A5061051202- Magnetic confinement fusion research
- Receptor Mechanisms and Signaling
- Superconducting Materials and Applications
- Biochemical and Structural Characterization
- Particle accelerators and beam dynamics
- HVDC Systems and Fault Protection
- Enzyme Production and Characterization
- Neuropeptides and Animal Physiology
- Electromagnetic Launch and Propulsion Technology
- Neuroscience and Neuropharmacology Research
- High-Voltage Power Transmission Systems
- Lightning and Electromagnetic Phenomena
- Cannabis and Cannabinoid Research
- Peptidase Inhibition and Analysis
- Microbial Metabolites in Food Biotechnology
- Cervical Cancer and HPV Research
- Pharmacological Effects and Assays
- Smart Grid and Power Systems
- Plant Diversity and Evolution
- Plant and Fungal Species Descriptions
- Genomics and Phylogenetic Studies
- Power Systems Fault Detection
- Pharmacological Receptor Mechanisms and Effects
- Advanced Algorithms and Applications
- Electrostatic Discharge in Electronics
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
China Southern Power Grid (China)
2020-2024
Peking Union Medical College Hospital
2024
ShanghaiTech University
2016-2023
Beijing Sport University
2023
Tsinghua University
2021
Institute of Biophysics
2014-2019
Chinese Academy of Sciences
2014-2019
University of Chinese Academy of Sciences
2019
Fujian Normal University
2018
The cannabinoid receptor CB2 is predominately expressed in the immune system, and selective modulation of without psychoactivity CB1 has therapeutic potential inflammatory, fibrotic, neurodegenerative diseases. Here, we report crystal structure human complex with a rationally designed antagonist, AM10257, at 2.8 Å resolution. CB2-AM10257 reveals distinctly different binding pose compared CB1. However, extracellular portion antagonist-bound shares high degree conformational similarity...
Drugs frequently require interactions with multiple targets—via a process known as polypharmacology—to achieve their therapeutic actions. Currently, drugs targeting several serotonin receptors, including the 5-HT2C receptor, are useful for treating obesity, drug abuse, and schizophrenia. The competing challenges of developing selective receptor ligands or creating defined polypharmacological profile, especially aimed at G protein-coupled receptors (GPCRs), remain extremely difficult. Here,...
Maternal stress is a potential factor affecting fetal growth, but it unknown whether directly affects growth restriction. This study aims to investigate the association between pre-pregnancy maternal with small for gestational age (SGA). used population-based retrospective cohort analysis examine and SGA in offspring. Data were extracted from National Preconception Health Care Project (NPHCP), conducted 2010 2012, which encompassed preconception health-related information 572,989 individuals...
Abstract The hydroxycarboxylic acid receptor 2 (HCA2) agonist niacin has been used as treatment for dyslipidemia several decades albeit with skin flushing a common side-effect in treated individuals. Extensive efforts have made to identify HCA2 targeting lipid lowering agents fewer adverse effects, despite little being known about the molecular basis of mediated signalling. Here, we report cryo-electron microscopy structure HCA2-G i signalling complex potent MK-6892, along crystal structures...
Adrenergic receptors are highly homologous while at the same time display a wide diversity of ligand and G-protein binding, understanding this is key for designing selective or biased drugs them. Here, we determine two crystal structures α2A adrenergic receptor (α2AAR) in complex with partial agonist an antagonist. Key non-conserved residues from ligand-binding pocket (Phe7.39 Tyr6.55) to coupling region (Ile34.51 Lys34.56) discovered play role interplay between agonism signaling α2AAR,...
Impurity toroidal rotation has been observed in the centre of ohmic plasmas Alcator C-Mod tokamak from Doppler shifts argon and molybdenum X-ray lines. The is highest (~6 × 106 cm/s) early portion discharges, when loop voltage electron density lowest, then typically settles to values ⩽ 2 cm/s during steady state period. impurity same direction as drift, opposite plasma current, reverses current reversed. Molybdenum ions rotate with velocity. These observations are qualitative agreement...
Abstract The risk associated with single and multiple human papillomavirus (HPV) infections in cervical intraepithelial neoplasia (CIN) remains uncertain. This study aims to explore the distribution diagnostic significance of number high‐risk HPV (hr‐HPV) detecting CIN, addressing a crucial gap our understanding. comprehensive multicenter, retrospective meticulously analyzed hr‐HPV, CIN2+, relationship impact on performance colposcopy using demographic information, clinical histories, tissue...
Highlights•Crystal structure of human α2CAR in complex with RS79948 is solved•A specific loosened helix at the top TM4 involved receptor activation•Extracellular regions play a role determining α2 adrenergic subtype selectivitySummaryAdrenergic G-protein-coupled receptors (GPCRs) mediate different cellular signaling pathways presence endogenous catecholamines and important roles both physiological pathological conditions. Extensive studies have been carried out to investigate function β...
Hydrocotyle, belonging to the Hydrocotyloideae of Araliaceae, consists 95 perennial and 35 annual species. Due lack stable diagnostic morphological characteristics high-resolution molecular markers, phylogenetic relationships Hydrocotyle need be further investigated. In this study, we newly sequenced assembled 13 whole plastid genomes performed comparative genomic analyses with four previously published plastomes phylogenomic within Araliaceae. The exhibited typical quadripartite structures...
Objective The value of the transformation zone (TZ) is often overlooked in clinical settings. This study aims to assess TZ distribution, associated factors, and its impact on colposcopic diagnosis. Methods χ 2 tests were used analyze demographics, history, tissue samples examine differences distribution. Factors affecting explored using logistic regression, diagnostic indicators calculated. Results A total 5,302 individual datasets finally included. TZ1, TZ2, TZ3 accounted for 31.6%, 38.5%,...
The relation between vertical field <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${B}_{z}$ </tex-math></inline-formula> and normalized plasma density to the current notation="LaTeX">$\overline {n_{e}} / {I}_{p}$ on Experimental Advanced Superconducting Tokamak (EAST) is derived quasi-linearity them found in flat-top phase of elongated current. poloidal pressure ratio notation="LaTeX">${\beta }_{p}$...
The China fusion engineering test reactor (CFETR) is an ITER-like tokamak system for energy development. It could output 50-200 MW power in phase I demonstrating generation with complete structure of plant, and 1 GW can be expected II. Its HV substation receives from the 500 kV transmission grid powering its pulsed electric network (PPEN) steady-state (SSEN). This paper describes concept design system, emphasis on turbine generator implemented flexible doubly fed induction (DFIG). DFIG has...
An increase in the magnetic strength of vertical field will, general, compress and heat plasmas, which thus allows high temperature, density, beta to be reached. In this paper, according scaling laws for compression, range both major-radius compression minor-radius is figured out. Then, comparison between carried It demonstrates that can obtain higher <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${\beta...