A5019205404- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Inflammatory Bowel Disease
- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Treatments and Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Microscopic Colitis
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic factors in colorectal cancer
- Autoimmune and Inflammatory Disorders
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Cardiac tumors and thrombi
- Diversity and Career in Medicine
- Surgical Simulation and Training
- Esophageal Cancer Research and Treatment
- Neuroendocrine Tumor Research Advances
- Esophageal and GI Pathology
- Hospital Admissions and Outcomes
- Advanced Harmonic Analysis Research
- Vitamin D Research Studies
- Multiple and Secondary Primary Cancers
- Surgical site infection prevention
IRCCS Humanitas Research Hospital
2022-2025
KU Leuven
2023-2025
Humanitas University
2020-2024
University of Naples Federico II
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2023
Delays in screening programs and the reluctance of patients to seek medical attention because outbreak SARS-CoV-2 could be associated with risk more advanced colorectal cancers at diagnosis.To evaluate whether pandemic was oncologic stage change clinical presentation for cancer.This retrospective, multicenter cohort study included all 17 938 adult who underwent surgery cancer from March 1, 2020, December 31, 2021 (pandemic period), January 2018, February 29, 2020 (prepandemic 81...
Abstract Background We aimed to evaluate the impact of advanced medical therapies (biologicals and small molecules) on time colectomy oncological outcomes in UC. Methods This cohort study included UC patients who underwent between 2003 2022 at two referral centres Belgium Netherlands. Exposure was use therapies. Primary were colorectal cancer (CRC) rate, compared four periods: P1 (2003-2007), P2 (2008-2012), P3 (2013-2017), P4 (2018-2022). Secondary outcomes, including incidental cancers...
The incidence of colorectal cancer (CRC) is increasing in the population aged ≤ 49 (early-onset CRC-EOCRC). Recent studies highlighted biological and clinical differences between EOCRC late-onset CRC (LOCRC-age ≥ 50), while comparative results about long-term survival are still debated. This study aimed to investigate whether age onset may impact on oncologic outcomes a surgical sporadic patients. Patients operated for from January 2010 2022 were allocated LOCRC groups. primary endpoint was...
Abstract Background The association between volume, complications and pathological outcomes is still under debate regarding colorectal cancer surgery. aim of the study was to assess centre volume severe complications, mortality, less-than-radical oncologic surgery, indications for neoadjuvant therapy. Methods Retrospective analysis 16,883 cases from 80 centres (2018–2021). Outcomes: 30-day mortality; Clavien-Dindo grade >2 complications; removal ≥ 12 lymph nodes; non-radical...
Abstract Aim Recent evidence has questioned the usefulness of anastomotic drain (AD) after low anterior resection (LAR). However, implementation and adoption a no-drain policy are still poor. This study aims to assess clinical outcomes for rectal cancer surgery into real-life setting adherence surgeons such policy. Method A retrospective analysis was conducted on patients who underwent elective minimally invasive LAR between January 2015 December 2019 at two tertiary referral centers. In...
The incidence of rectal cancer (RC) is increasing in the population aged ≤ 49 (early-onset RC-EORC). EORC patients are more likely to present with locally advanced disease at diagnosis than late-onset RC (LORC; ≥ 50) patients. As a consequence, undergo neoadjuvant therapies. response treatment still unknown. This study aims explore effect age onset on pathological therapies sporadic (LARC) Based an institutional prospectively maintained database, LARC undergoing and radical surgery between...
Abstract Background Proctocolectomy with ileal pouch-anal anastomosis is the treatment of choice for patients ulcerative colitis medical refractory disease or dysplasia. The aim this research was to describe evolution surgery and surgical outcomes over a three-decade interval in high-volume referral centre. Methods All consecutive undergoing between 1990 2022 at University Hospitals Leuven were retrospectively included. Patients divided into three arms (interval A 1990–2000, B 2001–2010 C...
Abstract Background The expanding medical armamentarium in ulcerative colitis (UC) has contributed to increased control of inflammation. However, simultaneously, postponed colonic resection with an accumulative inflammatory burden might lead risk CRC. Recent studies have reported conflicting results regarding the incidence colorectal cancer (CRC) UC patients. Aim To analyse impact advanced therapies (defined as biologicals and small molecules) on time CRC Methods Consecutive patients ≥18...
Despite advancements in therapeutic options for Crohn's disease (CD), strictureplasty is a mainstay bowel-preserving technique small bowel CD. We sought to audit international practice across three high-volume centres since the widespread use of biologic medication.
The data that support the findings of this study are available from corresponding author upon reasonable request. Video S1: Please note: publisher is not responsible for content or functionality any supporting information supplied by authors. Any queries (other than missing content) should be directed to article.
Despite the advances in medical treatment of Crohn's disease (CD), most patients require one or more surgical bowel resections during their life for complicated disease.Surgery CD has gone through progressive technical refinement over time.Minimally invasive surgery and bowel-sparing techniques have been validated with regard to trauma reduction, role clearly defined current guidelines.Nevertheless, continuous technology advancement further expanded tools single-access robotic-assisted...
Abstract: Total mesorectal excision (TME) has become the gold standard technique for rectal cancer surgery with curative intent. Advantages in technology and surgical innovation lead to introduction of minimally invasive techniques including laparoscopic, robotic and, more recently, transanal TME (TaTME). The concept TaTME been proposed overcome technical challenges encountered transabdominal approaches (open, robotic) most difficult cases (obese, male patients mid-low a narrow, radiated...
Abstract New onset atrial fibrillation (AF) is observed in up to 37% of patients after esophagectomy for esophageal and esophago-gastric junction (EGJ) cancer. Little known about risk factors AF this cohort patients. Current literature describes an association between postoperative other complications, notably anastomotic leaks infective or pulmonary complications. The aim paper determine which relate increased new-onset esophagectomy. Methods We retrospectively analyzed a prospectively...
Flavio MILANA*, Simone FAMULARO, Antonio LUBERTO, Eloisa FRANCHI, Matteo CIMINO, Guido COSTA, Angela PALMISANO, Fabio PROCOPIO, DONADON, TORZILLI. Ann Hepatobiliary Pancreat Surg 2022;26:S227. https://doi.org/10.14701/ahbps.2022S1.LV-PP-9-4