A5069821209- Optical Coherence Tomography Applications
- Photoacoustic and Ultrasonic Imaging
- Advanced Fluorescence Microscopy Techniques
- Optical Imaging and Spectroscopy Techniques
- Non-Invasive Vital Sign Monitoring
- Spectroscopy Techniques in Biomedical and Chemical Research
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Physics of Superconductivity and Magnetism
- Ocular and Laser Science Research
- Retinal Development and Disorders
- Hemodynamic Monitoring and Therapy
- Retinal and Macular Surgery
- Corneal surgery and disorders
- Iron-based superconductors research
- Rare-earth and actinide compounds
- Cold Atom Physics and Bose-Einstein Condensates
- Mobile and Web Applications
- Intraocular Surgery and Lenses
- Random lasers and scattering media
- Photoreceptor and optogenetics research
- Quantum and electron transport phenomena
- Quantum, superfluid, helium dynamics
- Spectroscopy and Chemometric Analyses
Institute of Physical Chemistry
2017-2024
International Institute for Molecular Oncology
2021-2024
Polish Academy of Sciences
2017-2024
Duke University
2021
Tsinghua University
2021
University of California, Davis
2016-2018
Institute of Physics
2013-2016
Nicolaus Copernicus University
2013-2016
Soka University of America
2008
Fourier-domain full-field optical coherence tomography (FD-FF-OCT) is currently the fastest volumetric imaging technique that able to generate a single 3-D volume of retina in less than 9 ms, corresponding voxel rate 7.8 GHz. FD-FF-OCT based on fast camera, rapidly tunable laser source, and signal detection. However, crosstalk appearing due multiply scattered light corrupts images with speckle pattern, therefore, lowers image quality. Here, for first time, we report system can acquire...
Corneal evaluation in ophthalmology necessitates cellular-resolution and fast imaging techniques that allow for accurate diagnoses. Currently, the fastest volumetric technique is Fourier-domain full-field optical coherence tomography (FD-FF-OCT), which uses a camera rapidly tunable laser source. Here, we demonstrate high-resolution, high-speed, non-contact corneal vivo with FD-FF-OCT can acquire single 3D volume voxel rate of 7.8 GHz. The spatial source was suppressed to prevent it from...
Diffuse correlation spectroscopy (DCS) is a well-established method that measures rapid changes in scattered coherent light to identify blood flow and functional dynamics within tissue. While its sensitivity minute scatterer displacements leads number of unique advantages, conventional DCS systems become photon-limited when attempting probe deep into the tissue, which long measurement windows (∽1 sec). Here, we present high-sensitivity system with 1024 parallel detection channels integrated...
Abstract Monitoring of human tissue hemodynamics is invaluable in clinics as the proper blood flow regulates cellular-level metabolism. Time-domain diffuse correlation spectroscopy (TD-DCS) enables noninvasive measurements by analyzing temporal intensity fluctuations scattered light. With time-of-flight (TOF) resolution, TD-DCS should decompose at different sample depths. For example, head, it allows us to distinguish flows scalp, skull, or cortex. However, tissues are typically...
Despite the rapid development of optical imaging methods, high-resolution in vivo with penetration into deeper tissue layers is still a major challenge. Optical coherence tomography (OCT) has been used successfully for non-invasive human retinal volumetric vivo, advancing detection, diagnosis, and monitoring various diseases. However, there are important limitations OCT imaging, especially coherent noise limited axial range over which high resolution images can be acquired. The prevents...
For many years electroretinography (ERG) has been used for obtaining information about the retinal physiological function. More recently, a new technique called optoretinography (ORG) developed. In one form of this technique, response photoreceptors to visible light, resulting in nanometric photoreceptor optical path length change, is measured by phase-sensitive coherence tomography (OCT). To date, limited number studies with phase-based ORG flickering light stimulation. work, we use...
Fourier-domain full-field optical coherence tomography (FD-FF-OCT) has recently emerged as a fast alternative to point-scanning confocal OCT in eye imaging. However, when imaging the cornea with FD-FF-OCT, spatially coherent laser can focus down on retina spot that exceeds maximum permissible exposure level. Here we demonstrate long multimode fiber small core be used reduce spatial of and, thus, enable ultrafast vivo volumetric human without causing risk retina.
Fourier-domain full-field optical coherence tomography (FD-FF-OCT) is an emerging tool for high-speed eye imaging. However, cross-talk formation in images limits the imaging depth. To this end, we have recently shown that reducing spatial with a fast deformable membrane can suppress noise but over limited axial range and substantial data processing. Here, demonstrate multimode fiber carefully chosen parameters enables cross-talk-free long without significant artifacts. We also show it be...
