A5047844526- Cerebral Venous Sinus Thrombosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Parkinson's Disease Mechanisms and Treatments
- Metabolism and Genetic Disorders
- Peripheral Neuropathies and Disorders
- Acute Ischemic Stroke Management
- Genetic and rare skin diseases.
- Glioma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Biochemical and Molecular Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Body Image and Dysmorphia Studies
- Ocular Oncology and Treatments
- Neurosurgical Procedures and Complications
- Genetic Neurodegenerative Diseases
- Cutaneous Melanoma Detection and Management
- Healthcare Quality and Management
- Quality and Safety in Healthcare
- Restless Legs Syndrome Research
- Quality and Supply Management
- Female Genital Mutilation/Cutting Issues
- Venous Thromboembolism Diagnosis and Management
- Parkinson's Disease and Spinal Disorders
- CNS Lymphoma Diagnosis and Treatment
- Sleep and Wakefulness Research
National Institute of Mental Health and Neurosciences
2019-2025
Christie's
2022
Neurology, Inc
2019
Glutaric aciduria type-1 (GA-1) is a rare metabolic disorder due to mutation in GCDH gene resulting varied clinical manifestations. Here we report case of late-onset GA-1 with acute myelo-neuropathy and chronic renal failure. Institutional ethics committee approval was obtained genetic analysis done by exome sequencing. present 19 year-old-adolescent male disease for 2 years presented 5 months history sudden onset weakness proximal distal lower limbs bladder retention. This preceded...
Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder pathologically characterized by localized neuronal loss, and presence of eosinophilic inclusions in neurons glial cells.A 50-year-old man presented with rapidly progressive dementia, behavioral changes, gait disturbances, incontinence 3 months duration. His brain magnetic resonance imaging showed diffuse T2/FLAIR hyperintensity basal ganglia, thalami, cerebral peduncles, ventral pons, supratentorial white...
Abstract Hyperammonemia is a rare cause of adult episodic encephalopathy. Citrin deficiency resulting in citrullinemia type 2 (CTLN2) can lead to recurrent delirium adults. Here we report case onset encephalopathy due citrin deficiency. A 40 years old male presented with one-year history triggered by high protein and fat diet. He also had chronic pancreatitis subacute intestinal obstruction which novel manifestation CTLN2. Evaluation showed elevated blood liver enzymes, ammonia, citrulline....
Sir, Cerebral venous sinus thrombosis (CVST) is a subtype of stroke with extremely varied clinical presentations and imaging findings, it has good outcomes in the majority. The annual incidence CVST approximately 2–5 cases per million year population.[1] It typically occurs young adults.[2] been reported that up to 44.3% patients may have seizures early stage disease, 9.5% late seizures.[3] Seizures secondary are categorized into early/acute symptomatic (within 14 days after diagnosis)...
Neurocutaneous melanocytosis (NCM) is a rare, sporadic neuroectodermal dysplasia characterized by the presence of large or multiple congenital cutaneous nevi and melanocytic deposits in central nervous system. Hitherto, unreported we describe case NCM with optic neuropathy spinal cord melanoma from India. A 20 year-old-lady had headache vomiting for 3 months followed consecutive profound painless visual impairment. Visual acuity was counting fingers at 1 m distance both eyes normal fundus....
Waldenstroms macroglobulinemia (WM) is a low-grade B cell neoplasm. Bing Neel syndrome rare manifestation of WM characterized by infiltrative involvement the central nervous system. 64-year-old man, presented with 4 years history slowly progressive diplopia and ptosis eyes. Examination showed left oculomotor (internal external ophthalmoplegia), trochlear, abducens, right partial abducens nerve involvement. Evaluation anemia hemoglobin 10.7 g/dl, raised erythrocyte sedimentation rate 120 mm/h...
Purpose Workflow optimisation is crucial for establishing a viable acute stroke (AS) intervention programme in large tertiary care centre. This study aims to utilise Lean Six Sigma (LSS) principles enhance the hospital's workflow. Design/methodology/approach The Action Research methodology was used implement project and develop case study. took place academic hospital India. Define-Measure-Analyse-Improve-Control approach optimised workflow within 6 months. tools such as value stream mapping...
Abstract Pain is an important manifestation of Parkinson’s Disease, with multiple mechanisms independently contributing to it. Here, we describe a case predominant nociplastic pain. A 62-year-old woman advanced disease motor fluctuations presented 6-month history incapacitating She described it as burning sensation and tightness in her body, including the face, throat, perineum. The pain precipitated when dopaminergic drugs wore off, lasting for 1–2 hours. Diagnosis was considered, she...
Background Anti-CD20 monoclonal antibodies have received increasing attention in the past few years treatment of multiple sclerosis (MS). Objectives This study describes (i) efficacy and safety rituximab people living with MS (ii) assesses clinical imaging outcomes following Method is a chart review from registry maintained at institute University Hospital South India. Result Eighty-three (M:F, 26:57) as immunomodulation between 2007 2022 median follow-up duration 18 months. Fifty-nine (71%)...
Dasari, Nikitha; Mundlamuri, Ravindranadh Chowdary; Vengaleel, Seena; Raja, Pritam; Yadav, Ravi; Sadashiva, Nishanth; Karthick, K; Nandeesh, BN; Atchayaram, Nalini Author Information
Abstract Background and Objectives: Early initiation maintenance of anticoagulation appears to be the mainstay treatment cerebral venous thrombosis (CVT), but evidence supporting intensity duration is limited. Methods: We retrospectively collected data patients admitted with CVT over a 5-year period, who had minimum 6 months clinical follow-up three or more prothrombin time international normalized ratio (INR) values spread months. Data included demographic, clinical, radiologic parameters,...
We aim to provide a pictorial representation of the broad spectrum intracranial hemorrhages associated with cerebral venous thrombosis (CVT), emphasizing atypical locations and rare intracerebral hemorrhage (ICH) types. also hypothesize pathophysiology leading ICH in CVT outcomes anticoagulation therapy.
Early mortality in intracerebral hemorrhage (ICH) is due to hematoma volume (HV) expansion, and there are no effective treatments available other than reduction blood pressure. Tranexamic acid (TXA) a hemostatic drug that widely safe can be cost-effective treatment for ICH, if proven efficacious. Administration of TXA ICH patients when given within 4.5 h symptom onset will reduce early at 30 days. Indian Trial Spontaneous Intracerebral Haemorrhage (INTRINSIC trial) multicenter, randomized,...
Abstract Background: Glutaric aciduria type-1 (GA-1) is a rare metabolic disorder due to mutation in GCDH gene resulting varied clinical manifestations. Here we report case of adult-onset GA-1 with acute myelo-neuropathy and chronic renal failure. Institutional ethics committee approval was obtained genetic analysis done by exome sequencing. Case presentation: A 19 year-old-man 2 years history disease presented 5 months sudden onset weakness proximal distal lower limbs bladder retention....