A5038593945- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Vector-Borne Animal Diseases
- Animal Virus Infections Studies
- Infection Control and Ventilation
- Mosquito-borne diseases and control
- Fire effects on ecosystems
- Energy and Environment Impacts
- COVID-19 impact on air quality
- COVID-19 and healthcare impacts
- SARS-CoV-2 detection and testing
- Bacillus and Francisella bacterial research
- Immunotherapy and Immune Responses
- Transgenic Plants and Applications
- Rabies epidemiology and control
- Streptococcal Infections and Treatments
- Anesthesia and Neurotoxicity Research
- Virology and Viral Diseases
- Vector-borne infectious diseases
- Thermal Regulation in Medicine
- Microbial infections and disease research
- Herpesvirus Infections and Treatments
Colorado State University
2019-2024
Kansas State University
2015-2021
Animal and Plant Health Inspection Service
2021
Significance SARS-CoV-2 is an emerging pathogen that has already had catastrophic consequences on the health and well-being of people worldwide. As a zoonotic virus, implications for animal populations are largely unknown. This manuscript describes pilot study in which domestic cats dogs were assessed their susceptibility to infection. While neither species developed clinical disease this study, shed infectious virus up 5 d infected naive via direct contact, while do not appear virus. Cats...
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has recently been identified as the causative agent for Disease 2019 (COVID-19). The ability of this to be transmitted by blood transfusion not documented, although viral RNA detected in serum. Exposure treatment with riboflavin and ultraviolet light (R + UV) reduces blood-borne pathogens while maintaining product quality. Here, we report on efficacy R UV reducing SARS-CoV-2 infectivity when tested human plasma whole products.
Severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is a member family. Coronavirus infections in humans are typically associated with illnesses; however, viral RNA has been isolated serum from infected patients. Coronaviruses have identified as potential low-risk threat to blood safety. The Mirasol Pathogen Reduction Technology (PRT) System utilizes riboflavin and ultraviolet (UV) light render blood-borne...
RNA vaccines have demonstrated efficacy against SARS-CoV-2 in humans, and the technology is being leveraged for rapid emergency response. In this report, we assessed immunogenicity and, first time, toxicity, biodistribution, protective preclinical models of a two-dose self-amplifying messenger (SAM) vaccine, encoding prefusion-stabilized spike antigen Wuhan-Hu-1 strain delivered by lipid nanoparticles (LNPs). mice, one immunization with SAM vaccine elicited robust spike-specific antibody...
In 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) emerged. To date, more than 2300 cases have been reported, with an approximate case fatality rate of 35%. Epidemiological investigations identified dromedary camels as the source MERS-CoV zoonotic transmission and evidence circulation has observed throughout original range distribution. Other new-world camelids, alpacas llamas, are also susceptible to infection. Currently, it is unknown whether Bactrian The distribution...
The recent emergence of the mosquito-borne Zika virus (ZIKV) in Americas has become a global public health concern. We describe series experimental infections designed to investigate whether animals within certain taxonomic groups North America have potential serve as ZIKV amplifying or maintenance hosts. Species investigated included armadillos, cottontail rabbits, goats, mink, chickens, pigeons, ground hogs, deer mice, cattle, raccoons, ducks, Syrian Golden hamsters, garter snakes, leopard...
Abstract Arthropod-borne viruses represent a crucial public health threat. Current arboviral serology assays are either labor intensive or incapable of distinguishing closely related viruses, and many zoonotic arboviruses that may transition to humans lack any serologic assays. In this study, we present programmable phage display platform, ArboScan, evaluates antibody binding overlapping peptides the proteomes 691 human arboviruses. We confirm ArboScan provides detailed information from...
ABSTRACT BACKGROUND Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has recently been identified as the causative agent for Disease 2019 (COVID-19). The ability of this to be transmitted by blood transfusion not documented, although viral RNA detected in serum. Exposure treatment with riboflavin and ultraviolet light (R + UV) reduces blood-borne pathogens while maintaining product quality. Here, we report on efficacy R UV reducing SARS-CoV-2 infectivity when tested human plasma...
Abstract The pandemic caused by SARS-CoV-2 has reached nearly every country in the world with extraordinary person-to-person transmission. most likely original source of virus was spillover from an animal reservoir and subsequent adaptation to humans sometime during winter 2019 Wuhan Province, China. Because its genetic similarity SARS-CoV-1, it is that this novel a similar host range receptor specificity. Due concern for human-pet transmission, we investigated susceptibility domestic cats...
Monkeypox virus has recently emerged from endemic foci in Africa and, since October 20, 2022, more than 73,000 human infections have been reported by the CDC over 100 countries that historically not monkeypox cases. The detection of skin lesions, blood, semen, and saliva infected patients with raises potential for disease transmission via routes previously documented, including blood plasma transfusions. Methods protecting supply against threats newly emerging agents exist include Pathogen...
