A5024691298- Inflammatory Bowel Disease
- Microscopic Colitis
- Glycosylation and Glycoproteins Research
- Eosinophilic Esophagitis
- Pregnancy and Medication Impact
- Endometriosis Research and Treatment
- Celiac Disease Research and Management
- Autoimmune and Inflammatory Disorders
- Monoclonal and Polyclonal Antibodies Research
- Carbohydrate Chemistry and Synthesis
- Immunodeficiency and Autoimmune Disorders
- Axon Guidance and Neuronal Signaling
- Reproductive System and Pregnancy
- Proteoglycans and glycosaminoglycans research
- Adolescent and Pediatric Healthcare
- Galectins and Cancer Biology
- Viral Infectious Diseases and Gene Expression in Insects
- Metabolism, Diabetes, and Cancer
- Biofuel production and bioconversion
- Clostridium difficile and Clostridium perfringens research
- Sexual function and dysfunction studies
- Peptidase Inhibition and Analysis
- Transgenic Plants and Applications
- Fluoride Effects and Removal
- Autoimmune and Inflammatory Disorders Research
University of Georgia
2013-2024
Rhode Island Hospital
2013-2019
Providence College
2013-2018
Hasbro Children's Hospital
2015-2016
Park University
2014
Grupo Lederval (Spain)
2014
Brown University
2010-2011
Lifespan
2010-2011
Icahn School of Medicine at Mount Sinai
2010-2011
Massachusetts General Hospital
2010
Summary Xylan is the third most abundant glycopolymer on earth after cellulose and chitin. As a major component of wood, grain forage, this natural biopolymer has far‐reaching impacts human life. This highly acetylated cell wall polysaccharide vital plant wall, which functions as molecular scaffold, providing plants with mechanical strength flexibility. Mutations that impair synthesis xylan backbone give rise to fail grow normally because collapsed xylem cells in vascular system. Phenotypic...
Summary Background Fatigue is common in Crohn's disease ( CD ) and ulcerative colitis UC ). Data on fatigue newly diagnosed patients are unavailable. Aim To report prevalence of examine its association with health‐related quality life HRQOL ), depression disability. Methods The Ocean State Colitis Area Registry OSCCAR a statewide cohort inflammatory bowel Rhode Island. was assessed using the Functional Assessment Chronic Illness Therapy‐Fatigue Scale. Patients were administered instruments...
Glycan structures on glycoproteins and glycolipids play critical roles in biological recognition, targeting, modulation of functions animal systems. Many classes glycan are capped with terminal sialic acid residues, which contribute to by either forming or masking recognition sites the cell surface secreted glycoconjugates. Sialylated glycans synthesized mammals a single conserved family sialyltransferases that have diverse linkage acceptor specificities. We examined enzymatic basis for...
The art of producing recombinant proteins with complex post-translational modifications represents a major challenge for studies structure and function. rapid establishment high recovery from transiently-transfected mammalian cell lines addresses this barrier is an effective means expressing that are naturally channeled through the ER Golgi-mediated secretory pathway. Here one protocol protein expression using human HEK293F HEK293S transfected vector designed yields. applicability system...
Congenital diaphragmatic hernia (CDH) is a common birth malformation with heterogeneous etiology. In this study, we report that ablation of the heparan sulfate biosynthetic enzyme NDST1 in murine endothelium (Ndst1ECKO mice) disrupted vascular development diaphragm, which led to hypoxia as well subsequent diaphragm hypoplasia and CDH. Intriguingly, phenotypes displayed Ndst1ECKO mice resembled developmental defects observed slit homolog 3 (Slit3) knockout mice. Furthermore, introduction...
Interaction of transmembrane receptors the Robo family and secreted protein Slit provides important signals in development central nervous system regulation axonal midline crossing. Heparan sulfate, a sulfated linear polysaccharide modified complex variety ways, serves as an essential co-receptor Slit-Robo signaling. Previous studies have shown that closely related heparin octasaccharides bind to Drosophila directly, surface plasmon resonance analysis revealed Robo1 binds more tightly...
