A5056403300- Nonlinear Dynamics and Pattern Formation
- Ecosystem dynamics and resilience
- Cancer Cells and Metastasis
- Cellular Mechanics and Interactions
- Ecology and Vegetation Dynamics Studies
- Evolutionary Game Theory and Cooperation
- Opinion Dynamics and Social Influence
- Single-cell and spatial transcriptomics
- Complex Network Analysis Techniques
- Stochastic processes and statistical mechanics
- Neural dynamics and brain function
- Biocrusts and Microbial Ecology
- Cancer-related molecular mechanisms research
- Congenital heart defects research
- Salivary Gland Disorders and Functions
- stochastic dynamics and bifurcation
- Liquid Crystal Research Advancements
- 3D Printing in Biomedical Research
- Pluripotent Stem Cells Research
- Cardiac Valve Diseases and Treatments
- Cancer Genomics and Diagnostics
- Photoreceptor and optogenetics research
- Cutaneous Melanoma Detection and Management
- Hippo pathway signaling and YAP/TAZ
- Liver physiology and pathology
The Gurdon Institute
2020-2025
University of Cambridge
2020-2025
University of Chile
2015-2025
Wellcome Trust
2020-2024
Imperial College London
2017-2020
King's College London
2020
University of Concepción
2013-2014
Significance Understanding how intracellular signaling cascades control cell fate is a key issue in stem biology. Here we show that exit from the compartment mammalian epidermis characterized by pulsatile ERK MAPK activity. Basal activity and pulses are differentially regulated DUSP10 DUSP6, two phosphatases have been shown previously to regulate differentiation commitment epidermis. controlled both transcriptionally posttranscriptionally. Spatial segregation of mean observed reconstituted...
Desertification due to climate change and increasing drought periods is a worldwide problem for both ecology economy. Our ability understand how vegetation manages survive propagate through arid semiarid ecosystems may be useful in the development of future strategies prevent desertification, preserve flora-and fauna within-or even make use scarce resources soils. In this paper, we study robust phenomena observed semi-arid ecosystems, by which localized patches split process called...
The development of the mouse salivary gland involves a tip-driven process branching morphogenesis that takes place in concert with differentiation into acinar, myoepithelial, and ductal (basal luminal) sub-lineages. By combining clonal lineage tracing three-dimensional (3D) reconstruction branched epithelial network single-cell RNA-seq analysis, we show tips, heterogeneous population renewing progenitors transition from Krt14+ multipotent state to unipotent states via two transcriptionally...
Spatial branching processes are ubiquitous in nature, yet the mechanisms that drive their growth may vary significantly from one system to another. In soft matter physics, chiral nematic liquid crystals provide a controlled setting study emergence and dynamic of disordered patterns. Via an appropriate forcing, cholesteric phase nucleate crystal, which self-organizes into extended pattern. It is known events take place when rounded tips fingers swell, become unstable, split two new tips. The...
In this paper, a comprehensive spatio-spectral and temporal analysis for Chromobacterium violaceum colonies is reported. A hyperspectral imaging (HSI) system used to recover the spectral signatures of pigment production in non-homogeneous media with high resolution sensitivity vivo, without destructing sample. This non-contact sensing technique opens avenues study growing specific section bacterial colony. Further, from 580 [nm] 764 time series, wild-type mutant strains are characterized....
Abstract The mechanisms that regulate the patterning of branched epithelia remain a subject long-standing debate. Recently, it has been proposed statistical organization multiple ductal tissues can be explained through local self-organizing principle based on branching-annihilating random walk (BARW) in which proliferating tips drive process elongation and stochastic bifurcation terminates when encounter maturing ducts. Here, applied to mouse salivary gland, we show BARW model struggles...
Stationary two-dimensional localized structures have been observed in a wide variety of dissipative systems. The existence, stability properties, dynamical evolution, and bifurcation diagram an azimuthal symmetry breaking, rodlike structure the isotropic prototype model pattern formation, Swift-Hohenberg model, is studied. These persist under presence nongradient perturbations. Interaction properties are This allows us to envisage possibility different crystal-like configurations.
Abstract Branching processes are used to model diverse social and physical scenarios, from extinction of family names nuclear fission. However, for a better description natural phenomena, such as viral epidemics in cellular tissues, animal populations networks, spatial embedding—the branching random walk (BRW)—is required. Despite its wide range applications, the properties volume explored by BRW so far remained elusive, with exact results limited one dimension. Here we present analytical...
A wide range of physical systems exhibit labyrinthine patterns as transient or steady states. One the routes by which labyrinths emerge is through destabilization a localized structure curvature instability. In this work, we will study emergence mechanism in different contexts, including nonlinear cavity optics, vegetation dynamics and chemical reactions. Furthermore, it shown that resulting can be classified depending on their connectivities.
In this work, we investigate the dynamics of complex networks FitzHugh-Nagumo excitable oscillators, focusing on impact coupling strength, network size, and randomness their collective dynamics. Considering Watts-Strogatz small-world connectivities, system exhibits three distinct dynamical phases: chaotic, intermittent, synchronized, with intermittent phase displaying transient, epileptic-like chimera states. We analyse transition to synchronisation by means master stability function, show...
Abstract Fluctuation in signal transduction pathways is frequently observed during mammalian development. However, its role regulating stem cells has not been explored. Here we tracked spatiotemporal ERK MAPK dynamics human epidermal cells. While and differentiated were distinguished by high low stable basal activity, respectively, also found with pulsatile activity. Transitions from Basal hi -Pulse lo (stem) to , mid (differentiated) occurred expanding keratinocyte colonies response a range...
One of the key characteristics multicellular organisms is ability to establish and maintain shapes, or morphologies, under a variety physical chemical perturbations. A quantitative description underlying morphological dynamics critical step fully understand self-organising properties systems. Although many powerful mathematical tools have been developed analyse stochastic dynamics, rarely these are applied experimental developmental biology. Here, we take root tip regeneration in plant model...
Congenital heart malformations often include mitral valve defects which remain largely unexplained. During embryogenesis, a restricted population of endocardial cells within the atrioventricular canal (AVC) undergoes endothelial to mesenchymal transition (EndMT) give rise valvular cells. However, identity, fate decisions these progenitors as well distribution their derivatives in leaflets unknown. Here, we use scRNA-seq genetically labeled mouse AVC and micro-dissected embryonic postnatal...
The stability of a circular localized spot with respect to azimuthal perturbations is studied in variational Swift-Hohenberg model equation. conditions under which the shape undergoes an elliptical deformation that transform it into rod structure are analyzed. As elongates rod-like exhibits transversal instability generates invaginated labyrinth invades all space available.
The study of diffusion in a crowded and complex environment, such as inside cell or within porous medium, is fundamental importance for science technology. Combining blinking holographic optical tweezers sub-pixel video microscopy permits one to Brownian motion confined geometries. In this work, particular, we have studied the two colloidal particles interacting hydrodynamically with each other. proximity between microspheres induces space-dependence coefficient and, therefore, <i>a spurious...