The COVID-19 pandemic has generated intense interest in the rapid development and evaluation of vaccine candidates for this disease other emerging diseases. Several novel methods preparing are currently undergoing clinical response to urgent need prevent spread COVID-19. In many cases, these rely on new approaches production immune stimulation. We report use a method (SolaVAX) an inactivated candidate testing that hamster animal model its ability infection upon challenge with SARS-CoV-2...
Abstract The SARS-CoV-2 pandemic showed limitations in human outbreak testing. Veterinary diagnostic laboratories (VDLs) possess capabilities to bolster emergency test capacity. Surveys from 26 participating VDLs found testing was mutually beneficial, including One Health benefits. indicated >3.8 million samples during the pandemic, which included some challenges.
Rift Valley fever virus (RVFV) is a mosquito-borne, zoonotic that infects ruminants, including cattle, sheep, goats, camels, and buffalo. Multiplexing diagnostic assays can simultaneously detect antibodies against multiple RVFV antigens offer high-throughput test for disease surveillance vaccine evaluations. We describe the improvement evaluation of previously developed fluorescence microsphere immunoassay (FMIA) detection IgG IgM glycoprotein (Gn) immunogenic nucleocapsid protein (Np)....
Sporadic outbreaks of Rift Valley fever virus (RVFV), a zoonotic, mosquito-borne Phlebovirus, cause abortion storms and death in sheep cattle resulting catastrophic economic impacts endemic regions Africa. More recently, with changes competent vector distribution, growing international trade, its potential use for bioterrorism, RVFV has become transboundary animal disease significant concern. New sensitive techniques that determine presence, while lessening the environmental contamination...
Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic pathogen that causes periodic outbreaks of abortion in ruminant species and hemorrhagic disease humans sub-Saharan Africa. These have significant impact on veterinary public health. Its introduction to the Arabian Peninsula 2003 raised concerns further spread this transboundary non-endemic areas. are supported by presence competent vectors many countries. There no licensed RVF vaccine available for only conditionally United States....
Three cats with suspected Fournier's gangrene had an acute onset of clinical signs and bloodwork changes consistent sepsis. All cases similar progression wounds that were managed without aggressive surgical debridement, which is the currently accepted treatment choice. survived have maintained excellent long-term quality life.Fournier's a potentially fatal disease, few reported in veterinary literature. This retrospective case series describes only known reports survival from cats, none...
Abstract The COVID-19 pandemic has generated intense interest in the rapid development and evaluation of vaccine candidates for this disease other emerging diseases. Several novel methods preparing are currently undergoing clinical response to urgent need prevent spread COVID-19. In many cases, these rely on new approaches production immune stimulation. We report use a method (SolaVAX™) an inactivated candidate testing that hamster animal model its ability infection upon challenge with...
Background: SARS-CoV-2 continues to impact human health globally, with airborne transmission being a significant mode of transmission. In addition tools like vaccination and testing, countermeasures that reduce viral spread in indoor settings are critical. This study aims assess the efficacy UV-C light, utilizing Violett sterilization device, as countermeasure against highly susceptible Golden Syrian hamster model. Methods: Two cohorts naïve hamsters were subjected from experimentally...
Anthrax is a disease of concern in many mammals, including humans. Management primarily consists prevention through vaccination and tracking clinical-level observations because environmental isolation laborious bacterial distribution across large geographic areas difficult to confirm. Feral swine (Sus scrofa) are an invasive species with extensive range the southern United States that rarely succumbs anthrax. We present evidence feral might serve as biosentinels based on comparative...
Introduction Understanding the immune status of an individual using neutralizing antibody testing is complicated by continued evolution SARS-CoV-2 virus. Previous work showed that assays developed against wildtype strain were insufficient predictors neutralization omicron variants, thus we omicron-specific flow cytometry-based test and performed experiments to assess how well it compared PRNT assay (gold standard) whether could predict activity more recent subvariants such as XBB.1.5....
Background: SARS-CoV-2 continues to impact human health globally, with airborne transmission being a significant mode for transmission. In addition tools like vaccination and testing, counter-measures that reduce viral spread in indoor settings are critical. This study aims assess the efficacy of UV-C light, utilizing Violett sterilization device, as countermeasure against highly susceptible Golden Syrian hamster model. Methods: Two cohorts naïve hamsters were subjected from...
Emerging infectious disease threats are becoming more frequent due to various social, political and geographical pressures including increased human-animal contact, global trade, transportation changing climate conditions. As a result, the threat that emerging agents can be spread by blood contact or transfusion of products also becomes increasingly problematic. Blood is essential in treating patients with anemia, loss, other medical However, these lifesaving components become vector for...
Background: SARS-CoV-2 continues to impact human health globally, with airborne transmission being a significant mode for transmission. In addition tools like vaccination and testing, counter-measures that reduce viral spread in indoor settings are critical. This study aims assess the efficacy of UV-C light, utilizing Violett sterilization device, as countermeasure against highly susceptible Golden Syrian hamster model. Methods: Two cohorts naïve hamsters were subjected from experimentally...