Giulia Peduzzi
A5016817014- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Health, Environment, Cognitive Aging
- AI in cancer detection
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Helicobacter pylori-related gastroenterology studies
- Pancreatitis Pathology and Treatment
- Genetic Associations and Epidemiology
- Neuroendocrine Tumor Research Advances
- Artificial Intelligence in Healthcare
- RNA and protein synthesis mechanisms
- Cholesterol and Lipid Metabolism
- Biomarkers in Disease Mechanisms
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
- Lipid metabolism and disorders
- Telomeres, Telomerase, and Senescence
- Folate and B Vitamins Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gut microbiota and health
- Infant Nutrition and Health
- Fatty Acid Research and Health
University of Pisa
2019-2025
Abstract Pancreatic cancer is currently the seventh leading cause of death worldwide. Understanding whether modifiable factors increase or decrease risk this disease central to facilitating primary prevention. Several epidemiological studies have described benefits physical activity, and risks associated with sedentary behavior, in relation cancer. This study aimed assess evidence causal effects activity behavior on pancreatic risk. We conducted a two-sample Mendelian randomization using...
BackgroundThe current knowledge on pancreatic ductal adenocarcinoma (PDAC) risk factors is limited and no study has comprehensively tested the exposome in combination with genetic variability relation to disease susceptibility.AimThe aim of this was analyze its interaction known susceptibility loci, PDAC risk.MethodsA case-control nested UK Biobank cohort conducted 816 cases 302,645 controls. A total 347 exposure variables, a polygenic score (PRS) were analyzed through logistic regression....
There is a growing body of evidence on the effect local environment exposure cancer susceptibility. Nonetheless, several associations remain controversial. Moreover, our understanding possible interaction between and genetic variability still very limited.
Correlated regions of systemic interindividual variation (CoRSIV) represent a small proportion the human genome showing DNA methylation patterns that are same in all tissues, different among individuals, and partially regulated by genetic variants cis. In this study we aimed at investigating single-nucleotide polymorphisms (SNPs) within CoRSIVs their involvement with pancreatic ductal adenocarcinoma (PDAC) risk. We analyzed 29,099 CoRSIV-SNPs 133,615 CoRSIV-mQTLs 14,394 cases 247,022...
Abstract Background Intraductal papillary mucinous neoplasms (IPMNs) are precursors to pancreatic cancer, but not all IPMNs progress cancer. The objective of this study was identify the germline genetic variants associated with IPMN clinical progression by conducting first genome‐wide association (GWAS) and computing a polygenic hazard score (PHS) in 338 patients IPMN. Methods population divided into two subsets, Cox analysis adjusted for sex, age, cyst size at diagnosis, top 10 principal...
Abstract The incidence of pancreatic ductal adenocarcinoma (PDAC) is different among males and females. This disparity cannot be fully explained by the difference in terms exposure to known risk factors; therefore, lower women could attributed sex-specific hormones. A two-phase association study was conducted 12,387 female subjects (5436 PDAC cases 6951 controls) assess effect on developing single nucleotide polymorphisms (SNPs) 208 genes involved oestrogen pregnenolone biosynthesis...
There is overwhelming evidence that inflammation plays a key role in the pathogenesis of cancer and its progression. Inflammation regulated through complex network genes polymorphic variants these have been found to be associated risk various human cancers, alone or combination with environmental variables. Despite this, not much known on genetic variability regulate pancreatic ductal adenocarcinoma (PDAC). We performed two-phase association study considering 76 are players inflammatory...
The mitochondrial metabolism has been associated with pancreatic ductal adenocarcinoma (PDAC) risk. Recent evidence also suggests the involvement of genetic variability function in several traits involved PDAC etiology. However, a systematic investigation genome (mtSNP) and all nuclear genes its functioning (n-mtSNPs) never reported.We conducted two-phase association study mtSNPs n-mtSNPs to assess their effect on We analyzed 35,297 101 up 55,870 individuals (12,884 cases 42,986 controls)....
Abstract Recent studies indicate the existence of a complex microbiome in meconium newborns that plays key role regulating many host health-related conditions. However, high variability between has been observed so far. In present study, composition and predicted microbial metabolic pathways were analysed consecutive cohort 96 full-term newborns. The effect maternal epidemiological variables on diversity was using regression analysis PERMANOVA. Meconium mainly included Proteobacteria...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. The vast majority patients have unresectable or metastatic disease at diagnosis, with poor prognosis and very short survival. Considering this fact, it urgent to understand genetic basis susceptibility PDAC develop more individualized prevention strategies. For that purpose, we comprehensively investigated whether 55,583 variants within 234 autophagy-related genes could influence risk developing in three...