A5039783759- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiovascular and exercise physiology
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Health and Risk Factors
- Physical Activity and Health
- Cardiovascular Function and Risk Factors
- Nutrition and Health in Aging
- Cardiac Health and Mental Health
- ECG Monitoring and Analysis
- Heart Failure Treatment and Management
- Heart Rate Variability and Autonomic Control
- Cardiovascular Effects of Exercise
- Cardiac Arrest and Resuscitation
- Cardiovascular Issues in Pregnancy
- Viral Infections and Immunology Research
- Rheumatoid Arthritis Research and Therapies
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Acute Myocardial Infarction Research
- Infective Endocarditis Diagnosis and Management
- Drug-Induced Ocular Toxicity
Washington DC VA Medical Center
2014-2023
Rutgers, The State University of New Jersey
2023
Georgetown University
2002-2022
George Washington University
2009-2022
Veterans Health Administration
2005-2021
Burke Foundation
2019
Heart Rhythm Society
2012
Society of Thoracic Surgeons
2012
American Association for Thoracic Surgery
2012
Association of Chartered Certified Accountants
2012
Exercise capacity is inversely related to mortality risk in healthy individuals and those with cardiovascular diseases. This evidence based largely on white populations, little information available for blacks.
Epidemiological findings, based largely on middle-aged populations, support an inverse and independent association between exercise capacity mortality risk. The information available in older individuals is limited.Between 1986 2008, we assessed the all-cause 5314 male veterans aged 65 to 92 years (mean+/-SD, 71.4+/-5.0 years) who completed test at Veterans Affairs Medical Centers Washington, DC, Palo Alto, Calif. We established fitness categories peak metabolic equivalents (METs) achieved....
Background— Malignant cardiac arrhythmias can be triggered by exercise and mental stress in vulnerable patients. Exercise-induced T-wave alternans (TWA) is an established marker of electrical instability. However, the effects acute on TWA have not been investigated as a vulnerability humans. Methods Results— responses to (anger recall arithmetic) bicycle ergometry were evaluated patients with implantable cardioverter defibrillators (ICDs) documented coronary artery disease (n=23, age...
BACKGROUND Biphasic waveforms reduce defibrillation threshold (DFT) in a wide variety of models. Although there are several human studies long-duration, high-tilt biphasic waveform defibrillation, the specific shape required to achieve optimal DFT reduction is unknown. METHODS AND RESULTS This study tested effect single capacitor tilt modification on using paired design 18 patients undergoing nonthoracotomy defibrillator implantation. Baseline was obtained 65% tilt, simultaneous pulse,...
Background Although programmed electrical stimulation is widely used for provoking sustained ventricular tachycardia (VT), the mechanism by which repetitive extrastimulation evokes VT still little understood. Specifically, it not clear why several closely coupled extrastimuli are frequently required to induce VT. regularly paced human myocardium exhibits a near constant relation between myocardial repolarization and refractoriness, effect of on excitability in heart its relevance arrhythmia...
Hydroxychloroquine (HCQ) may prolong the QT interval, a risk factor for torsade de pointes, potentially fatal ventricular arrhythmia. This study was undertaken to examine cardiovascular safety of HCQ in patients with rheumatoid arthritis (RA).We conducted an active comparator propensity score-matched cohort 8,852 US veterans newly diagnosed as having RA between October 1, 2001 and December 31, 2017. Patients were started on (n = 4,426) or another nonbiologic disease-modifying antirheumatic...
Background: Heart failure is associated with ventricular tachyarrhythmias (VT/VF). Fluid accumulation during worsened heart may trigger VT/VF. Increased intrathoracic impedance has been correlated fluid failure. Implanted defibrillators capable of daily measures allow correlation occurrence We hypothesized that VT/VF episodes are preceded by decreases in impedance. The goal was to identify the relationship measured implanted cardioverter Method: defibrillator follow-up data were obtained...
Defibrillator implanters have adopted different approaches to managing failures of multicomponent implanted cardioverter defibrillator (ICD) leads. Although recent publications identified single-component as common mechanisms failure, there are no published data regarding how best manage these failures.An internet-based survey was conducted identify current management strategies. Questions were asked isolated failure a high-voltage coil or pace/sense electrode, in order the frequency various...