A5100321674- Genomics and Phylogenetic Studies
- Gut microbiota and health
- Probiotics and Fermented Foods
- Plant Pathogens and Fungal Diseases
- Bacteriophages and microbial interactions
- Microbial infections and disease research
- Alzheimer's disease research and treatments
- Reproductive tract infections research
- Genomics and Chromatin Dynamics
- Health, Environment, Cognitive Aging
- Cancer-related gene regulation
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Plant-Microbe Interactions and Immunity
- Liver Disease Diagnosis and Treatment
- Fluoride Effects and Removal
- Phytoestrogen effects and research
- RNA Research and Splicing
- Plant tissue culture and regeneration
- Nuclear Receptors and Signaling
- Chemokine receptors and signaling
- Clostridium difficile and Clostridium perfringens research
- Lipid metabolism and biosynthesis
- Dental Health and Care Utilization
- Salivary Gland Disorders and Functions
Beijing Technology and Business University
2025
Dalian University
2024
Mayo Clinic in Arizona
2023-2024
Zhejiang University
2019-2024
First People's Hospital of Chongqing
2024
Hunan University of Traditional Chinese Medicine
2024
Shanghai Ocean University
2023-2024
Jiangsu Yanjiang Chemical Resources Development Research Institute (China)
2024
Xuzhou Medical College
2024
Second People’s Hospital of Huai’an
2024
The gut microbiota plays an important role in human health and longevity, the of centenarians shows unique characteristics. Nowadays, most microbial research on longevity is usually limited to bioinformatics level, lacking validating information culturing functional microorganisms. Here, we combined metagenomic sequencing large-scale vitro culture reveal structure world's town-Jiaoling, China, people different ages. Functional strains were isolated screened vitro, possible relationship...
Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent diseases worldwide. Exercise a first‐line therapy and an important preventive measure for patients with NAFLD, but underlying mechanisms are not clear. C57BL/6 mice were fed high‐fat diet (HFD) subjected to 12 wk swimming exercise. protected against hepatic lipid accumulation alleviated hepatocyte damage in HFD mice. Tandem mass tag—based quantitative proteomic analyses ingenuity pathway analysis revealed that exercise...
Manganese (Mn) is a neurotoxin that has been etiologically linked to the development of neurodegenerative diseases in case overexposure. It widely accepted overexposure Mn leads manganism, which clinical symptoms similar Parkinson's disease (PD), and referred as parkinsonism. Astrocytes have reported scavenge degrade extracellular α-synuclein (α-Syn) brain. However, mechanisms Mn-induced neurotoxicity associated with PD remain unclear. Serpina3n highly expressed astrocytes implicated several...
FANCD2 protein, a key coordinator and effector of the interstrand crosslink repair pathway, is also required to prevent excessive nascent strand degradation at hydroxyurea-induced stalled forks. The RAD51 recombinase has been implicated in regulation resection replication mechanistic contributions these proteins fork protection are not well understood. Here, we used purified study how each protein regulates DNA We characterized three mechanisms FANCD2-mediated protection: (1) N-terminal...
Antarctic microbes are important agents for evolutionary adaptation and natural resource of bioactive compounds, harboring the particular metabolic pathways to biosynthesize products. However, not much is known on symbiotic microbiomes fish in zone. In present study, culture method whole-genome sequencing were performed. Natural product analyses carried out determine biosynthetic potential. We report isolation identification a bacterium Serratia myotis L7-1, that highly adaptive resides...
Purpose: Hemorrhoids (HEM) are the most common perianal disease, but current observational studies have yielded inconsistent results in investigating risk factors. Our further exploration of factors will help prevent disease. Patients and Methods: We conducted a two-sample bidirectional Mendelian randomization (MR) analysis using publicly available genome-wide association (GWAS) statistics from multiple consortia. The inverse-variance weighted (IVW) method was used for primary analysis....
