A5100413896- Data Quality and Management
- Polyomavirus and related diseases
- Advanced Causal Inference Techniques
- Data-Driven Disease Surveillance
- Cardiac electrophysiology and arrhythmias
- Heart Failure Treatment and Management
- Emergency and Acute Care Studies
- Statistical Methods in Clinical Trials
- Statistical Methods and Inference
- Statistical Methods and Bayesian Inference
- Ion channel regulation and function
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular and exercise physiology
- Metal complexes synthesis and properties
- Cardiac, Anesthesia and Surgical Outcomes
- Dialysis and Renal Disease Management
- Data Mining Algorithms and Applications
- Parathyroid Disorders and Treatments
- Ultrasound in Clinical Applications
- Multiple Sclerosis Research Studies
- Acute Lymphoblastic Leukemia research
- COVID-19 and healthcare impacts
- Plant Virus Research Studies
- Pharmacovigilance and Adverse Drug Reactions
- Magnetism in coordination complexes
New York University
2018-2025
NYU Langone Health
2018-2025
Indiana University School of Medicine
2013-2024
Indiana University – Purdue University Indianapolis
2013-2024
Indiana University Indianapolis
2016-2024
Indiana University
2008-2024
Regenstrief Institute
2009-2024
Tianjin Medical University General Hospital
2016-2022
University School
2008-2021
Richard M. Fairbanks Foundation
2020
To provide real-world evidence on risks and outcomes of breakthrough COVID-19 infections in vaccinated patients with cancer using the largest national cohort cases controls.
We review the class of inverse probability weighting (IPW) approaches for analysis missing data under various patterns and mechanisms. The IPW methods rely on intuitive idea creating a pseudo-population weighted copies complete cases to remove selection bias introduced by data. However, different are required depending pattern mechanism. begin with uniform (i.e. scalar indicator indicating whether or not full is observed) motivate approach. then generalise more complex settings. Our goal...
Abstract Background Cisplatin is an effective agent against osteosarcoma. Ototoxicity from osteosarcoma treatment protocols has not been well defined. The aim of this study was to determine the incidence and risk factors for hearing loss in children treated Procedure Eligible patients had diagnosed at Dana‐Farber Cancer Institute/Children's Hospital Boston January 1, 1995 December 12, 2004, were 3–18 years age diagnosis, a normal audiogram prior start chemotherapy. Patients received...
Propensity score-based methods or multiple regressions of the outcome are often used for confounding adjustment in analysis observational studies. In either approach, a model is needed: A describing relationship between treatment assignment and covariates propensity method regressions. The 2 models usually unknown to investigators must be estimated. correct specification, therefore, essential validity final causal estimate. We describe this article doubly robust estimator which combines both...
The intravoxel incoherent motion (IVIM) model of diffusion weighted imaging (DWI) provides biomarkers for breast tumor characterization. It has been extensively applied both diagnostic and prognostic goals in cancer, with increasing evidence supporting its clinical relevance. However, variable performance exists literature owing to the heterogeneity datasets quantification methods. This work used retrospective anonymized MRI data (302 patients) from three sites employing different software...
Background Toll-like receptor (TLR) agonists and radiation therapy hold promise for cancer immunotherapy. We conducted a phase I/II trial combining topical imiquimod (IMQ, TLR-7 agonist) local radiotherapy (RT) in patients with metastatic breast accompanied by longitudinal transcriptional analysis of tumor biopsies. Methods The primary objective the ( NCT01421017 ) was to assess systemic responses immune-related response criteria (irRC) after an 8-week cycle IMQ concurrent RT (cohort 1). An...
In recent years, ransomware has emerged as a formidable data security threat, causing significant privacy breaches that inflict substantial financial, reputational, and operational damages on society. Many studies employ dynamic feature analysis for detection. However, these methods utilize neither the internal semantic information (semantic inherent in features), nor external semantics (the wealth of existing knowledge expert experience with regard to detection). Moreover, conventional rely...
