A5018037820- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Inflammatory Bowel Disease
- Microscopic Colitis
- Gut microbiota and health
- Colorectal Cancer Treatments and Studies
- Helicobacter pylori-related gastroenterology studies
- Child Nutrition and Feeding Issues
- Digestive system and related health
- Metastasis and carcinoma case studies
- Autism Spectrum Disorder Research
- Bioinformatics and Genomic Networks
- Genetics, Bioinformatics, and Biomedical Research
- Psychotherapy Techniques and Applications
- Gastrointestinal motility and disorders
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal Tumor Research and Treatment
- Immune Cell Function and Interaction
- Diet and metabolism studies
- Biomedical Ethics and Regulation
- Olfactory and Sensory Function Studies
- Machine Learning in Bioinformatics
- Liver Diseases and Immunity
- Abdominal Surgery and Complications
University of Oslo
1987-2019
Akershus University Hospital
2019
Cancer Registry of Norway
1999
Oslo University Hospital
1982-1997
Lillestrøm Centre of Expertise
1992
Med-Storm Innovation (Norway)
1982-1991
Drammen Hospital
1987
Rigshospitalet
1987
Telemark Hospital
1987
Institutt for Eksperimentell Medisinsk Forskning
1985
There is an unexplained association between ulcerative colitis [UC] and primary sclerosing cholangitis [PSC], with the intestinal microbiota implicated as important factor. The study aim was to compare structure of patients UC without PSC. PSC [PSC-UC] were identified from biobanks at Oslo University Hospital, Foothills Hospital Calgary Mount Sinai Toronto. Microbial DNA extracted colonic tissue sequencing performed V4 region 16S rRNA gene on Illumina MiSeq. Sequences assigned operational...
Imbalance in the microbiota, dysbiosis, has been identified inflammatory bowel disease (IBD). We explored fecal microbiota pediatric patients with treatment-naïve IBD, non-IBD gastrointestinal symptoms and healthy children, its relation to IBD subgroups, treatment outcomes.Fecal samples were collected from 235 children below 18 years of age. Eighty had Crohn's (CD), 27 ulcerative colitis (UC), 3 unclassified, 50 symptomatic patients, 75 healthy. The bacterial abundance 54 predefined DNA...
A prospective endoscopic screening examination of a randomized population sample 200 men and women, aged 50–59 years, enabled the differentiation between individuals with without polyps in rectum sigmoid colon. Both number years smoking percentage life were associated presence adenomas hyperplastic polyps, both for women. No relationship was found these factors or daily cigarettes degree dysplasia size multiplicity polyps. Two years' follow-up showed tendency to fewer new among male...
In this case-control study we compared dietary habits among 108 patients with small (≤ 5 mm, n = 26), medium (5–9 48) or large (≥ 10 34) colorectal polyps 35 healthy age- and gender-matched controls. A food record by weighing during consecutive days was performed. The intake of fat significantly higher the patients, in contrast to a lower carbohydrate, fibre iron, vitamin C calcium shown be but significant only for women. There tendency consume lower-antioxidant, cereal diet, calcium-rich...
One hundred and sixteen patients were included, during 18 months, in a double-blind placebo-controlled intervention study, with calcium, vitamins A, C, E selenium (in cocktail) or placebo against growth of colonic polyps. Patients randomized within three arms, according to diameter the largest polyp, < 5 mm, 5–9 mm > 9 mm. Polyps resected, others left be measured annually before resection after 3 years. The protocol (performed all patients) included registration demographic data, family...
Two-dimensional protein maps of biopsies from normal mucosa, tubular adenomas (polyps), and colonic carcinomas in humans have been studied order to obtain information on the possible precancerous role intestinal polyps. The are complex several hundred spots seen after staining with Coomassie Blue. Most common these three tissue types, but there also differences. Polyps had a strikingly similar pattern, different that mucosa. There were negligible differences two-dimensional patients who...
Double-blind placebo-controlled food challenge (DBPCFC) with items applied in capsules was performed a prospective study of 17 selected patients and 34 age- sex-matched healthy controls the interdisciplinary clinical setting. Protein immunoblotting showed no differences antigenicity between foods corresponding fresh foods. All reacted to one or more substances during DBPCFC, doubtful reaction placebo 2 patients. Agreement diet history provocation seen 53 85 individual challenges, 36 being...
Enzymes activities in homogenates of the large intestine were measured biopsies from 11 tubular adenomas and six carcinomas corresponding normal mucosa each individual. A similar significant increase was found total glucose-6-phosphate dehydrogenase (G 6 PD), pyruvate kinase, lactate as compared with levels mucosa. The isoenzyme patterns showed also a marked change M-monomers. Most slight to moderate dysplasia. results indicate that measurement G PD, kinase for screening purposes has no...
This study was based on an endoscopic screening for detection of polyps in the rectum and sigmoid colon a randomized, normal population sample 400 individuals aged 50–59 years. Family disposition cancer indicators lifestyle (including dietary registration) were recorded. The 310 received domestic drinking water from one out four public supplies. participants categorized according to supply connected their house residence. Drinking analysed monthly during 2 years chloroform, total organic...
Total enzyme activity of glucose-6-phosphate dehydrogenase (G6PD) and lactate (LD) was measured in homogenates resected biopsy specimens endoscopic specimens. LD isoenzyme patterns were scanned by a laser technique after agarose gel electrophoresis. Examinations performed premalignant lesions such as ulcerative colitis adenomas the colon, with normal mucosa carcinomas control material. Additionally, two-dimensional electrophoretic protein compared for mucosa, adenomas, large intestine. The...
Objective: We report a case of an adolescent with diagnostic delay 16 months Crohn's disease, due to misdiagnosed growth hormone deficiency.The subject: The 14-year-old boy presented for short stature, after unsuccessful treatment during the last months.Results: clinical examination ruled out dwarfism, because patient had rather poor weight gain than stature failure.The history taking discovered new valuable points: recurrent oral ulcerations, anal fissures, anorexia.These elements were...
The Cancer Registry of Norway. Telemark Central Hospital, Skien, Ulleval Oslo, National University