A5011876376- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Physiological and biochemical adaptations
- Genetic factors in colorectal cancer
- Genetics, Bioinformatics, and Biomedical Research
- Insect Utilization and Effects
- Andrographolide Research and Applications
- Cancer and biochemical research
- Renal cell carcinoma treatment
- Aquaculture disease management and microbiota
- Heat shock proteins research
- Agriculture, Soil, Plant Science
- Drug-Induced Hepatotoxicity and Protection
- Cellular transport and secretion
- Digestive system and related health
- Pharmacovigilance and Adverse Drug Reactions
- Computational Drug Discovery Methods
- Cancer Immunotherapy and Biomarkers
- Retinal Development and Disorders
- Genomics and Phylogenetic Studies
- Genetics, Aging, and Longevity in Model Organisms
- Immune Cell Function and Interaction
- Regional Development and Management Studies
- Berberine and alkaloids research
- Neurological disorders and treatments
National Institute of Mental Health and Neurosciences
2021-2025
University of Calcutta
2022-2025
Central Inland Fisheries Research Institute
2022
Mizoram University
2015-2020
KIIT University
2016
Renal cell carcinoma (RCC) is the one of most fatal and frequent form urological malignancy worldwide. The von Hippel-Lindau (VHL) tumour suppressor gene a critical component VHL-Cullin2-ElonginB/C (VCB) complex that regulates ubiquitin-mediated proteasomal degradation proteins with mutations consistently associated development clear renal (ccRCC). Despite extensive investigations conducted worldwide, there notable lack data concerning VHL in sporadic ccRCC patients from India. Our study...
Gastric cancer has emerged as a key challenge in oncology research malignant tumour with advanced stage detection. Apart from surgical management, pharmacotherapeutic approach to stomach treatment is an appealing option consider. Andrographolide been shown have anticancer and chemosensitizer properties variety of solid tumors, including but the exact molecular mechanism skeptical. In this study, we identified validated pharmacological involved GC integrated network pharmacology docking. The...
The aim of this study was to evaluate the risk gastric cancer associated with individual or combined glutathione S-transferases (GSTs) polymorphism and their interaction environmental factors.Genotyping by PCR carried out for 80 cases controls each GSTM1, GSTT1, GSTP1 mapped gene-environment association studies. samples were subjected pathogen detection expression analyzing different genotypes. Logistic regression analyses conducted compute influence both genetic factors cancer. MDR analysis...
PI3K/AKT/mTOR pathway is one of the frequently disrupted signaling pathways in renal cell carcinoma (RCC) that plays a significant role tumor formation, disease progression and therapeutic resistance. Therefore, novel natural molecules targeting critical proteins this will provide best alternative to existing drugs, which are toxic develops Recent studies have recognized anti-cancer potential mycocompounds. The current study focused on screening various mycocompounds from Astraeus...
One of the most fatal urological malignancies is clear cell renal carcinoma (ccRCC), yet little known about its pathophysiology or prognosis. This study aimed at obtaining some novel biomarkers with diagnostic and prognostic meaning may find out potential therapeutic targets for ccRCC.
Background:: Mutations in the CDH1 and role of E-cadherin proteins are well established gastric cancer. Several silico tools available to predict pathogenicity mutations present genes with varying efficiency sensitivity detect mutations. Objective:: Our objective was identify somatic pathogenic variants involved Gastric Cancer (GC) by Sanger sequencing as using find out best efficient tool for prediction missense variants. Methods:: done 80 GC tumor adjacent normal tissues. Synthetic data...
INTRODUCTION: Dystonia is one of the most common hyperkinetic movement disorders observed in children with neurological disorders. The objective this study was to evaluate demographic, etiological, and radiological profile childhood dystonia. METHODS: This a retrospective chart review dystonia (onset ≤18 years) who were admitted our hospital from 2013 2017. All relevant demographic data including ethnicity, socioeconomic cultural background, examination findings, electrophysiological, other...
Multiple studies have suggested that subjects with glutathione S-transferase P1 (GSTP1)-mutations are at high risk for urinary bladder cancer (UBC). In the present study, we evaluated mutations in GSTP1 and mitochondrial D-loop genes two unrelated familial patients belonging to Karbi Anglong Assam tribe. Mitochondrial nuclear polymorphic region were amplified sequenced all family members patients. Two SNPs gene amino acid substitutions codons 105 (Ile→Val) 114 (Val→Ala) genotyped by...
Adverse drug reactions, often known as ADRs, are a significant concern in clinical medicine that can have an effect on both the safety of patients and outcomes their healthcare. processes, methods detection, preventative measures associated with adverse reactions (ADRs). Among most important subjects various molecular mechanisms responsible for These include pharmacokinetic aspects including metabolism excretion, well pharmacodynamic interactions at cellular levels. In realm detection...
Through the use of immune system to combat cancer, cancer immunotherapy has brought new hope patients and transformed discipline oncology. Immune checkpoint inhibitors, CAR T-cell therapy, vaccines are just a few treatment approaches that have emerged thanks recent advancements; these demonstrated remarkable effectiveness in variety types. schools thought immunotherapy, focusing on its action mechanisms, therapeutic uses, most current innovations. We talk about combination treatments try...