Importance More than 80% of patients who present to the emergency department (ED) with acute heart failure (AHF) are hospitalized. With more 1 million annual hospitalizations for AHF in US, safe and effective alternatives needed. Care short-stay units (SSUs) may be efficient hospitalization, especially lower-risk patients, but randomized clinical trial data lacking. Objective To compare effectiveness SSU care vs hospitalization AHF. Design, Setting, Participants This multicenter randomly...
In Brief Objective: Hot flashes are a major quality-of-life issue for breast cancer survivors, interrupting sleep, reducing quality of life, and diminishing treatment adherence to adjuvant endocrine therapies. Serotonin-norepinephrine reuptake inhibitors (SNRIs) selective serotonin (SSRIs) used widely but only partially effective hot flashes. Alternative strategies needed. We hypothesized that augmentation SSRI/SNRI therapy with hypnotic agents would optimize flash by improving sleep life....
The authors developed a sensitivity analysis method to address the issue of uncontrolled confounding in observational studies. In this method, use 1-dimensional function propensity score, which they refer as (SF), quantify hidden bias due unmeasured confounders. score is defined conditional probability being treated given measured covariates. Then construct SF-corrected inverse-probability-weighted estimators draw inference on causal treatment effect. This approach allows analysts conduct...
Urocortin, a potent vasodilator, plays physiological or pathophysiological roles in the cardiovascular system. However, little is known about its action human vascular tissues. The present study was designed to investigate effect of urocortin on internal mammary artery (IMA) vitro and possible underlying mechanisms.Human IMA obtained from patients undergoing coronary bypass grafting. isolated rings were mounted organ baths changes isometric tension measured by using Grass force-displacement...
Identifying genetic variants that affect the level of cell cycle reentry and establishing degree progression in those could help guide development therapeutic interventions aimed at effecting cardiac regeneration. We observed C57Bl6/NCR (B6N) mice have a marked increase cardiomyocyte S-phase activity after permanent coronary artery ligation compared with infarcted DBA/2J (D2J) mice.
Abstract Evaluation of impact potential uncontrolled confounding is an important component for causal inference based on observational studies. In this article, we introduce a general framework sensitivity analysis that inverse probability weighting. We propose methodology allows both non‐parametric and parametric analyses, which are driven by two parameters govern the magnitude variation multiplicative errors propensity score their correlations with outcomes. also specific model offers...
ABSTRACT Purpose Bioequivalent medications are required by the Food and Drug Administration to have identical warnings on their labels. This requirement has both clinical legal importance, yet never been validated. We sought determine real‐world consistency of electronic labeling for bioequivalent drugs from different manufacturers. Methods Using natural language processing, we indexed adverse drug reactions (ADRs) found in Adverse Reactions Post‐Marketing sections 9105 structured product...
Abstract Endometrial regenerative cells (ERCs) have been recently evaluated as an attractive candidate source for emerging stem cell therapies in immunosuppression, but their role immunoregulation is not fully understood. The present study was designed to investigate effects, especially on B-cell responses heart transplantation. In this study, ERCs were noninvasively obtained from menstrual blood. Heart transplantation performed between C57BL/6 (H-2b) donor mice and BALB/c (H-2d) recipients....
Key Points Mild-to-moderate CKD is associated with impairment in cardiovascular functional capacity as assessed by oxygen uptake at peak exercise (VO 2 Peak). Cardiac output significantly reduced patients mild-to-moderate and impaired VO Peak. Assessment of Peak cardiopulmonary testing can detect decrements function during early stages kidney decline that may not be captured using resting left ventricular geometric indices alone. Background Traditional diagnostic tools assess cardiac...
We review ideas, approaches and progress in the field of record linkage. point out that latent class models used probabilistic matching have been well developed applied a different context diagnostic testing when true disease status is unknown. The methodology setting can be potentially translated Although there are many methods for linkage, comprehensive evaluation wide range real-world data with characteristics match absent due to lack sharing. However, recent availability generators...
Apamin-sensitive small-conductance Ca