos utilizar o...