Guowei Chen

ORCID: 0000-0002-1071-4993
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About
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Research Areas
  • Bacteriophages and microbial interactions
  • Plant Virus Research Studies
  • Plant and Fungal Interactions Research
  • Topic Modeling
  • Natural Language Processing Techniques
  • Supply Chain Resilience and Risk Management
  • RNA and protein synthesis mechanisms
  • Sentiment Analysis and Opinion Mining
  • Quantum Computing Algorithms and Architecture
  • Landslides and related hazards
  • Viral gastroenteritis research and epidemiology
  • RNA modifications and cancer
  • Advanced Computational Techniques and Applications
  • CRISPR and Genetic Engineering
  • Quantum Mechanics and Applications
  • Cryospheric studies and observations
  • Quantum Information and Cryptography
  • Multimodal Machine Learning Applications
  • RNA Research and Splicing
  • Service-Oriented Architecture and Web Services
  • Climate change and permafrost

City University of Hong Kong
2022-2024

Shanghai Jiao Tong University
2021

Communication University of China
2021

Huaiyin Institute of Technology
2019

Huazhong University of Science and Technology
2019

University of Alaska Fairbanks
2013

Zhejiang Gongshang University
2010

Abstract Here, we presented an integrative database named DrLLPS (http://llps.biocuckoo.cn/) for proteins involved in liquid–liquid phase separation (LLPS), which is a ubiquitous and crucial mechanism spatiotemporal organization of various biochemical reactions, by creating membraneless organelles (MLOs) eukaryotic cells. From the literature, manually collected 150 scaffold that are drivers LLPS, 987 regulators contribute modulating 8148 potential client might be dispensable formation MLOs,...

10.1093/nar/gkz1027 article EN cc-by-nc Nucleic Acids Research 2019-10-21

Without relying on cultivation, metagenomic sequencing greatly accelerated the novel RNA virus detection. However, it is not trivial to accurately identify viral contigs from a mixture of species. The low content viruses in data requires highly specific detector, while new can exhibit high genetic diversity, posing challenge for alignment-based tools. In this work, we developed VirBot, simple yet effective identification tool based protein families and corresponding adaptive score cutoffs....

10.1093/bioinformatics/btad093 article EN cc-by Bioinformatics 2023-02-16

Improved RNA virus understanding is critical to studying animal and plant health, environmental processes. However, the continuous rapid evolution makes their identification characterization challenging. While recent sequence-based advances have led extensive discovery, there growing variation in how viruses are identified, analyzed, characterized, reported. To this end, an RdRp Summit was organized a hybrid meeting took place Valencia, Spain May 2023 convene leading experts with emphasis on...

10.3389/fviro.2024.1371958 article EN cc-by Frontiers in Virology 2024-04-04

Abstract Background The high-throughput sequencing technologies have revolutionized the identification of novel RNA viruses. Given that viruses are infectious agents, identifying hosts these new carries significant implications for public health and provides valuable insights into dynamics microbiome. However, determining newly discovered is not always straightforward, especially in case detected environmental samples. Even host-associated samples, it correct to assign sample origin as host...

10.1093/gigascience/giae059 article EN cc-by GigaScience 2024-01-01

Research Article| February 01, 2013 Site Investigation and Slope Stability Analysis of the Chitina Dump Slide (CDS), Alaska KYLE E OBERMILLER; OBERMILLER 1 University Fairbanks, P.O. Box 755800, AK 99775-5800 1Corresponding author email: kobermiller@golder.com Search for other works by this on: GSW Google Scholar MARGARET M DARROW; DARROW SCOTT L HUANG; HUANG GANG CHEN Author Article Information Publisher: Association Environmental & Engineering Geologists First Online: 02 Mar 2017 Online...

10.2113/gseegeosci.19.1.27 article EN Environmental and Engineering Geoscience 2013-02-01

Viruses are the most abundant form of life on earth and play important roles in a broad range ecosystems. Currently, two methods, whole genome shotgun metagenome (WGSM) viral-like particle enriched (VLPM) sequencing, widely applied to compare viruses various environments. However, there is no critical assessment their performance recovering biological interpretation comparative viral metagenomic studies. To fill this gap, we methods investigate stool virome hepatocellular carcinoma (HCC)...

10.3390/v15010053 article EN cc-by Viruses 2022-12-24

Abstract RNA viruses exhibit vast phylogenetic diversity and can significantly impact public health agriculture. However, current bioinformatics tools for viral discovery from metagenomic data frequently generate false positive virus results, overestimate diversity, misclassify sequences. Additionally, often fail to determine virus-host associations, which hampers investigation of the potential threat posed by a newly detected virus. To address these issues we developed VirID, software tool...

10.1101/2024.07.05.602175 preprint EN cc-by bioRxiv (Cold Spring Harbor Laboratory) 2024-07-09

Segmented RNA viruses are a complex group of with multisegment genomes. Reconstructing complete segmented is crucial for advancing our understanding viral diversity, evolution, and public health impact. Using metatranscriptomic data to identify known novel has sped up the survey in various ecosystems. However, high genetic diversity difficulty binning genomes present significant challenges virus reconstruction. Current detection tools primarily used nonsegmented This study presents SegVir,...

10.1093/molbev/msae171 article EN cc-by Molecular Biology and Evolution 2024-08-01

Abstract RNA viruses exhibit vast phylogenetic diversity and can significantly impact public health agriculture. However, current bioinformatics tools for viral discovery from metagenomic data frequently generate false positive virus results, overestimate diversity, misclassify sequences. Additionally, often fail to determine virus–host associations, which hampers investigation of the potential threat posed by a newly detected virus. To address these issues we developed VirID, software tool...

10.1093/molbev/msae202 article EN cc-by-nc Molecular Biology and Evolution 2024-09-27

Reverse dictionary(RD) is to map a description or definition name of concept. Most the existing reverse dictionary methods are word-based, failing handle polysemy words. In this paper, we propose Non-Ambiguous Dictionary(NARD), synset-based model using synset embeddings replace word embeddings. NARD provides different and effective for senses in multi-sense words, allowing more convergent mapping words descriptive sentences at semantic level. With cross-dictionary sense tagging, can utilize...

10.1109/ictai52525.2021.00176 article EN 2021 IEEE 33rd International Conference on Tools with Artificial Intelligence (ICTAI) 2021-11-01

The number of inequivalent classes 10-qubit graph states is 3132. All 3132 local graphs are classified as two categories: with equal bound, unequal bounds. We will use different methods to calculate the entanglement ten qubits for categories. For bounds, closest product given, and they have structural characters.

10.1109/icnc.2010.5583975 article EN 2010 Sixth International Conference on Natural Computation 2010-08-01

The laboratory is an important base for experimental teaching, scientific research and technical services in colleges universities, one of the basic conditions running a good school. In response to repeated setting teaching resources construction management university laboratories, lack sharing resources, occlusion information, I have improved designed IE <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> dynamic website.This paper adopts...

10.1109/iciase45644.2019.9074054 article EN 2019-04-01
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