Annalisa Comandatore
A5091428659- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Surgical Treatments
- Gallbladder and Bile Duct Disorders
- Extracellular vesicles in disease
- Anorectal Disease Treatments and Outcomes
- MicroRNA in disease regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Stoma care and complications
- Nutrition and Health in Aging
- Sarcoma Diagnosis and Treatment
- Surgical Simulation and Training
- Cardiac tumors and thrombi
- Cancer-related molecular mechanisms research
- Pediatric Hepatobiliary Diseases and Treatments
- Diverticular Disease and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Vascular Tumors and Angiosarcomas
- Minimally Invasive Surgical Techniques
- Caveolin-1 and cellular processes
- Hip and Femur Fractures
- Cancer Genomics and Diagnostics
University of Pisa
2021-2025
Amsterdam University Medical Centers
2021-2024
Amsterdam UMC Location Vrije Universiteit Amsterdam
2023-2024
Vrije Universiteit Amsterdam
2021-2024
Azienda Ospedaliera Universitaria Pisana
2022-2024
Ospedale Cisanello
2024
Cancer Center Amsterdam
2023
German Cancer Research Center
2023
PDAC is an extremely aggressive tumor with a poor prognosis and remarkable therapeutic resistance. The dense extracellular matrix (ECM) which characterizes progression considered fundamental determinant of chemoresistance, major contributions from mechanical factors. This study combined biomechanical pharmacological approaches to evaluate the role cell-adhesion molecule ITGA2, key regulator ECM, in resistance gemcitabine.The prognostic value ITGA2 was analysed publicly available databases...
Abstract Background Postoperative pancreatic fistula is the main driver of morbidity and mortality after pancreatoduodenectomy. In high-risk patients, rate postoperative approaches 50%, whereas it below 5% in patients with cancer who receive neoadjuvant chemoradiotherapy. The aim this study was to evaluate safety, feasibility, efficacy preoperative stereotactic body radiotherapy on neck transection margin undergoing pancreatoduodenectomy prevent fistula. Methods prospective multicentre...
Objective: The aim of this study is to identify learning curves for robotic gastro-enterostomy (RGE) during RPD and the predictive value objective structured assessment technical skills (OSATS) score DGE according Birkmeyer et al UPMC method. Summary Background Data: In some series, pancreatoduodenectomy (RPD) has been associated with increased risk delayed gastric emptying (DGE). It unclear whether attributable curve. Improved surgical performance experience not yet linked a decrease in...
Abstract Adrenalectomies are growing worldwide because of the frequent diagnosis incidentaloma and use minimally invasive surgery (MIS). The factors used to identify a malignant lesion best surgical technique uncertain. In this context, definition high-volume center expert surgeon is under debate. Italian Society Endoscopic Surgery New Technologies (SICE) developed nationwide survey investigate state-of-the-art adrenal in Italy. A web-based comprising 37 questions was distributed surgeons...
Abstract Background Intraductal papillary mucinous neoplasms (IPMNs) are precursors to pancreatic cancer, but not all IPMNs progress cancer. The objective of this study was identify the germline genetic variants associated with IPMN clinical progression by conducting first genome‐wide association (GWAS) and computing a polygenic hazard score (PHS) in 338 patients IPMN. Methods population divided into two subsets, Cox analysis adjusted for sex, age, cyst size at diagnosis, top 10 principal...
Pancreatic ductal adenocarcinoma (PDAC) poses significant challenges in terms of prognosis and treatment. Recent research has identified splicing deregulation as a new cancer hallmark. Herein, we investigated the largely uncharacterized alternative profile key factor SF3B1 PDAC pancreatic cells tissues potential discovery source plausible drug targets predictive biomarkers clinical outcome. The involved transcriptome-wide analysis, comparing profiles primary with normal cells. This revealed...
Accurate risk prediction models using routinely measured biomarkers-eg, carbohydrate antigen 19-9 (CA19-9) and bilirubin serum levels-for pancreatic cancer could facilitate early detection of prevent potentially unnecessary diagnostic tests for patients at low risk. An externally validated model CA19-9 levels in a larger cohort with or benign periampullary diseases is needed.To assess the discrimination, calibration, clinical utility readily available blood biomarkers (carbohydrate [CA19-9]...
Abstract Acute diverticulitis (AD) is associated with relevant morbidity/mortality and increasing worldwide, thus becoming a major issue for national health systems. AD may be challenging, as clinical relevance varies widely, ranging from asymptomatic picture to life-threatening conditions, continuously evolving diagnostic tools, classifications, management. A 33-item-questionnaire was administered residents surgeons analyze the actual practice verify real spread of recent recommendations,...
Background: In Bismuth type III and IV Hilar Cholangiocarcinoma (III–IV HC), surgical resection is the only chance for long-term survival. As procedure complex Robotic-Assisted Surgery (RAS) may be particularly suitable in this setting, aim of study to evaluate potential benefits RAS III–IV HC terms post-operative outcomes. Methods: We conducted a systematic review using PRISMA checklist article selection. searched PubMed database included studies with clinical data about treatment RAS....
Abstract Background Distinguishing benign from malignant pancreaticobiliary disease is challenging because of the absence reliable biomarkers. Circulating extracellular vesicles (EVs) have emerged as functional mediators between cells. Their cargos, including microRNAs (miRNAs), are increasingly acknowledged an important source potential This multicentric, prospective study aimed to establish a diagnostic plasma EV-derived miRNA signature discriminate pancreatic ductal adenocarcinoma (PDAC)...
Abstract Background Conventional Right Colectomy with D2 lymphadenectomy (RC-D2) currently represent the most common surgical treatment of right-sided colon cancer (RCC). However, whether it should be still considered a standard care, or replaced by routine more extended D3 remains unclear. In present study, we aim to critically review patterns relapse and survival outcomes obtained from our 11-year experience RC-D2. Methods Clinical data 489 patients who underwent RC-D2 for RCC at two...