A5061121367- Congenital Diaphragmatic Hernia Studies
- Diet, Metabolism, and Disease
- Cardiac Arrest and Resuscitation
- Congenital Heart Disease Studies
- Child and Adolescent Health
- Simulation-Based Education in Healthcare
- Metabolism, Diabetes, and Cancer
- Neonatal Respiratory Health Research
- Pancreatic function and diabetes
- Neonatal and fetal brain pathology
- Renal and Vascular Pathologies
- Birth, Development, and Health
- Tracheal and airway disorders
- Cardiovascular Issues in Pregnancy
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Ultrasound in Clinical Applications
- Obesity, Physical Activity, Diet
- Food Security and Health in Diverse Populations
- Anesthesia and Neurotoxicity Research
- Pregnancy-related medical research
- Gestational Diabetes Research and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Mechanical Circulatory Support Devices
- Pregnancy and preeclampsia studies
- Innovations in Medical Education
Children's Healthcare of Atlanta
2021-2024
Emory University
2020-2024
Children's Hospital of Philadelphia
2014-2020
Boston Children's Hospital
2019
Harvard University
2019
University of Washington
2019
Seattle University
2019
Rutgers, The State University of New Jersey
2008
The placenta is metabolically active and supports the growth of fetus. We hypothesize that deficits in capacity to maintain bioenergetic metabolic stability during pregnancy may result spontaneous preterm birth (SPTB). To explore this hypothesis, we performed a nested cased control study metabolomic signatures placentas from women with SPTB (<36 weeks gestation) compared normal pregnancies (≥38 gestation). for effects gestational age on metabolism, also studied subset metabolites...
Fructose consumption has increased dramatically but little is known about mechanisms regulating the intestinal fructose transporter GLUT5 in vivo. In neonatal rats, can be induced only by luminal and after 14 days of age, unless gut primed with dexamethasone prior to perfusion. To elucidate underlying modulation development, we first identified receptor mediating its effects then determined whether those were genomic. The glucocorticoid (GR) antagonist RU486 dose-dependently prevented...
Introduction Infants born with critical congenital heart defects (CCHDs) have unique transitional pathophysiology that often requires special resuscitation and management considerations in the delivery room (DR). While much is known about neonatal of infants CCHDs, current guidelines such as programme (NRP) do not include algorithm modifications or education specific to CCHDs. The implementation CCHD further hampered by large number healthcare providers (HCPs) need be reached. Online...
Background: Brain MRI is an important tool in the diagnosis and management of neonates with possible brain injury. In our large quaternary care neonatal intensive unit (NICU), MRIs are performed for identification white matter lesions preterm infants, prognostication hypoxic ischemic encephalopathy, peri-operative evaluation patients meningomyeloceles hydrocephalus among other indications. Patients often sedated order to obtain high quality images, but sedation carries risks complications....
Fructose (F) consumption has increased dramatically and is linked to childhood obesity but mechanisms regulating neonatal F absorption are unknown. The intestinal transporter GLUT5 cannot be enhanced by luminal in rats < 14 d old unless the gut primed with dexamethasone (D). effect of D requires transcription mediated glucocorticoid receptor (GR). We tested hypothesis that 10 pups, D‐ F‐induced upregulation involves trafficking GR from cytoplasm nucleus. Intestines pups (+ D), were...
Background: Although the AAP Section on Neonatal-Perinatal Medicine has prioritized advocacy as a mission goal, neonatal-perinatal medicine (NPM) fellow trainees have limited opportunities for local due to their rigorous clinical and research requirements difficulty translating neonatology intensive care training goals into efforts. However, general pediatricians experts in caring neonates, are unique position lead outreach projects focused mothers …
•Cardiac interdependence in conjoined twins is a rare phenomenon.•Presence of congenital heart disease may be an important prognostic factor.•There high risk high-output failure and pulmonary hypertension the donor twin.•If reconstruction feasible, early separation improve chance survival.