We introduce and implement interferometric near-infrared spectroscopy (iNIRS), which simultaneously extracts optical dynamical properties of turbid media through analysis a spectral interference fringe pattern.The pattern is measured using Mach-Zehnder interferometer with frequency-swept narrow linewidth laser.Fourier the detected signal used to determine timeof-flight (TOF)-resolved intensity, then analyzed over time yield TOF-resolved intensity autocorrelations.This approach enables...
Full-field swept-source optical coherence tomography (FF-SS-OCT) provides high-resolution depth-resolved images of the sample by parallel Fourier-domain interferometric detection. Although FF-SS-OCT implements high-speed volumetric imaging, it suffers from cross-talk-generated noise spatially coherent lasers. This reduces transversal image resolution, which in turn, limits wide adaptation for practical and clinical applications. Here, we introduce novel spatiotemporal (STOC) manipulation. In...
Spatiotemporal optical coherence (STOC) imaging is a new technique for suppressing coherent cross talk noise in Fourier-domain full-field tomography (FD-FF-OCT). In STOC imaging, the time-varying inhomogeneous phase masks modulate incident light to alter interferometric signal. Resulting interference images are then processed as standard FD-FF-OCT and averaged incoherently or coherently produce cross-talk-free volumetric (OCT) of sample. Here, we show that averaging suitable when modulation...
Sensing and imaging methods based on the dynamic scattering of coherent light (including laser speckle, Doppler, diffuse correlation spectroscopy, scattering, diffusing wave spectroscopy) quantify scatterer motion using intensity fluctuations. The underlying optical field autocorrelation, rather than being measured directly, is typically inferred from autocorrelation through Siegert relationship, assuming that scattered obeys Gaussian statistics. Here, we demonstrate interferometric...
Microcirculation and neurovascular coupling are important parameters to study in neurological neuro-ophthalmic conditions. As the retina shares many similarities with cerebral cortex is optically accessible, a special focus directed assessing chorioretinal structure, microvasculature, hemodynamics of mice, vital animal model for vision neuroscience research.
Interferometric near-infrared spectroscopy (iNIRS) is a new technique that measures time-of-flight- (TOF-) resolved autocorrelations in turbid media, enabling simultaneous estimation of optical and dynamical properties. Here, we demonstrate reflectance-mode iNIRS for noninvasive monitoring mouse brain vivo. A method more precise quantification with less static interference from superficial layers, based on separating dynamic components the field autocorrelation, presented. Absolute values...
Interferometric near-infrared spectroscopy (iNIRS) is an optical method that noninvasively measures the and dynamic properties of human brain in vivo. However, original iNIRS technique uses single-mode fibers for light collection, which reduces detected throughput. The reduced throughput compensated by relatively long measurement or integration times (∼1 sec), preclude monitoring rapid blood flow changes could be linked to neural activation. Here, we propose parallel interferometric (πNIRS)...
Interferometric near-infrared spectroscopy (iNIRS) is a time-of-flight- (TOF-) resolved sensing modality for determining optical and dynamical properties of turbid medium. iNIRS achieves this by measuring the interference spectrum light traversing medium with rapidly tunable, or frequency-swept, source. Thus, system performance critically depends on source detection apparatus. Using current-tuned 855 nm distributed feedback laser as source, we experimentally characterize parameters,...
Spatio-Temporal Optical Coherence Tomography (STOC-T) is a novel imaging technique using light with controlled spatial and temporal coherence. Retinal images obtained the STOC-T system maintain high resolution in all three dimensions, on sample of about 700 μm, without need for mechanical scanning. In present work, we use known data processing algorithms optical coherence tomography angiography (OCTA) modify them to improve rendering vasculature human retina at different depths by...
Spatiotemporal optical coherence tomography (STOC-T) is the novel modality for high-speed, crosstalk- and aberration-free volumetric imaging of biological tissue in vivo. STOC-T extends Fourier-Domain holographic Optical Coherence Tomography by spatial phase modulation that enables reduction tunable laser. By reducing laser, we suppress coherent noise, and, consequently, improve depth. Furthermore, remove geometrical aberrations computationally postprocessing. We recently demonstrated...
Time-domain diffuse correlation spectroscopy (td-DCS) enables the depth discrimination in tissue’s blood flow recovery, considering fraction of photons detected with higher time flight (TOF) and longer pathlength through tissue. However, recovery result depends on factors such as instrument response function (IRF), analyzed TOF gate start time, width source-detector separation (SDS). In this research we evaluate performance td-DCS technique at three SDSs 1.5, 2 2.5 cm to recover cerebral...
Time-domain diffuse correlation spectroscopy (TD-DCS) is an emerging optical technique that enables noninvasive measurement of microvascular blood flow with photon path-length resolution. In TD-DCS, a picosecond pulsed laser long coherence length, adequate illumination power, and narrow instrument response function (IRF) required, satisfying all these features challenging. To this purpose, in study we characterized the performance three different sources for TD-DCS. First, were evaluated...