The effect of the inflammatory bowel diseases (IBD) on menstrual function is largely unknown. aims this study were to determine whether changes in occur year before IBD diagnosis or initial years after diagnosis. Women aged 18 and older Ocean State Crohn's Colitis Area Registry with at least 2 follow-up eligible for study. All patients enrolled within 6 months followed prospectively. Menstrual cycle characteristics retrospectively assessed. To assess over time, general linear models...
Despite the fact that inflammatory bowel diseases (IBD) and their treatments may affect physical appearance, effect of IBD on body image is poorly understood. The aims this study were to determine whether dissatisfaction (BID) changes over time in patients with examine demographic disease-related variables associated decreased image. Adults aged 18 above Ocean State Crohn's Colitis Area Registry at least 2 years follow-up eligible for study. All enrolled within 6 months diagnosis followed...
Abstract Background and Aims Cross-sectional studies on sexual function in men with inflammatory bowel disease (IBD) yield mixed results. Using a prospective incidence cohort, we aimed to describe at baseline over time identify factors associated impaired IBD. Methods Men 18 years older enrolled between April 2008 January 2013 the Ocean State Crohn’s Colitis Area Registry (OSCCAR) minimum of 2 follow-up were eligible for study. Male was assessed using International Index Erectile Function...
The literature provides conflicting data on sexual function in women with inflammatory bowel disease (IBD). We aim to describe at baseline and over time a prospective inception cohort of adult IBD. Women age 18 years or older enrolled the Ocean State Crohn's & Colitis Area Registry (OSCCAR) 2 follow-up were included study. All subjects within 1 year IBD diagnosis. Female was assessed using Sexual Function Index (FSFI). Linear mixed effects models used assess changes FSFI by various...
Studies describing the incidence of Crohn's disease (CD) and ulcerative colitis (UC) are uncommon in United States. We sought to determine CD UC state Rhode Island. The Ocean State Colitis Area Registry is a state-based inception cohort patients newly diagnosed with inflammatory bowel (IBD) To confirm diagnosis CD, UC, or IBD unclassified (IBDU), National Institute Diabetes Digestive Kidney Diseases Genetics Consortium criteria were applied review medical records from gastroenterology...
Crohn's disease (CD) is a form of inflammatory bowel with different described behaviors, including stricture. At present, there are no laboratory studies that can differentiate stricturing CD from other phenotypes disease. We performed pilot study to examine differences in the proteome among patients CD, nonstricturing and ulcerative colitis. Serum samples were selected Ocean State Colitis Area Registry, an established cohort Patients surgically resected stricture matched similar without...
The art of producing recombinant proteins with complex post-translational modifications represents a major challenge for studies structure and function. rapid establishment high recovery from transiently-transfected mammalian cell lines addresses this barrier is an effective means expressing that are naturally channeled through the ER Golgi-mediated secretory pathway. Here one protocol protein expression using human HEK293F HEK293S transfected vector designed yields. applicability system...
The incidence of Clostridium difficile infection (CDI) in inflammatory bowel disease (IBD) is increasing, and CDI has a negative impact on IBD outcomes with both increased morbidity mortality. Data are lacking regarding the rate appropriate testing for at time diagnosis. We sought to determine positivity diagnosis using data collected through Ocean State Crohn's Colitis Area Registry (OSCCAR), prospective cohort patients newly diagnosed IBD. were determined by reviewing medical records...
The impact of dietary behaviors on health outcomes in youth with inflammatory bowel disease (IBD) is unclear. present study examined and their association biomedical factors IBD. Eighty-six newly diagnosed (mean age = 12.6) were included analyses. Biomedical activity markers. Despite adequate total caloric intake, estimated nutrient fruit vegetable intakes below recommended levels. There was a significant negative between intake C-Reactive Protein (p 0.04). Results suggest that play an...
Background: Traditional cohort studies are important contributors to our understanding of inflammatory bowel diseases, but they labor intensive and often do not focus on patient-reported outcomes. Internet-based provide new opportunities study outcomes can be efficiently implemented scaled. If a traditional was linked an study, both could benefit from added synergy. Existing opportunity develop test processes for linkage. The Crohn’s Colitis Foundation America’s (CCFA) Partners is more than...
An erratum was issued for: High Yield Expression of Recombinant Human Proteins with the Transient Transfection HEK293 Cells in Suspension. The Authors section updated. from: