A5061877186- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Systemic Lupus Erythematosus Research
- SARS-CoV-2 detection and testing
- HIV Research and Treatment
- Systemic Sclerosis and Related Diseases
- Rheumatoid Arthritis Research and Therapies
- Fibroblast Growth Factor Research
- Viral-associated cancers and disorders
- Bone health and osteoporosis research
- Injury Epidemiology and Prevention
- Lymphoma Diagnosis and Treatment
- Sports injuries and prevention
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Polyomavirus and related diseases
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Shoulder Injury and Treatment
Florida International University
2024-2025
Emory University
2025
Universitat de Miguel Hernández d'Elx
2003-2024
Hospital General Universitario de Elche
2003-2024
Instituto de Salud Carlos III
2021-2024
Centro de Investigación Biomédica en Red
2022-2024
Hospital Clínico San Carlos
2023
Hospital Vega Baja
2023
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2023
Hospital Universitario Infanta Sofía
2020-2022
From 1958 to 1970, >100,000 people in northern Chile were exposed a well-documented, distinct period of high drinking water arsenic concentrations. We previously reported ecological evidence suggesting that early-life exposure this population resulted increased mortality adults from several outcomes, including lung and bladder cancer.
BackgroundThe virological and immunological effects of the immunomodulatory drugs used for COVID-19 remain unknown. We evaluated impact interleukin (IL)-6 blockade with tocilizumab on SARS-CoV-2 viral kinetics antibody response in patients COVID-19.MethodsProspective cohort study admitted COVID-19. Serial nasopharyngeal plasma samples were measured RNA S-IgG/N-IgG titers, respectively.Findings138 confirmed infection included; 76 (55%) underwent IL-6 blockade. Median initial SOFA (p = 0•016)...
The interdependencies of viral replication and the host immune response in patients with coronavirus disease 2019 (COVID-19) remain to be defined. We investigated determinants antibody response, predictors nonseroconversion, role antibodies on dynamics.This was a prospective study hospitalized COVID-19 that microbiologically confirmed by real-time polymerase chain reaction (RT-PCR). Serial nasopharyngeal oropharyngeal swabs plasma samples were obtained for measuring severe acute respiratory...
Background The pathophysiology of long-COVID remains unknown, and information is particularly limited for symptoms very long duration. We aimed to assess the serological, T-cell immune responses ANA titers patients with long-COVID-19 syndrome 1-year Methods Prospective, longitudinal study hospitalized COVID-19 followed-up 12 months. Sequential blood samples symptom questionnaires (CSQ) were obtained, humoral cellular responses, antinuclear antibodies (ANA) inflammation biomarkers analyzed....
Performance of point-of-care tests in different clinical scenarios and on samples remains undetermined. We comprehensively evaluated the performance nasopharyngeal Panbio COVID-19 Ag Rapid Test Device.
BackgroundWhether interleukin-6 (IL-6) blockade in patients with COVID-19 will affect the protective immunity against SARS-CoV-2 has become an important concern for anti-IL-6 therapy. We aimed to investigate effects of IL-6 on long-term SARS-CoV-2.MethodsProspective, longitudinal cohort study conducted hospitalized severe or critical laboratory confirmed infection. assessed humoral (anti-S1 domain spike [S], anti-nucleocapsid [N], anti-trimeric [TrimericS] IgG, and neutralizing antibodies...
Abstract Objectives To assess the effectiveness and tolerability of dolutegravir (DTG)/lamivudine (3TC) among treatment-naive virologically suppressed treatment-experienced individuals in multicentre cohort Spanish HIV/AIDS Research Network (CoRIS) during years 2018–2021. Methods We used multivariable regression models to compare viral suppression (VS) [HIV RNA load (VL) <50 copies/mL] change CD4 cell counts at 24 48 (±12) weeks after initiation with dolutegravir/lamivudine or other...
This prospective study aimed to determine the prevalence of long COVID in patients hospitalized for SARS-CoV-2 infection from March 2020 July 2022 and assess impact different viral lineages. A total 2,524 were followed up 12 months, with persistent symptoms reported 35.2% at one month, decreasing thereafter. Omicron variant initially showed higher symptom intensity, but this trend diminished over time. Certain lineages, notably Delta lineages AY.126 AY.43, sublineages BA.1.17, BA.2.56,...
Abstract Excessive interleukin-6 signaling is a key factor contributing to the cytokine release syndrome implicated in clinical manifestations of COVID-19. Preliminary results suggest that tocilizumab, humanized monoclonal anti-interleukin-6 receptor antibody, may be beneficial severely ill patients, but no data are available on earlier stages disease. An anticipated blockade might hypothetically prevent catastrophic consequences overt storm. We evaluated early-given tocilizumab patients...
We evaluated a standardized interferon-γ (IFN-γ) release assay (IGRA) for detection of T-cell immune response after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or vaccination.This prospective study included patients with disease 2019 (COVID-19) different severity illness and follow-up (FU), vaccinated subjects, healthy unvaccinated persons. SARS-CoV-2 was measured using specific quantitative IGRA in whole blood (Euroimmun, Germany) TrimericS-IgG neutralizing...
BackgroundWhile a low CD4/CD8 ratio during HIV treatment correlates with immunosenescence, its value in identifying patients at an increased risk for clinical events remains unclear.MethodsWe analyzed data from the CoRIS cohort to determine whether CD4 count, CD8 and year two of antiretroviral therapy (ART) could predict serious non-AIDS (SNAEs) next five years. These included major adverse cardiovascular events, non-AIDS-defining malignancies, non-accidental deaths. We used pooled logistic...
Chlamydia trachomatis-lymphogranuloma venereum (LGV) is a sexually transmitted infection (STI) and an uncommon cause of proctitis rectal mass. When the rectum affected, patients may experience symptoms such as bleeding, pain, tenesmus, which can resemble or proctocolitis be mistaken for malignancy. We present case 40-year-old male patient with well-controlled HIV, who initially exhibited imaging findings concerning neoplasia. Following colonoscopy biopsy swab polymerase chain reaction (PCR),...
Data on the performance of saliva specimens for diagnosing coronavirus disease 2019 (COVID-19) in ambulatory patients are scarce and inconsistent. We assessed saliva-based detecting severe acute respiratory syndrome 2 (SARS-CoV-2) by reverse transcriptase PCR (RT-PCR) community setting compared three different collection methods. This prospective study was conducted primary care centers. RT-PCR performed paired nasopharyngeal swabs (NPS) samples collected from outpatients with a broad...
To assess the benefits of remdesivir in hospitalized COVID-19 patients receiving combined immunomodulatory therapy (CIT) with dexamethasone and tocilizumab.This was a cohort study microbiologically confirmed patients. The primary outcome all-cause 28 day mortality. Secondary outcomes were need for invasive mechanical ventilation (IMV) IMV/death. Subgroup analyses according to SARS-CoV-2 cycle threshold (Ct) values inflammation biomarkers performed. Multivariable marginal structural Cox...
The aim of this study was to determine the association playing style and efficacy variables with football success in a professional league. Match statistics were obtained from 23 teams competing 2017-2018 2018-2019 seasons Spanish national league(LaLiga). Offensive defensive calculated. Pearson's correlation coefficient tests principal component analysis (PCA) applied establish influence these on number points at end season ranking position. In isolation, completion showed highest A...