A5089440042- Plant Virus Research Studies
- Bacteriophages and microbial interactions
- Plant and Fungal Interactions Research
- Animal Virus Infections Studies
- Viral Infections and Vectors
- Viral gastroenteritis research and epidemiology
- Plant Disease Resistance and Genetics
- Genomics and Phylogenetic Studies
- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- Animal Disease Management and Epidemiology
Taronga Conservation Society Australia
2022-2024
The University of Sydney
2021-2024
Despite a rapid expansion in the number of documented viruses following advent metagenomic sequencing, identification and annotation highly divergent RNA remain challenging, particularly from poorly characterized hosts environmental samples. Protein structures are more conserved than primary sequence data, such that structure-based comparisons provide an opportunity to reveal viral 'dusk matter': sequences with low, but detectable, levels identity known available protein structures. Here, we...
Australia is home to a diverse range of unique native fauna and flora. To address whether Australian ecosystems also harbour viruses, we performed meta-transcriptomic sequencing 16 farmland sediment samples taken from the east west coasts Australia. We identified 2460 putatively novel RNA viruses across 18 orders, vast majority which belonged microbe-associated phylum Lenarviricota. In many such as Nodamuvirales Ghabrivirales, here comprised entirely new clades. Novel fell between...
Improved RNA virus understanding is critical to studying animal and plant health, environmental processes. However, the continuous rapid evolution makes their identification characterization challenging. While recent sequence-based advances have led extensive discovery, there growing variation in how viruses are identified, analyzed, characterized, reported. To this end, an RdRp Summit was organized a hybrid meeting took place Valencia, Spain May 2023 convene leading experts with emphasis on...
Abstract The RNA virus phylum Lenarviricota is composed of the fungi-associated families Narnaviridae and Mitoviridae, bacteriophage Leviviridae, plant Botourmiaviridae. Members are abundant in most environments boast remarkable phylogenetic genomic diversity. As this includes both fungi- plant-associated species, likely mark a major evolutionary transition between those viruses associated with prokaryotes eukaryotes. Despite expansion following metagenomic studies, relationships among...
Viruses impose a substantial disease burden on dogs and the close relationship between humans may facilitate zoonotic emergence. Australia's geographic isolation, strict biosecurity measures native dingo populations present unique model for understanding spread evolution of canine viruses. However, aside from few well–characterised pathogens, genomic data are scarce many common dog viruses, limiting our their ecology. Using metatranscriptomic approach we identified viruses in dingoes various...
The RNA virus family Picobirnaviridae has traditionally been associated with the gastrointestinal systems of terrestrial mammals and birds, majority viruses detected in animal stool samples. Metatranscriptomic studies vertebrates, invertebrates, microbial communities, environmental samples have resulted an enormous expansion genomic phylogenetic diversity this family. Yet picobirnaviruses remain poorly classified, only one genus three species formally ratified by International Committee...
Little is known about the diversity of RNA viruses in geothermal systems. We generated total sequencing data from two hot springs Kuirau Park, Rotorua, New Zealand. In one set, a 71.8 °C pool, we observed microbial community that was 98.5% archaea. The second representing cooler 36.8 spring, had more diverse profile: 58% bacteria, 34.5% eukaryotes and 7.5% Within this latter detected sequences likely 23 families Astroviridae, Tombusviridae, Polycipiviridae, Discistroviridae, Partitiviridae,...
ABSTRACT The RNA virus family Picobirnaviridae has traditionally been associated with the gastrointestinal systems of terrestrial mammals and birds, majority viruses detected in animal stool samples. Metatranscriptomic studies vertebrates, invertebrates, microbial communities, environmental samples have resulted an enormous expansion genomic phylogenetic diversity this family. Yet picobirnaviruses remain poorly classified, only one genus three species formally ratified by International...
Despite the remarkable diversity of RNA viruses, little is known about how physical and biotic properties local environments impact virome compositions. Utilizing an expansive metatranscriptomic data set from 32 different geographic environments, we identified 2,683 novel viruses soil, sediment, animal faecal samples, greatly increasing phylogenetic virosphere. Sediments faeces were particularly rich sources viruses. Environmental factors had a greater on abundance virus families with plant,...
ABSTRACT Despite a rapid expansion in the number of known RNA viruses following advent metagenomic sequencing, identification and annotation highly divergent remains challenging, particularly from poorly characterized hosts environmental samples. Protein structures are more conserved than primary sequence data, such that structure-based comparisons provide an opportunity to reveal viral “dusk matter”: sequences with low, but detectable, levels identity available protein structures. Here, we...
ABSTRACT Australia is home to a diverse range of unique native fauna and flora. To address whether Australian ecosystems also harbour viruses, we performed meta-transcriptomic sequencing 16 farmland sediment samples taken from the east west coasts Australia. We identified 2,562 putatively novel viruses across 15 orders, vast majority which belonged microbe-associated phylum Lenarviricota . In many here comprised entirely new clades, such as Nodamuvirales Ghabrivirales Novel fell between...