Excess fluoride in aqueous solutions can significantly affect dental and bone health. This study used two methods to prepare hydroxyapatite remove ions from water. The experiments showed that the adsorption capacity removal rate of (Xq-HAP) prepared by novel method were higher than for (Yt-HAP) conventional method. maximum ion trapping Xq-HAP could reach 29.04 mg g
The bacterial communities and physicochemical characteristics of four types extremely distinctive traditionally fermented vegetables (pickled pepper (PP), pickled Brassica napobrassica (PBN), salted flowers wild chives (SFWC), cucumber (PC)) were identified compared from north China. Lactobacillus was the main genus in PP PBN samples, with Oceanobacillus only being observed PBN. predominant SFWC Weissella, while PC they Carnimonas Salinivibrio. At species level, Companilactobacillus...
// Jin Lu 1, * , Su-Li Wang Ying-Chun 1 Yi-Nan Wu Xi Yu 2 Wan-Zhou Zhao and Jin-Hua 3 Department of Gynecological Oncology Surgery, Jiangsu Cancer Hospital, Institute Research, Nanjing Medical University Affiliated 210036, China The Han & Zaenker Institute, OG Pharmaceuticals, Jinling University, These authors have contributed equally to this work Correspondence to: Wang, email: wangjinhua588@163.com Keywords: ovarian cancer, WAVE3, cell motility, MMPs Received: October 29, 2016 Accepted:...
Abstract MicroRNA‐543 (miR‐543) has been found to play a suppressive role in various human cancers many studies, whereas the specific functions of miR‐543 muscle development remain poorly understood. Here, we that expression was high skeletal and increased during differentiation C2C12 cells. Overexpression repressed cell proliferation promoted differentiation, while knockdown produced opposite results. During myogenesis, predicted verified Krüppel‐like factor 6 ( KLF6 ), suppressor multiple...
The process of soybean fermentation has been practiced for more than 3,000 years. Although Dajiang and Sufu are two popular fermented products consumed in North China, limited information is available regarding their microbial composition. Hence, the current study sought to investigate, compare, physicochemical indicators communities traditional Sufu. Results showed that titratable acidity (TA), salinity, as well lactic acid, malic acid contents were significantly higher samples compared...
The "Fetal Origins of Adult Disease (FOAD)" hypothesis holds that adverse factors during pregnancy can increase the risk chronic diseases in offspring. Here, we investigated effects prenatal hypoxia (PH) on brain structure and function adult offspring explored role N6-methyladenosine (m
Apple replant disease (ARD) has led to severe yield and quality reduction in the apple industry. Fusarium solani (F. solani) been identified as one of main microbial pathogens responsible for ARD. Auxin (indole-3-acetic acid, IAA), an endogenous hormone plants, is involved almost all plant growth development processes plays a role immunity against pathogens. Gretchen Hagen3 (GH3) early/primary auxin response genes. The aim this study was evaluate function MdGH3-2 MdGH3-12 defense F. by...
Through the detection of changes in serum CCL28 content Sjögren's syndrome (SS), we explored significance disease diagnosis and evaluation. Serum samples were collected from patients with SS, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE). levels measured using enzyme-linked immunosorbent assay compared to healthy controls (HC). We also detected IgA focus score labial salivary gland (LSG) correlation CCL28. In addition, SS divided into two groups based on clinical symptoms...
The extreme environment shapes fungi in deep-sea sediments with novel metabolic capabilities. ubiquity of habitats supports their significant roles these ecosystems. However, there is limited research on the activities and adaptive mechanisms filamentous In this study, we investigated biological activities, including antibacterial, antitumor nematicidal activity Purpureocillium lilacinum FDZ8Y1, isolated from Mariana Trench. A key feature P. FDZ8Y1 was its tolerance to high hydrostatic...
Abstract Background Chronic medical conditions increase dementia risk, and the mechanism may be captured computationally by measures of accelerated brain aging. We hypothesized that quantifying impact chronic on GM WM aging will aid in measuring differential each condition shed light mechanisms through which they risk. specifically focused microstructural changes with Neurite Orientation Dispersion Density Imaging (NODDI) based advanced diffusion MRI ‐ neurite density index (NDI), free water...