A5027628466- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Chemical synthesis and alkaloids
- Biochemical Analysis and Sensing Techniques
- Chemical Synthesis and Analysis
- Neurotransmitter Receptor Influence on Behavior
- Chemical Reactions and Isotopes
- Analytical Methods in Pharmaceuticals
- Cancer Treatment and Pharmacology
- Mass Spectrometry Techniques and Applications
- Phosphodiesterase function and regulation
- Autophagy in Disease and Therapy
- Psychedelics and Drug Studies
- Food Allergy and Anaphylaxis Research
- Neuroscience and Neural Engineering
- Ion Channels and Receptors
- Mast cells and histamine
- Pharmacological Receptor Mechanisms and Effects
- Pain Management and Opioid Use
- Cell Image Analysis Techniques
- Gene Regulatory Network Analysis
- Ferrocene Chemistry and Applications
- Synthesis of Organic Compounds
University of North Carolina at Chapel Hill
2015-2024
International Neuromodulation Society
2019
National Institute of Mental Health
2018
Loyola University Chicago
2012-2016
National Institute of Environmental Health Sciences
2012
Drugs frequently require interactions with multiple targets—via a process known as polypharmacology—to achieve their therapeutic actions. Currently, drugs targeting several serotonin receptors, including the 5-HT2C receptor, are useful for treating obesity, drug abuse, and schizophrenia. The competing challenges of developing selective receptor ligands or creating defined polypharmacological profile, especially aimed at G protein-coupled receptors (GPCRs), remain extremely difficult. Here,...
Traditionally the hERG1 potassium channel has been known to have a fundamental role in membrane excitability of several mammalian cells including cardiac myocytes. recently found be expressed non-excitable cancer different histogenesis, but this biology is unknown. Results form recent studies on effect inhibition some breast are controversial as it can lead apoptosis or protect against cell death. Nevertheless, these data suggest that could an important biology. Here we report effects...
// Mathew Perez-Neut 1 , Lauren Haar Vidhya Rao Sreevidya Santha Katherine Lansu Basabi Rana Walter K. Jones Saverio Gentile Department of Molecular Pharmacology & Therapeutics, Loyola University, Chicago, IL-60153, USA Correspondence to: Gentile, e-mail: sagentile@luc.edu Keywords: potassium channels, autophagy, hERG, senescence, melanoma Received: January 12, 2016 Accepted: February 15, Published: March 01, 2016 ABSTRACT Ion channels play a major factor in...
In the U.S., more than 80% of African-American smokers use mentholated cigarettes, compared to less 30% Caucasian smokers. The reasons for these differences are not well understood. To determine if genetic variation contributes cigarette smoking, we performed an exome-wide association analysis in a multiethnic population-based sample from Dallas, TX (N = 561). Findings were replicated independent cohort African Americans Washington, DC 741). We identified haplotype MRGPRX4 (composed...
As the meningeally derived, fibroblast-rich, mass-produced by intrathecal morphine infusion is not produced all opiates, but reduced mast cell stabilizers, authors hypothesized a role for meningeal cell/fibroblast activation. Using guinea pig, asked: (1) Are masses blocked opiate antagonism?; (2) Do opioid agonists producing degranulation or fibroblast activation produce masses?; and (3) covary with Mas-related G protein-coupled receptor signaling thought to mediate degranulation?In adult...
Mutations that inhibit Kv11.1 ion channel activity contribute to abnormalities of cardiac repolarization can lead long QT2 (LQT2) arrhythmias and sudden death. However, for most these mutations, nothing is known about the molecular mechanism linking malfunction We have previously demonstrated disease-related mutations create consensus sites kinases on channels dramatically change activity. Here, we show a LQT2-associated mutation by perturbing site Ser/Thr protein kinase C α (PKCα). first...
Function of the hERG1 potassium channel has been well characterized in heart where it plays an important role contraction. However, is expressed cancers different hystogenesis. Although inhibiting activity can lead to apoptosis, this approach not likely be successful cancer therapy because association between blocking agents and cardiac ventricular fibrillation. Nevertheless, agonist NS1643 found protect against arrhythmia but nothing known about effects drug cells. The most breast treatment...
Female gender is an independent risk factor for several channelopathies. Malfunction of the potassium channel encoded by human ether a‐go‐go related gene 1 (hERG1) which associates with Long QT type 2 (LQT2) syndromes more prominent in women. In addition, drug‐induced LQT2 appears to fluctuate during different phases menstrual cycle. This raised question that steroid sex hormone estrogen (E ) could play a major role regulating hERG channel. E effects on cell targets have been explained...